Physiological Control Systems Analysis, Simulation, and Estimation

ISBN-10: 0780334086

ISBN-13: 9780780334083

Edition: 2000

Authors: Michael C. K. Khoo, Michael C. Khoo

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Biomedical / Electrical Engineering Physiological Control Systems Analysis, Simulation, and Estimation A volume in the IEEE Press Series in Biomedical Engineering Metin Akay, Series Editor Many recently improved medical diagnostic techniques and therapeutic innovations have resulted from physiological systems modeling. This comprehensive book will help undergraduate and graduate students and biomedical scientists to gain a better understanding of how the principles of control theory, systems analysis, and model identification are used in physiological regulation. Ample Simulink and MATLAB examples throughout the text and posted at an IEEE FTP site will provide you with a hands-on approach for exploring modeling and analysis of biological control systems. You will learn about classical control theory and its application to physiological systems, and contemporary topics and methodologies shaping bioengineering research today. Discussions on the latest developments in system identification, optimal control, and nonlinear dynamical analysis will keep you up-to-date with recent bioengineering advances. From modeling and stability analysis to feedback control in physiological regulatory mechanisms, Physiological Control Systems provides an in-depth study of key bioengineering principles that is simply unmatched in the field.
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Book details

List price: $211.00
Copyright year: 2000
Publisher: John Wiley & Sons, Incorporated
Publication date: 10/8/1999
Binding: Hardcover
Pages: 344
Size: 7.25" wide x 10.25" long x 1.00" tall
Weight: 1.936
Language: English

About the Author Michael C. K. Khoo is professor of biomedical engineering at the University of Southern California, Los Angeles. His current research interests include respiratory and cardiac autonomic control during sleep, biomedical signal processing, and physiological modeling. Dr. Khoo was the recipient of a National Institutes of Health Research Career Development Award from 1990 to 1996 and the American Lung Association Career Investigator Award from 1991 to 1996. He has published widely in the field of cardiorespiratory and sleep research, and is the editor of two books: Bioengineering Approaches to Pulmonary Physiology and Medicine (Plenum, 1996) and Modeling and Parameter Estimation in Respiratory Control (Plenum, 1989), in addition to over 85 journal articles, book chapters, and conference papers.

Preliminary Considerations
Historical Background
Systems Analysis: Fundamental Concepts
Physiological Control Systems Analysis: A Simple Example
Differences between Engineering and Physiological Control Systems
The Science (and Art) of Modeling
Mathematical Modeling
Generalized System Properties
Models with Combinations of System Elements
Linear Models of Physiological Systems: Two Examples
Distributed-Parameter versus Lumped-Parameter Models
Linear Systems and the Superposition Principle
Laplace Transforms and Transfer Functions
The Impulse Response and Linear Convolution
State-Space Analysis
Computer Analysis and Simulation--MATLAB and SIMULINK
Static Analysis of Physiological Systems
Open-Loop versus Closed-Loop Systems
Determination of the Steady-State Operating Point
Steady-State Analysis Using SIMULINK
Regulation of Cardiac Output
The Cardiac Output Curve
The Venous Return Curve
Closed-Loop Analysis: Heart and Systemic Circulation Combined
Regulation of Glucose
Chemical Regulation of Ventilation
The Gas Exchanger
The Respiratory Controller
Closed-Loop Analysis: Lungs and Controller Combined
Time-Domain Analysis of Linear Control Systems
Linearized Respiratory Mechanics: Open-Loop versus Closed-Loop
Open-Loop and Closed-Loop Transient Responses: First-Order Model
Impulse Response
Step Response
Open-Loop versus Closed-Loop Transient Responses: Second-Order Model
Impulse Responses
Step Responses
Descriptors of Impulse and Step Responses
Generalized Second-Order Dynamics
Transient Response Descriptors
Open-Loop versus Closed-Loop Dynamics: Other Considerations
Reduction of the Effects of External Disturbances
Reduction of the Effects of Parameter Variations
Integral Control
Derivative Feedback
Transient Response Analysis Using MATLAB
SIMULINK Application: Dynamics of Neuromuscular Reflex Motion
A Model of Neuromuscular Reflex Motion
SIMULINK Implementation
Frequency-Domain Analysis of Linear Control Systems
Steady-State Responses to Sinusoidal Inputs
Open-Loop Frequency Response
Closed-Loop Frequency Response
Relationship between Transient and Frequency Responses
Graphical Representations of Frequency Response
Bode Plot Representation
Nichols Charts
Nyquist Plots
Frequency-Domain Analysis Using MATLAB and SIMULINK
Frequency Response of a Model of Circulatory Control
The Model
Simulations with the Model
Frequency Response of the Model
Frequency Response of Glucose-Insulin Regulation
The Model
Simulations with the Model
Frequency Responses of the Model
Stability Analysis: Linear Approaches
Stability and Transient Response
Root Locus Plots
Routh-Hurwitz Stability Criterion
Nyquist Criterion for Stability
Relative Stability
Stability Analysis of the Pupillary Light Reflex
Routh-Hurwitz Analysis
Nyquist Analysis
Model of Cheyne-Stokes Breathing
CO[subscript 2] Exchange in the Lungs
Transport Delays
Controller Responses
Loop Transfer Functions
Nyquist Stability Analysis Using MATLAB
Identification of Physiological Control Systems
Basic Problems in Physiological System Analysis
Nonparametric and Parametric Identification Methods
Numerical Deconvolution
Least Squares Estimation
Estimation Using Correlation Functions
Estimation in the Frequency Domain
Optimization Techniques
Problems in Parameter Estimation: Identifiability and Input Design
Structural Identifiability
Sensitivity Analysis
Input Design
Identification of Closed-Loop Systems: "Opening the Loop"
The Starling Heart-Lung Preparation
Kao's Cross-Circulation Experiments
Artificial Brain Perfusion for Partitioning Central and Peripheral Chemoreflexes
The Voltage Clamp
Opening the Pupillary Reflex Loop
Read Rebreathing Technique
Identification Under Closed-Loop Conditions: Case Studies
Minimal Model of Blood Glucose Regulation
Closed-Loop Identification of the Respiratory Control System
Optimization in Physiological Control
Optimization in Systems with Negative Feedback
Single-Parameter Optimization: Control of Respiratory Frequency
Constrained Optimization: Airflow Pattern Regulation
Lagrange Multiplier Method
Optimal Control of Airflow Pattern
Constrained Optimization: Control of Aortic Flow Pulse
Calculus of Variations
Optimal Left Ventricular Ejection Pattern
Adaptive Control of Physiological Variables
General Considerations
Adaptive Buffering of Fluctuations in Arterial P[characters not reproducible]
Nonlinear Analysis of Physiological Control Systems
Nonlinear versus Linear Closed-Loop Systems
Phase-Plane Analysis
Local Stability: Singular Points
Method of Isoclines
Nonlinear Oscillators
Limit Cycles
The van der Pol Oscillator
Modeling Cardiac Dysrhythmias
The Describing Function Method
Application: Periodic Breathing with Apnea
Models of Neuronal Dynamics
The Hodgkin-Huxley Model
The Bonhoeffer-van der Pol Model
Complex Dynamics in Physiological Control Systems
Spontaneous Variability
Nonlinear Control Systems with Delayed Feedback
The Logistic Equation
Regulation of Neutrophil Density
Model of Cardiovascular Variability
Coupled Nonlinear Oscillators: Model of Circadian Rhythms
Time-Varying Physiological Closed-Loop Systems: Sleep Apnea Model
Propagation of System Noise in Feedback Loops
Commonly Used Laplace Transform Pairs
List of MATLAB and SIMULINK Programs/Functions
About the Author
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