Chromatin and Disease
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The packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin play key roles in nuclear processes such as transcription, replication, repair and recombination. Research in the last two decades has unveiled the fact that many diseases involve an aberration of these processes at the chromatin level. Similarly, it is becoming clear that different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of histone and non-histone proteins, chromatin modifying enzymes and last but not the least, important DNA-templated phenomena are the potential drug targets for diseases such as different types of cancer, neurodegenrative diseases, AIDS etc. While, the earliest form of chemotherapy employed chromosomal DNA cleavage and modification, the study of epigenetic functions and therapy has recently emerged as a frontline research activity. At this juncture we felt the necessity to make an overview of the current research activities in the above areas. It is obvious that this collection starts with our current knowledge of chromatin structure. This Work is the first endeavor to present different aspects encompassing the above theme. This volume will give a state-of-theart knowledge to undergraduate students, as well as the research community.
List price: $279.99
Copyright year: 2007
Publication date: 3/5/2007
Size: 6.25" wide x 9.25" long x 1.00" tall
|Chromatin Structure, Dynamics and Disease|
|Structural Organization of Dynamic Chromatin|
|ATP-Dependent Chromatin Remodelling: Action and Reaction|
|Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly (ADP-Ribose) Polymerase-1: Possible targets for drug-based therapies|
|Histone Variant Nucleosomes: Structure, function and implication in disease|
|Histone Variants and Complexes Involved in Their Exchange|
|Histone Chaperones in Chromatin Dynamics: Implications in disease manifestation|
|Functions of the Histone Chaperone Nucleolin in Diseases|
|Chromatin as a Target for the DNA-Binding Anticancer Drugs|
|Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease|
|Reversible Acetylation of Non Histone Proteins: Role in cellular function and disease|
|MARs and MARBPs: Key modulators of gene regulation and disease manifestation|
|Epigenetic Modifications of Chromatin: Implication in Disease and Therapeutics|
|Aberrant Forms of Histone Acetyltransferases in Human Disease|
|Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases: HDAC inhibitors as therapeutic tools|
|Functions of MYST Family Histone Acetyltransferases and Their Link to Disease|
|Role of Histone Phosphorylation in Chromatin Dynamics and Its Implications for Diseases|
|Regulation and Function of H3K9 Methylation|
|Histone Acetylation and Methylation: Combinatorial players for transcriptional regulation|
|Chromatin-Associated Regulation of HIV-1 Transcription: Implications for the development of therapeutic strategies|
|Small Molecule Modulators in Epigenetics: Implications in gene expression and therapeutics|