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| Advances in Stable Isotope Methodology | |
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| History | |
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| Using Stable Isotopes to Study Trace Element Metabolism | |
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| Stable Isotope Dosage, Preparation, and Administration | |
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| Conducting Stable Isotope Tracer Studies | |
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| Advances in Radioisotope Methodology | |
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| Radioisotopes | |
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| Whole-Body Counting Techniques | |
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| Body Imaging Techniques | |
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| Indirect Measurements of Absorption or Metabolism | |
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| Concluding Remarks | |
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| Tracer to Tracee Ratio for Compartmental Modeling of Stable Isotope Data | |
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| Introduction | |
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| Single Pool Tracer Kinetics and Measurement | |
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| Tracer to Tracee Ratio from Mass Spectrometry Measurements | |
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| Multi Pool Tracer Kinetics and Measurement | |
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| The Multiple Tracer Case | |
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| A Test of the Endogenous Constant Steady State | |
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| Assumption | |
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| Software Tool: TTRM | |
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| Conclusions | |
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| Methods for Analysis of Trace Element Absorption | |
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| Introduction | |
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| Iron | |
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| Copper | |
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| Zinc | |
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| Selenium | |
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| Kinetic Studies of Whole Body Trace Element Metabolism | |
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| Introduction | |
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| General Considerations in Study Design | |
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| Compartmental Modeling | |
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| Specific Examples of Isotope Turnover Studies | |
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| Concluding Remarks | |
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| Stable Isotope Methods for the Investigation of Iron Metabolism in Man | |
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| Introduction | |
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| Erythrocyte Incorporation and Iron Absorption | |
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| Zinc | |
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| Zinc and Copper | |
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| Selenium | |
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| Chromium | |
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| Conclusions | |
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| Use of Isotopes in the Assessment Of Zinc Status | |
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| Introduction | |
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| Isotopic Techniques | |
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| Conclusions | |
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| Copper Status and Metabolism Studied With Isotopic Tracers | |
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| Introduction | |
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| Background | |
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| Copper Status | |
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| Isotopic Tracers | |
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| Conclusions | |
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| Use of Stable Isotopes of Selenium to Investigate Selenium Status | |
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| Introduction | |
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| Dietary Selenium and Its Metabolism | |
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| The Role of Selenium in the Body | |
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| Assessment of Selenium Status and Use of Stable Isotopes | |
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| Conclusions | |
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| Use of Isotopes for Studies With Manganese, Chromium and Molybdenum | |
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| Manganese | |
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| Chromium | |
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| Molybdenum | |
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| Summary | |
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| Trace Element Studies in Infants and Pregnant or Lactating Women | |
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| Introduction | |
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| Iron | |
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| Zinc | |
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| Zinc and Copper | |
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| Selenium | |
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| Chromium | |
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| Conclusions | |
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| Stable Isotope Studies in the Elderly | |
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| Introduction | |
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| Practicalities of Working with Elderly Subjects | |
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| Ethical Considerations | |
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| Examples of Stable Isotope Studies in the Elderly | |
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| Selenium Status of the Elderly | |
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| Conclusions | |
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| Applications of Trace Element Studies in Developing Countries: Practical and Technical Aspects | |
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| Introduction | |
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| Applications of Isotope Studies in Developing Countries | |
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| Practical Aspects of Implementing Isotope Studies in Developing Countries | |
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| Technical Aspects of Implementing Isotope Studies in Developing Countries | |
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| Conclusions | |