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Immunoregulation in Inflammatory Bowel Diseases - Current Understanding and Innovation

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ISBN-10: 1402058888

ISBN-13: 9781402058882

Edition: 2007

Authors: A. Dignass, E. -F. Stange, J. V. Weinstock, D. Rachmilewitz

List price: $219.99
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Description:

Significant scientific progress has been made in recent years in the aetiopathogenesis of chronic inflammatory bowel diseases (IBD), that has changed or will change in the future the diagnostic and therapeutic approach in these diseases. The relevance of classical conventional IBD therapies has been critically re-evaluated under criteria of evidence-based medicine approaches. On the other hand, new therapeutic options have emerged. These include modern immunomodulators, biologics, probiotics, worm eggs and extracorporeal therapies. The clinical relevance of these new modalities is often difficult to assess for physicians who do not work frequently with IBD patients. This book, the…    
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Book details

List price: $219.99
Copyright year: 2007
Publisher: Springer Netherlands
Publication date: 2/28/2007
Binding: Hardcover
Pages: 216
Size: 6.10" wide x 9.25" long x 0.75" tall
Weight: 1.144
Language: English

List of principal contributors
List of chairpersons
Preface
Advances in the Pathogenesis of Inflammatory Bowel Disease
Innate immune responses in inflammatory bowel disease
The adaptive immune responses in inflammatory bowel disease
Relevance of bacteria in the pathogenesis of inflammatory bowel disease
Taking a toll on MD-2 in inflammatory bowel disease
Optimization in Therapy through Improved Disease Classification?
Classification of inflammatory bowel disease can only be based on the clinical phenotype
Use of serology and genetics to differentiate inflammatory bowel disease phenotypes
Do biomarkers help to optimize therapy in inflammatory bowel disease?
Role of pharmacogenetics in the management of inflammatory bowel diseases
Conventional Immunomodulator Therapy
State-of-the-art therapy in accordance with guidelines
Increased risk of morbidity associated with immunomodulatory treatment in patients with inflammatory bowel diseases
Can immunomodulatory therapy be improved by metabolite measurement and combination therapy?
Relevance of Biologics
Top-down therapy for inflammatory bowel disease
'Step-up' versus 'top-down' strategies in inflammatory bowel disease - what do we know in 2006?
Importance of mucosal healing in Crohn's disease and ulcerative colitis
State-of-the-Art Lecture: Distinct antibacterial-defensin deficiencies in small intestinal and colonic Crohn's disease
New Therapeutic Approaches (Part I)
Oligonucleotides - new therapeutic approaches
Probiotics in inflammatory bowel disease
Helminth ova therapy for inflammatory bowel disease
Retarded release phosphatidylcholine: a new therapeutic option for ulcerative colitis
Topical steroids - rectal application
New Therapeutic Approaches (Part II)
Apheresis
The evolving understanding and therapy of Crohn's disease: innate immunity and sargramostim (GM-CSF)
Immunosuppression with tacrolimus, everolimus and sirolimus
T-cell modulating antibodies in inflammatory bowel disease
Index