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| Preface | |
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| Abbreviations | |
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| Introduction | |
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| History | |
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| The Early Pioneers | |
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| Blood Group Specificity | |
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| Mitogenic Stimulation | |
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| A Tool for Cancer Research | |
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| Lectins Galore | |
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| From Primary to Three-Dimensional Structures | |
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| Tools for Biological and Medical Research | |
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| Insight into Biological Functions | |
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| Into Contemporary Lectin Research | |
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| Detection, Occurence and Isolation | |
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| Detection | |
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| Occurrence | |
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| Higher plants | |
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| Lower plants | |
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| Fungi (including mushrooms and yeasts) | |
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| Animals | |
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| Micrororganisms | |
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| Isolation and Purification | |
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| From natural sources | |
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| By recombinant techniques | |
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| Specificity and Affinity | |
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| Methodology | |
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| Carbohydrate Specificity | |
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| Monosaccharides | |
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| Sialic acids | |
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| Oligosaccharides | |
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| Promiscuous lectins | |
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| Lectins with dual specificities | |
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| Role of Oligosaccharide Conformation | |
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| Effect of Multivalency | |
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| Energetics of Protein-Carbohydrate Interactions | |
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| Non-Carbohydrate Ligands | |
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| Leczymes | |
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| Molecular Structure | |
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| Plant Lectins | |
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| Legumes | |
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| Cereals | |
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| Amaryllidaceae and related monocots | |
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| Moraceae and related plants | |
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| Amaranthaceae | |
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| Euphorbiaceae and Loranthaceae | |
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| Solanaceae | |
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| Labiatae | |
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| Urticaceae | |
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| Animal Lectins | |
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| Galectins | |
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| C-type lectins | |
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| P-type lectins | |
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| Pentraxins | |
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| Siglecs | |
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| Calnexin, calreticulin and calmegin | |
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| ERGIC-53/MR60/p58 | |
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| Ficolins and intelectins | |
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| Other animal lectins | |
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| Protozoan Lectins | |
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| Bacterial Lectins | |
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| Soluble lectins | |
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| Surface lectins | |
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| Type 1 fimbriae | |
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| P fimbriae | |
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| Type IV pili (fimbriae) | |
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| Other fimbriae | |
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| Viral Hemagglutinins | |
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| Influenza virus hemagglutinin | |
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| Murine polyoma virus | |
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| Foot-and-mouth disease virus | |
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| Rhesus rotavirus | |
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| Combining Sites | |
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| Lectin-Carbohydrate Bonds | |
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| Plant Lectins | |
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| Legume lectins | |
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| Binding sites for hydrophobic ligands | |
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| Cereal lectins | |
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| Amaryllidaceae and related monocots | |
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| Moraceae and related plants | |
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| Amaranthaceae | |
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| Euphorbiaceae | |
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| Urticaceae | |
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| Animal Lectins | |
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| Galectins | |
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| C-type lectins | |
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| P-type lectins | |
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| Siglecs | |
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| Calnexin | |
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| ERGIC-53/MR60/p58 | |
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| Other animal lectins | |
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| Bacterial Lectins | |
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| Soluble lectins | |
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| Surface lectins | |
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| Other bacteria | |
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| Viral Hemagglutinins | |
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| Influenza virus | |
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| Murine polyoma virus | |
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| Foot-and-mouth disease virus | |
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| Rhesus rotavirus | |
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| Genetics, Molecular Biology and Evolution | |
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| Genetics and Molecular Biology | |
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| Plant lectins | |
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| Animal lectins | |
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| Bacterial lectins | |
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| Viral lectins | |
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| Evolution of Carbohydrate Binding Activity | |
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| Applications | |
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| Methodology | |
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| Glycoconjugates in Solution | |
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| Glycoproteins and polysaccharides | |
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| Glycolipids | |
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| Other carbohydrate derivatives | |
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| Cell-Bound Carbohydrates | |
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| Animal cells | |
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| Microorganisms | |
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| Mapping Neuronal Pathways | |
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| Cell Separation | |
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| Mitogenic Stimulation | |
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| General features | |
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| Mechanism of stimulation | |
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| Antiadhesion Therapy | |
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| Clinical Uses | |
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| Blood typing | |
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| Evaluation of immunocompetence | |
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| Karyotyping | |
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| Bone marrow transplantation | |
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| Enzyme replacement therapy | |
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| Diagnosis and Targeting | |
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| Other Applications | |
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| Lectin Cytotoxicity and Lectin-Resistant Cells | |
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| Mechanism of Action | |
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| Lectin-Resistant Mutants | |
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| Loss-of-function mutants | |
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| Gain-of-function mutants | |
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| Functions of cell surface sugars | |
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| Glycosylation engineering | |
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| Nutritional Effects | |
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| Lectins in Edible Plants | |
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| Deleterious Effects in the Intestinal Tract | |
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| Systemic Effects | |
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| Functions | |
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| Theoretical Considerations | |
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| Plant Lectins | |
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| Mediators of plant symbiosis with nitrogen-fixing bacteria | |
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| Plant defense | |
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| Animal Lectins | |
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| Galectins | |
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| C-Type lectins | |
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| P-lectins | |
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| Siglecs | |
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| Calnexin, calreticulin and related lectins | |
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| Sperm lectins | |
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| CD44 | |
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| Microbial Lectins | |
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| Fungi | |
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| Protozoa | |
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| Bacteria | |
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| Viruses | |
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| Monosaccharide Ligands of Lectins | |
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| Oligosaccharide Ligands of Lectins | |
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| References | |
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| Index | |