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Skeletal Development and Remodeling in Health, Disease, and Aging

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ISBN-10: 1573315834

ISBN-13: 9781573315838

Edition: 2006

Authors: Mone Zaidi

List price: $181.95
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Description:

Our understanding of how the skeleton is remodeled and repaired has been enormously expanded in the past decade. Using advanced molecular technologies including transgenesis, gene knockout, and gene array, we are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. These studies have not only helped us understand the basic biological properties of the skeleton and how it responds to hormonal, cytokine, and mechanical stimulation, but also, in some instances, clarified the source of pathophysiology. The eventual goal of such discoveries is to lay down a firm scientific foundation for the identification of novel cellular and molecular targets for future drug development. This volume presents the significant headway that scientists have made in this undertaking and the book is organized around four broad themes: skeletal development and repair, molecular endocrinology of bone, bone cell biology, and conservation of skeletal integrity. Also included are papers that focus on current and emerging therapies for osteoporosis. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership for more information about becoming a member.
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Book details

List price: $181.95
Copyright year: 2006
Publisher: John Wiley & Sons, Incorporated
Publication date: 6/23/2006
Binding: Paperback
Pages: 596
Size: 6.00" wide x 9.00" long x 1.00" tall
Weight: 2.090
Language: English

Skeletal Development
PTHrP and Skeletal Development
Regulating Bone Growth with BMPs
BMP and BMP Inhibitors in Bone
BMP Signaling and Skeletalogensis
Function of BMP and BMP Antagonist in Adult Bone
Dysregulation of the BMP4 Signaling Pathway in Fibrodysplasia Ossificans Progressiva
Hypoxia, HIF-1???? and VHL in Chondrogenesis
Cellular and Molecular Mechanisms of Synovial Joint and Articular Cartilage Formation
Multiple Roles of Hoxc8 in Skeletal Development
Skeletal Remodeling
Osteoclasts and Integrins
Regulation of Osteoclast Differentiation
Signaling in Osteoclast and their Precursors
Canonical Wnt Signaling in Osteoblasts is Required for Osteoclast Differentiation
Inhibition of ATF4 Transcriptional Activity by TIAT/????-Taxilin Modulates Bone Mass
Paget's Disease of Bone and Genetic Disorders of RANK/OPG/RANK/NF-????B signaling
The Regulation of Cathepsin K Gene Expression
Direct and Indirect Estrogen Actions on Osteoblasts and Osteoclasts
Molecular Mechanism of the Life and Death of the Osteoclast
Understanding Parathyroid Hormone Action
New Insights Into the Mechanisms Involved in The Pleiotropic Actions of 1,25dihydroxyvitamin D3
Mechanisms of Vitamin D Receptor Action
Role of Connexin 43 in Osteoblast Response to Physical Load
Interactive Effect of Interleukin-6 and Prostaglandin E2 on Osteoclastogenesis via the OPG/RANK-L/RANK System
Does TNF Have Anti-Osteoclastogenic Actions?
Eosinophil Chemotactic Factor-L (ECF-L) Enhances Osteoclast Formation by Increasing ICAM-1 Expression
Mechanisms Of Bone Loss
Bone Cell Precursors and the Pathophysiology of Bone Loss
Autosomal Dominant Pseudohypoparathyroidism Type 1b is Caused by Different Microdeletions Within or Upstream of the GNAS Locus
Estrogen Regulation of Immune Cells Bone Interactions
Autoimmunity and Bone
Non-Steroid Immune Modulators and Bone Disease
Pathogenesis of Osteopenia/Osteoporosis Induced by Highly Active Anti-Retroviral Therapy for AIDS
Pituitary Hormones and Bone Loss
Bone Destruction in Multiple Myeloma
Osteogenic Regulation of Vascular Calcification
The OPG/TRAIL Complex in an In Vitro Osteoclastogenesis Model Dervied From Human Multiple Myeloma Bone Disease
Restoration of Bone Mass in hpg Mouse by Preoptic Area Grafting
IL-7 Drives T Cell-Medicated Bone Loss Following Ovariectomy
Restoring Skeletal Strength
Stem Cells and Tissue Engineering: Past, Present and Future
Bisphosphonates: From Bench to Bedside
Novel Targets and Therapeutics for Bone Loss
Advanced Imaging Assessment of Bone Quality
Bone Strength: Current Concepts
Anti-Catabolic Therapeutic Target in Bone Disease
Mechanisms Involved in Skeleton Anabolic Therapies
Misconceptions About Calcimimetics
Osteoblastic Activation in the Hematopoetic Stem Cell Niche
Circulating Cells with O