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Neurochemical Aspects of Excitotoxicity

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ISBN-10: 144192504X

ISBN-13: 9781441925046

Edition: 2008

Authors: Akhlaq A. Farooqui, Wei-Yi Ong, Lloyd A. Horrocks

List price: $179.99
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About 40% of central nervous system synapses use glutamate as the neurotransmitter. Over-stimulation of glutamate receptors produces neuronal injury or death by excitotoxicity, which is closely associated with neurochemical and neuropathological changes involved in acute neural trauma (stroke, spinal cord trauma, and head injury) and neurodegenerative diseases such as Alzheimer disease, Parkinson disease , Huntington disease, amyotrophic lateral sclerosis (ALS), Creutzfeldt-Jakob disease, Guam-type amyotrophic lateral sclerosis/Parkinson dementia (ALS/PDC), and multiple sclerosis.In the past decade, our understanding of the biochemistry, molecular biology, and neuropathology of the…    
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Book details

List price: $179.99
Copyright year: 2008
Publisher: Springer New York
Publication date: 10/29/2010
Binding: Paperback
Pages: 290
Size: 6.10" wide x 9.25" long
Weight: 1.034
Language: English

Dr. Akhlaq A. Farooqui is a leader in the field of brain phospholipases A2, bioactive ether lipid metabolism, polyunsaturated fatty acid metabolism, glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, glutamate-induced neurotoxicity and neurological disorders. He has discovered the stimulation of plasmalogen-selective phospholipase A2 (PlsEtn-PLA2) in brains from patients with Alzheimer disease. Stimulation of PlsEtn-PLA2 produces plasmalogen deficiency and increases levels of eicosanoids that may be related to the loss of synapses, induction of neuroinflammation and oxidative stress in brains of patients with Alzheimer disease. Dr. Farooqui has published cutting…