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Lectins

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ISBN-10: 1402066058

ISBN-13: 9781402066054

Edition: 2nd 2007 (Revised)

Authors: Nathan Sharon, Halina Lis

List price: $149.99
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Description:

Since publication of the first edition in 1989, great strides have been made in several areas of lectin research. Numerous lectins have been isolated from a variety of sources, and their functions in infection, inflammation and immunity, both innate and acquired, have been clarified. In addition, the three-dimensional structures of close to 200 lectins, and of many of their complexes with carbohydrates have been elucidated, providing an insight into the molecular basis of their specificity. As a result, this book is about 470 pages long (three times the size of the first edition), with over 200 figures and some 30 tables. The book starts with an overview of lectin research followed by a…    
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Book details

List price: $149.99
Edition: 2nd
Copyright year: 2007
Publisher: Springer
Publication date: 10/1/2007
Binding: Paperback
Pages: 454
Size: 6.25" wide x 9.25" long x 1.00" tall
Weight: 1.782
Language: English

Preface
Abbreviations
Introduction
History
The Early Pioneers
Blood Group Specificity
Mitogenic Stimulation
A Tool for Cancer Research
Lectins Galore
From Primary to Three-Dimensional Structures
Tools for Biological and Medical Research
Insight into Biological Functions
Into Contemporary Lectin Research
Detection, Occurence and Isolation
Detection
Occurrence
Higher plants
Lower plants
Fungi (including mushrooms and yeasts)
Animals
Micrororganisms
Isolation and Purification
From natural sources
By recombinant techniques
Specificity and Affinity
Methodology
Carbohydrate Specificity
Monosaccharides
Sialic acids
Oligosaccharides
Promiscuous lectins
Lectins with dual specificities
Role of Oligosaccharide Conformation
Effect of Multivalency
Energetics of Protein-Carbohydrate Interactions
Non-Carbohydrate Ligands
Leczymes
Molecular Structure
Plant Lectins
Legumes
Cereals
Amaryllidaceae and related monocots
Moraceae and related plants
Amaranthaceae
Euphorbiaceae and Loranthaceae
Solanaceae
Labiatae
Urticaceae
Animal Lectins
Galectins
C-type lectins
P-type lectins
Pentraxins
Siglecs
Calnexin, calreticulin and calmegin
ERGIC-53/MR60/p58
Ficolins and intelectins
Other animal lectins
Protozoan Lectins
Bacterial Lectins
Soluble lectins
Surface lectins
Type 1 fimbriae
P fimbriae
Type IV pili (fimbriae)
Other fimbriae
Viral Hemagglutinins
Influenza virus hemagglutinin
Murine polyoma virus
Foot-and-mouth disease virus
Rhesus rotavirus
Combining Sites
Lectin-Carbohydrate Bonds
Plant Lectins
Legume lectins
Binding sites for hydrophobic ligands
Cereal lectins
Amaryllidaceae and related monocots
Moraceae and related plants
Amaranthaceae
Euphorbiaceae
Urticaceae
Animal Lectins
Galectins
C-type lectins
P-type lectins
Siglecs
Calnexin
ERGIC-53/MR60/p58
Other animal lectins
Bacterial Lectins
Soluble lectins
Surface lectins
Other bacteria
Viral Hemagglutinins
Influenza virus
Murine polyoma virus
Foot-and-mouth disease virus
Rhesus rotavirus
Genetics, Molecular Biology and Evolution
Genetics and Molecular Biology
Plant lectins
Animal lectins
Bacterial lectins
Viral lectins
Evolution of Carbohydrate Binding Activity
Applications
Methodology
Glycoconjugates in Solution
Glycoproteins and polysaccharides
Glycolipids
Other carbohydrate derivatives
Cell-Bound Carbohydrates
Animal cells
Microorganisms
Mapping Neuronal Pathways
Cell Separation
Mitogenic Stimulation
General features
Mechanism of stimulation
Antiadhesion Therapy
Clinical Uses
Blood typing
Evaluation of immunocompetence
Karyotyping
Bone marrow transplantation
Enzyme replacement therapy
Diagnosis and Targeting
Other Applications
Lectin Cytotoxicity and Lectin-Resistant Cells
Mechanism of Action
Lectin-Resistant Mutants
Loss-of-function mutants
Gain-of-function mutants
Functions of cell surface sugars
Glycosylation engineering
Nutritional Effects
Lectins in Edible Plants
Deleterious Effects in the Intestinal Tract
Systemic Effects
Functions
Theoretical Considerations
Plant Lectins
Mediators of plant symbiosis with nitrogen-fixing bacteria
Plant defense
Animal Lectins
Galectins
C-Type lectins
P-lectins
Siglecs
Calnexin, calreticulin and related lectins
Sperm lectins
CD44
Microbial Lectins
Fungi
Protozoa
Bacteria
Viruses
Monosaccharide Ligands of Lectins
Oligosaccharide Ligands of Lectins
References
Index