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Development of Tolerance and Dependence in Barbiturate Use

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ISBN-10: 3838305582

ISBN-13: 9783838305585

Edition: N/A

Authors: Ali Osman Konuray

List price: $69.00
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A mathematical model is constructed to study the development of tolerance and dependence to phenobarbital in continuous use. Phenobarbital is a sedative drug targeting the brain. As a side effect, it enhances its own metabolism rate. Also in regular use, the brain adapts to its presence and is rendered less sensitive to the drug with time. This decrease in drug effectiveness urges the user to increase the dose. A feedback loop results as the increased dose affects metabolism and neuroadaptation dynamics. Because adaptive changes persist even after drug intake stops, upon abrupt discontinuation to the drug, the patient experiences unwanted rebound effects. Using the model, we monitor the…    
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Book details

List price: $69.00
Publisher: Lambert Academic Publishing
Binding: Paperback
Pages: 108
Size: 6.00" wide x 9.00" long x 0.26" tall
Weight: 0.374
Language: English