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Brain Disorders in Critical Illness Mechanisms, Diagnosis, and Treatment

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ISBN-10: 1107029198

ISBN-13: 9781107029194

Edition: 2013

Authors: Robert D. Stevens, Tarek Sharshar, E. Wesley Ely

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Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This concise clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and…    
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Book details

Copyright year: 2013
Publisher: Cambridge University Press
Publication date: 9/19/2013
Binding: Hardcover
Pages: 456
Size: 7.60" wide x 9.92" long x 0.98" tall
Weight: 2.640
Language: English

Tarek Sharshar is Professor, Department of Intensive Care Medicine, Raymond Poincar� Hospital, University Versailles Saint-Quentin en Yvelines, Garches, France.

List of contributors
Epidemiology and Outcomes
The epidemiology of critical illness brain dysfunction
Cognitive dysfunction following critical illness
Psychiatric disorders following critical illnesses
Functional status and quality of life after critical illness
Delirium and dementia: unraveling the complex relationship
Behavioral Neurology in the ICU
Cognitive reserve
Neurology of consciousness impairments
Mechanisms of attention and attentional impairment
Neurology of sleep and sleep disorders
Neural basis of fear and anxiety
Biological Mechanisms
Experimental models of cognitive dysfunction in infection and critical illness
Neurobiological effects of systemic physiological and metabolic insults
Cerebral ischemia and reperfusion
Brain perfusion and autoregulation in systemic critical illness
Delirium and neurotransmitter dysfunction
Neuromodulatory and neurotoxic effects of sedative agents
Neuroimmunological cross-talk in critical illness
Inflammatory mechanisms in chronic neurodegenerative disease: the impact of microglia priming
The neuroendocrine response to critical illness
Autonomic dysfunction in SIRS and sepsis
Sepsis-induced neuronal dysfunction and death
Neuroimmunomodulation in sepsis
Diagnosis of Brain Dysfunction
Clinical neurological assessment of the critically ill patient
Bedside assessment of delirium in critically ill patients
Electroencephalography and evoked potentials in critically ill patients
Neuroimaging of delirium
Preventative and Therapeutic Interventions
Environmental modification
New paradigms in sedation of the critically ill patient
Pharmacological management of delirium
Pharmacogenomics and cerebral dysfunction
Early physical and occupational therapy
Rehabilitation after critical illness
Clinical Encephalopathy Syndromes
Drug-induced encephalopathy
Metabolic encephalopathies: inborn errors of metabolism causing encephalopathies in adults
Encephalopathy associated with alcohol or drug withdrawal
Posterior reversible encephalopathy syndrome (PRES): the essential elements
Hypoxic-ischemic encephalopathy
Sepsis-associated encephalopathy
Seizures and status epilepticus in critical illness
Encephalopathy and coma in acute and chronic liver failure
Neurological complications of cardiac surgery: stroke, encephalopathy, and cognitive decline
Color plate section is between pp. 320 and 321.