Chromatin and Disease

Name: Chromatin and Disease
Availability: InStock
ISBN: 9781402054655

ISBN-10: 1402054653

ISBN-13: 9781402054655

Edition: 2007

Authors: Tapas K. Kundu, Dipak Dasgupta

List price: $219.99

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Description:

The packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin play key roles in nuclear processes such as transcription, replication, repair and recombination. Research in the last two decades has unveiled the fact that many diseases involve an aberration of these processes at the chromatin level. Similarly, it is becoming clear that different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of histone and non-histone proteins, chromatin modifying enzymes and last but not the least, important DNA-templated phenomena are the potential drug targets for diseases such as different…

Book details

List price: $219.99
Copyright year: 2007
Publisher: Springer Netherlands
Publication date: 3/5/2007
Binding: Hardcover
Pages: 458
Size: 6.10" wide x 9.25" long x 1.00" tall
Weight: 2.112
Language: English



Preface



Chromatin Structure, Dynamics and Disease



Structural Organization of Dynamic Chromatin




ATP-Dependent Chromatin Remodelling: Action and Reaction




Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly (ADP-Ribose) Polymerase-1: Possible targets for drug-based therapies




Histone Variant Nucleosomes: Structure, function and implication in disease




Histone Variants and Complexes Involved in Their Exchange




Histone Chaperones in Chromatin Dynamics: Implications in disease manifestation




Functions of the Histone Chaperone Nucleolin in Diseases




Chromatin as a Target for the DNA-Binding Anticancer Drugs




Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease



Reversible Acetylation of Non Histone Proteins: Role in cellular function and disease




MARs and MARBPs: Key modulators of gene regulation and disease manifestation




Epigenetic Modifications of Chromatin: Implication in Disease and Therapeutics



Aberrant Forms of Histone Acetyltransferases in Human Disease




Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases: HDAC inhibitors as therapeutic tools




Functions of MYST Family Histone Acetyltransferases and Their Link to Disease




Role of Histone Phosphorylation in Chromatin Dynamics and Its Implications for Diseases




Regulation and Function of H3K9 Methylation




Histone Acetylation and Methylation: Combinatorial players for transcriptional regulation




Chromatin-Associated Regulation of HIV-1 Transcription: Implications for the development of therapeutic strategies




Small Molecule Modulators in Epigenetics: Implications in gene expression and therapeutics



Index


Colour Plates