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Cancer Clinical Trials A Commonsense Guide to Experimental Cancer Therapies and Clinical Trials

ISBN-10: 098232197X

ISBN-13: 9780982321973

Edition: N/A

Authors: Tomasz M. Beer, Larry W. Axmaker

List price: $16.95
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Book details

List price: $16.95
Publisher: Diamedica
Publication date: 5/22/2012
Binding: Paperback
Pages: 192
Size: 6.00" wide x 9.00" long x 0.75" tall
Weight: 0.660
Language: English

Preface
Introduction
Cancer and Cancer Treatment Basics
What Is Cancer and How Is It Treated?
What Is Cancer?
The Six Hallmarks of Cancer
The Three Mainstays of Cancer Treatment
Surgery
Radiation Therapy
Medical Therapy (Medications)
Evolution of Medicine: From Systematic Knowledge to Evidence-Based Medicine and Toward Personalized Medicine
The Bottom Line
What Are Clinical Trials and How Are They Organized?
What Is a Clinical Trial?
A Brief History of Clinical Trials
Dr. Lind's Plan
Modern Medicine
The Key Ingredients of a Clinical Trial
Clinical Trials Versus Standard Care
The Eligibility Checklist Process
Informed Consent
Information About You
Statistics in Clinical Trials
What Is Risk Reduction?
What Is a Survival Benefit?
What Does "Significant" Mean?
The Bottom Line
The Types of Clinical Trials: Four Phases and More
Phase I: Safety Testing
Blood Level Studies
Variations of Phase I Testing
The Biologically Effective Dose
Why Would You Want to Participate in a Phase I Study?
Phase II: Initial Efficacy Testing: Does the New Drug Work?
Types of Phase II Studies
What's in a Phase II Study for You?
Phase III Trials: The New Treatment Compared to Standard Care
Why Would You Volunteer for a Phase III Clinical Trial?
Phase IV Studies
What's in a Phase TV Study for You?
Phase 0 (Zero) Studies
A Word About Other Types of Studies
Why Would You Consider Participating in a Clinical Trial That Doesn't Involve a Treatment Intended to Directly Treat Cancer?
The Bottom Line: The Advantages and Disadvantages of Various Types of Clinical Trials
Randomized Trials and Placebos
Randomization: Letting the Computer Decide
Randomization in Today's Clinical Trials
Comparing Active Treatment to No Treatment
Blinding and Placebos
Benefits Can Be Hard to See Without Blinding
The Appropriate Role of Placebos in Clinical Trials
The Placebo Effect
Placebos in History
Why Are Randomized Trials So Large?
What Happens If a Study Shows a Benefit Even Before It Is Finished?
Did I Get the Best Treatment?
How Can I Be Sure I Get the New Treatment?
The Bottom Line
Clinical Trials That Have Changed Cancer Care
Surgery Cures More Women with Breast Cancer When Supported by Chemotherapy
When Less May Be More
Does Surgery Really Help Men with Prostate Cancer?
A Sum That Is Truly Better Than Its Parts: Combining Chemotherapy Drugs
Location, Location, Location
A Successful Revolution: Targeting Mutations That Cause Cancer
Hormones and Cancer Prevention
Boost Your Immune System
Debunking a Medical Bias
When Our Basic Beliefs Are Challenged
The Next Breakthrough Study-What Will it Be?
The Bottom Line
Deciding Whether to Participate in a Clinical Trial
Is There a Clinical Trial That's Right for Me?
Deciding Whether to Participate in a Clinical Trial
What Should You Know Before Choosing a Clinical Trial?
What Potential Benefits and Risks Should You Consider Before Choosing a Clinical Trial?
The Effects of Attitudes, Emotions, and Reality in Choosing a Clinical Trial
"I Just Want to Be Left Alone!"
Cancer Support Groups
Choosing the Right Trial for Your Needs
I'm Interested. What Do I Do Next?
Start Close to Home
Know Your Disease State, Stage, and Prior and Current Treatments
Searching Online-The Basics
Advanced Searches
I've Done My Homework…Now What?
The Bottom Line
Who Is Looking Out for You and What Can You Expect?
How Are Studies Overseen and Regulated?
The Power of the FDA
Not One, but Two Animal Tests!
Truly Independent, Ail-Powerful Oversight: The Data Safely Monitoring Board
What Can I Expect From My Doctor and Investigative Team?
What If I Have Concerns and I'm Not Sure Where to Go for an Answer?
Am I Free to Quit If I Want To?
What If I Have Side Effects? How Will I Know If I Should Be Concerned?
What If Something Goes Wrong?
How Do You Get Through the Red Tape?
Why Are There Delays?
A Concern You May Have: "If I Start a Clinical Trial, and the Trial Medications Don't Work, I Could Be Wasting Valuable Time."
The Bottom Line
Who Pays for Clinical Trials-And What Can They Cost?
What Costs Are Involved in Clinical Trials?
Who Pays for These Costs?
Costs of Your Care and Insurance Coverage of Cancer Clinical Trials
Medicare Comes Through
Traditional Health Insurance
The Bottom Line
Medical Treatment of Cancer Now, and in the Future
Cancer Drugs Currently in Use and Being Tested in Trials
Chemotherapy Drugs
Antimetabolites
Alkylating Agents
DNA Cross-Linking Platinum Derivatives
Antitumor Antibiotics
Topoisomerase Inhibitors
Microtubule Assembly and Disassembly Inhibitors (Mitotic Inhibitors)
Hormonal Agents
Testosterone- and Estrogen-Lowering Drugs
Hormone-Blocking Drugs
Testosterone Conversion/Activation Blockers
Small-Molecule Targeted Drugs
Monoclonal Antibodies
Immunotherapy
Differentiation Therapy
Gene Therapy
A Last Word About Drugs
The Bottom Line
The Future of Cancer Treatment and Clinical Trials: Personalized Medicine
Targeted Therapy
Personalized Therapy
Pharmacogenomics
The Bottom Line
A Final Word
Tell Us What You Think
Glossary
Resources
General Clinical Trials Information
Information Specific by Tumor Type
Index