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Gas-Phase Dissociation of Oligonucleotides Studied by Electrospray Ionization Tandem Mass Spectrometry

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ISBN-10: 383810966X

ISBN-13: 9783838109664

Edition: N/A

Authors: Jan Tromp

List price: $54.00
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Description:

Oligonucleotides have great potential in diagnostic and therapeutic applications. Their high specificity offers promise for the development of new drugs for protein induced diseases. Several modifications were introduced in oligonucleotides to improve nuclease resistance, binding affinity and specificity. The various unnatural oligonucleotides are not compatible with the classical sequencing techniques. Therefore, new methods for fast and unambiguous sequence verification are needed. Mass spectrometry has the potential to achieve these requirements.However, mechanistic aspects of oligonucleotide dissociation have to be clarified first. In this work unmodified DNA, RNA and several ribose or…    
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Book details

List price: $54.00
Publisher: S�dwestdeutscher Verlag f�r Hochschulschriften AG & Company KG
Binding: Paperback
Pages: 88
Size: 6.00" wide x 9.00" long x 0.18" tall
Weight: 0.286