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Heterogeneity in Multistage Carcinogenesis A Mixture Modeling Approach

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ISBN-10: 3838105095

ISBN-13: 9783838105093

Edition: 2009

Authors: Sandro Gsteiger

List price: $118.00
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Carcinogenesis is commonly described as a multistage process. In a first step, a stem cell is transformed via a series of mutations into an intermediate cell having a growth advantage. Under favorable conditions, such a cell will give rise to a clone of initiated cells. At some point, further alterations may transform a cell out of this clone into a malignant tumor cell. A mechanistic model of this process is given by the widely used two-stage clonal expansion model. In this text, Sandro Gsteiger studies how to introduce population heterogeneity into this model. Mixture modeling, which allows to describe frailty in a biologically meaningful way, is used. First, the focus is on the…    
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Book details

List price: $118.00
Copyright year: 2009
Publisher: S�dwestdeutscher Verlag f�r Hochschulschriften AG & Company KG
Binding: Paperback
Pages: 168
Size: 6.00" wide x 9.00" long x 0.36" tall
Weight: 0.528