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Metabolic Syndrome and Cardiovascular Disease

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ISBN-10: 1405195754

ISBN-13: 9781405195751

Edition: 2nd 2012

Authors: T. Barry Levine, Arlene Bradley Levine

List price: $169.95
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Description:

This new edition aims to explore the molecular mechanisms underlying insulin resistance and the metabolic syndrome, and to demonstrate how metabolic disorders such as diabetes, obesity, hypertension, and disturbances in lipid/carbohydrate metabolism, can be directly linked to cardiovascular disease. Secondly, it explains how therapeutic lifestyle changes and pharmacologic interventions are effective at improving insulin resistance and therefore reduce the threat of cardiovascular problems, and has sections highlighting the clinical outcomes of the various treatments. Fully comprehensive in both the science and research behind the metabolic syndrome, and also the treatments methods and preventative strategies used by clinicians when dealing with patients, this book is perfect for cardiovascular and endocrinologists alike, at both the bench and the bedside level. The book will be ideal equally for both cardiovascular and endocrinology clinicians and researchers. Researchers will use it to educate themselves in the current mechanistic insights on the derivation of the metabolic syndrome, insulin resistance and its comorbidities. Clinicians will use it to improve their prevention of metabolic disorders in patients and in order to treat and manage the syndrome and its complications according to current clinical guidelines.
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Book details

List price: $169.95
Edition: 2nd
Copyright year: 2012
Publisher: John Wiley & Sons, Incorporated
Publication date: 10/1/2012
Binding: Hardcover
Pages: 512
Size: 8.75" wide x 11.00" long x 1.25" tall
Weight: 3.256
Language: English

Preface
List of Abbreviations
The Metabolic Syndrome: A Relevant Concept?
Mitochondria
Background
Cellular respiration
Modulation of mitochondrial metabolic activity
Factors that affect mitochondrial number and activity
Peroxisome proliferator-activated receptor gamma coactivator-1
Mitochondrial production of prooxidant species
Mitochondria and nitric oxide
Mitochondrial calcium homeostasis
The mitochondrial permeability transition
Apoptosis
Causes for mitochondrial dysfunction
Implications of mitochondrial dysfunction
Mitochondrial dysfunction and cardiovascular disease
Mitochondrial dysfunction and metabolic disease
Conclusion
Bibliography
Telomeres
Telomere structure
Telomere function
Telomere shortening
Telomere dysfunction
Physiologic age
Gender differences
Telomerase
Cell senescence and apoptosis
Telomeres in aging
Risk factors for cardiometabolic disease
Telomeres� senescence� and chronic disease
Cardiovascular disease
Insulin resistance and type 2 DM
Conclusion
Bibliography
The FoxO Transcription Factors and Sirtuins
Forkhead transcription factors
Functions of FoxO
Cardiovascular forkhead effects
Metabolic forkhead effects
Histone acetylation and deacetylation
Sirtuin deacetylases
Sirtuin regulation
Antiinflammatory� cardiovascular� and myocyte sirtuin effects
Sirtuin effects on metabolism
Sirtuins and cell longevity
Forkhead deregulation and insulin resistance
Paradoxical effect of nutrition versus stress on cell death suppression
Conclusion
Bibliography
Insulin and Insulin-Like Growth Factor
Anabolism and catabolism
Control of plasma glucose
Insulin
Insulin receptor location
Metabolic insulin signaling
Insulin-mediated glucose uptake
Nutrient storage and metabolism
Vascular and antiinflammatory effects
Mitogenic action
Insulin-like growth factor
Insulin and IGF impact on cell longevity
Amylin
Glucagon
Conclusion
Bibliography
Oxidative Stress
Free radicals
Oxidases
Sources for free radicals
Endogenous antioxidants
Physiologic functions of oxidative stress
Mechanisms of oxidative damage
Cellular stress-sensitive pathways
Cellular targets of oxidative stress
Oxidative stress-related diseases
Endothelial dysfunction with oxidative stress
Cardiovascular disease
Insulin resistance and type 2 DM
Conclusion
Bibliography
Mental Stress
Stress responses
Central stress pathways
Peripheral stress pathways
Fight-flight-fright responses to acute stress
Sequelae of sustained passive stress
Inflammatory effects of stress pathways
Vascular and lipoprotein effects of stress pathways
Stress impact on body weight
Metabolic effects of stress pathways
Depression and other mood disturbances
Conclusion
Bibliography
Sleep
Stages of sleep
Cardiovascular parameters during normal sleep
Function of sleep
Sleep duration
Circadian rhythm
Examples of circadian regulation
Neurohormonal modulation of wakefulness
Neurohormonal modulation of sleep
Sleep-arousal transitions
Sleep deficit
Pathophysiologic effects of sleep debt
Sleep debt and risk of cardiometabolic disorder
Sleep disorders
Conclusion
Bibliography
Inflammation
Immune responses
Selected participants in the inflammatory response
C-reactive protein
The renin-angiotensin-aldosterone system and inflammation
Inflammation and chronic diseases
Inflammation� endothelial and vascular dysfunction
Inflammation and atherosclerosis
Acute inflammation� carbohydrate metabolism� and dyslipidemia
Chronic inflammation and the metabolic syndrome
Causes for systemic inflammation
Conclusion
Bibliography
Adipose Tissue and Overweight
Energy storage
Diverse fat depots
Adipose tissue as immune organ
Adipose tissue as endocrine organ
Adipokines with beneficial cardiometabolic effect
Adipokines with detrimental cardiometabolic effect
Obesity comorbidities and cardiovascular disease
Obesity� insulin resistance� and diabetes
Conclusion
Bibliography
Weight Loss and Diet
Homeostatic responses to weight gain and weight loss
Adipose weight loss effects
Antiinflammatory� vasculoprotective� and metabolic effects of weight loss
Dietary intervention for weight loss
Calorie restriction
Surgical intervention
Diet
Exercise as adjunct to weight loss
Conclusion
Bibliography
Skeletal Muscle and Exercise
Myocyte structure and function
Metabolic adaptations in skeletal muscle
Energy sensors
Skeletal muscle in inflammation
Skeletal muscle in insulin resistance
Exercise effect on inflammation and oxidative stress
Exercise effect on metabolism in obesity
Exercise effect and cardiovascular health
Exercise and insulin resistance
Exercise and mortality
Exercise recommendation
Conclusion
Bibliography
Lipids� Atherogenic Dyslipidemia� and Therapy
Apolipoproteins
Lipoproteins
Apo A-containing lipoproteins
Apo B-containing lipoproteins
Apolipoproteins C� D� and E
The triglyceride lipase family
The normal metabolism of free fatty acids
Inflammation and hepatic insulin resistance
Atherogenic dyslipidemia in insulin resistance
Lipid-lowering therapy
The HMG CoA reductase inhibitors
Nicotinic acid
The fibric acid derivatives
Bile acid sequestrants
Ezetimibe
CETP inhibition
Conclusion
Bibliography
The Endothelium� Cardiovascular Disease� and Therapy
Endothelial function
Nitric oxide synthase and eNOS
Endothelial NO synthesis
Specific enhancers of NO synthesis
Functions of nitric oxide
Shear stress and vascular function
Mechanisms of endothelial dysfunction
Insulin� insulin resistance� and endothelial dysfunction
Implications of endothelial dysfunction
Assessment of endothelial function
Hypertension
Cardiomyopathy
Coronary and peripheral vascular disease
Pharmacologic antagonism of the� renin-angiotensin-aldosterone system and endothelin-1
Beta-adrenergic blockade
Phosphodiesterase-5 inhibitors
Conclusion
Bibliography
Insulin Resistance� Metabolic Syndrome� and Therapy
Diagnostic criteria for the metabolic syndrome
Prevalence of the metabolic syndrome
Insulin resistance
Causes of insulin resistance
Pathways toward insulin resistance
Pharmacologic therapy to improve insulin sensitivity
Conclusion
Bibliography
Index