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Biology of Cancer

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ISBN-10: 0815340788

ISBN-13: 9780815340782

Edition: 2007

Authors: Robert A. Weinberg

List price: $198.00
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The Biology of Canceris a comprehensive, authoritative, up-to-date textbook written by a major researcher in the field. It clearly presents the principles of cancer biology in an organized and accessible fashion. The information unfolds through the presentation of key experiments which give readers a sense of discovery, and provides insights into the conceptual foundation underlying cancer biology.
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Book details

List price: $198.00
Copyright year: 2007
Publisher: Taylor & Francis Group
Publication date: 6/9/2006
Binding: Hardcover
Pages: 864
Size: 8.50" wide x 10.75" long x 1.25" tall
Weight: 4.576
Language: English

The Biology and Genetics of Cells and Organisms
Mendel establishes the basic rules of genetics
Mendelian genetics helps to explain Darwinian evolution
Mendelian genetics governs how both genes and chromosomes behave
Chromosomes are altered in most types of cancer cells
Mutations causing cancer occur in both the germ-line and the soma
Genotype embodied in DNA sequences creates phenotype through proteins
Gene expression patterns also control phenotype
Transcription factors control gene expression
Metazoa are formed from components conserved over vast evolutionary time periods
Gene cloning techniques revolutionized the study of normal and malignant cells
The Nature of Cancer
Tumors are complex tissues
Tumors arise from many specialized cell types throughout the body
Some types of tumors do not fit into the major classifications
Cancers seem to develop progressively
Tumors are monoclonal growths
Cancers occur with vastly different frequencies in different human populations
The risks of cancers often seem to be increased by assignable influences including lifestyle
Specific chemical agents can induce cancer 2.9 Both physical and chemical carcinogens act as mutagens
Mutagens may be responsible for some human cancers
Synopsis and prospects Essential Concepts Additional Reading
Tumor viruses
Peyton Rous discovers a chicken sarcoma virus
Rous sarcoma virus is discovered to transform infected cells in culture
The continued presence of RSV is needed to maintain transformation
Viruses containing DNA molecules are also able to induce cancer
Tumor viruses induce multiple changes in cell phenotype including acquisition of tumorigenicity
Tumor virus genomes persist in virus-transformed cells by becoming part of host cell DNA
Retroviral genomes become integrated into the chromosomes of infected cells
A version of the src gene carried by RSV is also present in uninfected cells
RSV exploits a kidnapped cellular gene to transform cells
The vertebrate genome carries a large group of proto-oncogenes
Slowly transforming retroviruses activate proto-oncogenes by inserting their genomes adjacent to these cellular genes
Some retroviruses naturally carry oncogenes
Synopsis and prospects Essential Concepts Additional Reading
Cellular oncogenes
Can cancers be triggered by the activation of endogenous retroviruses?
Transfection of DNA provides a strategy for detecting nonviral oncogenes
Oncogenes discovered in human tumor cell lines are related to those carried by transforming retroviruses
Proto-oncogenes can be activated by genetic changes affecting either protein expression or structure
Variations on a theme: the myc oncogene can arise via at least three additional distinct mechanisms
A diverse array of structural changes in proteins can also lead to oncogene activation
Synopsis and prospects Essential Concepts Additional Reading
5 Growth factors and their receptors
Normal metazoan cells control each other's lives
The Src protein functions as a tyrosine kinase
The EGF receptor functions as a tyrosine kinase
An altered growth factor receptor can function as an oncoprotein
A growth factor gene can become an oncogene: the case of sis
Transphosphorylation underlies the operations of receptor tyrosine kinases
Yet other types of receptors enable mammalian cells to communicate with their environment
Integrin receptors sense association between the cell and the extracellular matrix
The Ras protein, an apparent component of the downstream signaling cascade, functions as