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Chromatin and Disease

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ISBN-10: 1402054653

ISBN-13: 9781402054655

Edition: 2007

Authors: Tapas K. Kundu, Dipak Dasgupta

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The packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin play key roles in nuclear processes such as transcription, replication, repair and recombination. Research in the last two decades has unveiled the fact that many diseases involve an aberration of these processes at the chromatin level. Similarly, it is becoming clear that different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of histone and non-histone proteins, chromatin modifying enzymes and last but not the least, important DNA-templated phenomena are the potential drug targets for diseases such as different…    
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Book details

Copyright year: 2007
Publisher: Springer
Publication date: 3/5/2007
Binding: Hardcover
Pages: 458
Size: 6.25" wide x 9.25" long x 1.00" tall
Weight: 2.046
Language: English

Chromatin Structure, Dynamics and Disease
Structural Organization of Dynamic Chromatin
ATP-Dependent Chromatin Remodelling: Action and Reaction
Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly (ADP-Ribose) Polymerase-1: Possible targets for drug-based therapies
Histone Variant Nucleosomes: Structure, function and implication in disease
Histone Variants and Complexes Involved in Their Exchange
Histone Chaperones in Chromatin Dynamics: Implications in disease manifestation
Functions of the Histone Chaperone Nucleolin in Diseases
Chromatin as a Target for the DNA-Binding Anticancer Drugs
Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease
Reversible Acetylation of Non Histone Proteins: Role in cellular function and disease
MARs and MARBPs: Key modulators of gene regulation and disease manifestation
Epigenetic Modifications of Chromatin: Implication in Disease and Therapeutics
Aberrant Forms of Histone Acetyltransferases in Human Disease
Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases: HDAC inhibitors as therapeutic tools
Functions of MYST Family Histone Acetyltransferases and Their Link to Disease
Role of Histone Phosphorylation in Chromatin Dynamics and Its Implications for Diseases
Regulation and Function of H3K9 Methylation
Histone Acetylation and Methylation: Combinatorial players for transcriptional regulation
Chromatin-Associated Regulation of HIV-1 Transcription: Implications for the development of therapeutic strategies
Small Molecule Modulators in Epigenetics: Implications in gene expression and therapeutics
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