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Investigating X-Chromosome Inactivation

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ISBN-10: 3843390061

ISBN-13: 9783843390064

Edition: N/A

Authors: Sonja Pritchett

List price: $67.00
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Females have two alleles for each gene on the X- chromosome, whereas males have only one. This inequality is balanced by X-chromosome inactivation (XCI). This process transcriptionally silences one X- chromosome in every female cell. The choice of which X-chromosome should be turned-o is considered to be random. Studies on mice have revealed that a locus on the X-chromosome, the X controlling element (Xce), signi cantly in uences the choice of which X- chromosome is inactivated. Renault et al. (2007) studied a family of which many of the females exhibit symptoms of the X-linked recessive disease, Haemophilia A. The XCI ratios of the women in this family were signi cantly di erent from what…    
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Book details

List price: $67.00
Publisher: Lap Lambert Academic Publishing GmbH & Company KG
Binding: Paperback
Pages: 96
Size: 6.00" wide x 9.00" long x 0.23" tall
Weight: 0.330
Language: English