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Chromatin and Disease

ISBN-10: 1402054653

ISBN-13: 9781402054655

Edition: 2007

Authors: Tapas K. Kundu, Dipak Dasgupta

List price: $279.99
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Description:

The packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin play key roles in nuclear processes such as transcription, replication, repair and recombination. Research in the last two decades has unveiled the fact that many diseases involve an aberration of these processes at the chromatin level. Similarly, it is becoming clear that different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of histone and non-histone proteins, chromatin modifying enzymes and last but not the least, important DNA-templated phenomena are the potential drug targets for diseases such as different types of cancer, neurodegenrative diseases, AIDS etc. While, the earliest form of chemotherapy employed chromosomal DNA cleavage and modification, the study of epigenetic functions and therapy has recently emerged as a frontline research activity. At this juncture we felt the necessity to make an overview of the current research activities in the above areas. It is obvious that this collection starts with our current knowledge of chromatin structure. This Work is the first endeavor to present different aspects encompassing the above theme. This volume will give a state-of-theart knowledge to undergraduate students, as well as the research community.
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Book details

List price: $279.99
Copyright year: 2007
Publisher: Springer
Publication date: 3/5/2007
Binding: Hardcover
Pages: 458
Size: 6.25" wide x 9.25" long x 1.00" tall
Weight: 2.046

Preface
Chromatin Structure, Dynamics and Disease
Structural Organization of Dynamic Chromatin
ATP-Dependent Chromatin Remodelling: Action and Reaction
Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly (ADP-Ribose) Polymerase-1: Possible targets for drug-based therapies
Histone Variant Nucleosomes: Structure, function and implication in disease
Histone Variants and Complexes Involved in Their Exchange
Histone Chaperones in Chromatin Dynamics: Implications in disease manifestation
Functions of the Histone Chaperone Nucleolin in Diseases
Chromatin as a Target for the DNA-Binding Anticancer Drugs
Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease
Reversible Acetylation of Non Histone Proteins: Role in cellular function and disease
MARs and MARBPs: Key modulators of gene regulation and disease manifestation
Epigenetic Modifications of Chromatin: Implication in Disease and Therapeutics
Aberrant Forms of Histone Acetyltransferases in Human Disease
Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases: HDAC inhibitors as therapeutic tools
Functions of MYST Family Histone Acetyltransferases and Their Link to Disease
Role of Histone Phosphorylation in Chromatin Dynamics and Its Implications for Diseases
Regulation and Function of H3K9 Methylation
Histone Acetylation and Methylation: Combinatorial players for transcriptional regulation
Chromatin-Associated Regulation of HIV-1 Transcription: Implications for the development of therapeutic strategies
Small Molecule Modulators in Epigenetics: Implications in gene expression and therapeutics
Index
Colour Plates