Biology of Disease

ISBN-10: 0748772103

ISBN-13: 9780748772100

Edition: 2007

List price: $83.00 Buy it from $7.85
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Description:

Book Narrative Biology of Disease is a text for undergraduate biomedical students who are intending to pursue a career in the medical support services. Written in an engaging manner, it is also an ideal reference for medical and clinical technicians and will be useful for students needing a broad overview of the biological basis of disease. Specific areas covered include haematology, immunology, and microbiology, along with genetic, cardiovascular, and diet-related disorders. Cancer and diseases of ageing are also included. Extensively illustrated throughout, the text is further supported by bullet-point summaries and revision questions. Biology of Disease also contains examples and case studies of common diseases, discussing preventative measures and treatments. Key Sales Points: - Summarizes the biological basis of common diseases. This ensures the students understand the basics of the common diseases they are likely to come across in biomedical/ medtech. profession - Case studies and clinical applications put theory in a medical context allowing the reader to relate the theory to real life situations - Self-test questions at the end of each chapter ensure the student has grasped and understood the most important concepts
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Book details

List price: $83.00
Copyright year: 2007
Publisher: Taylor & Francis Group
Publication date: 12/13/2006
Binding: Paperback
Pages: 600
Size: 8.50" wide x 10.50" long x 1.25" tall
Weight: 1.870
Language: English

Chris Smith is Lecturer in Support for Learning and Inclusive Education at the University of Glasgow. She is a Project Leader with the Scottish Network for Able Pupils.

Preface
Glossary
The Nature and Investigation of Diseases
Introduction
Characteristic Features of Diseases
Etiology
Pathogenesis
Manifestations of Diseases
Outcome of a Disease
Classification of Diseases
Epidemiology of Disease
Investigating Diseases
Types of Pathology Laboratories
Role of Hospital Laboratory Tests
Hospital Laboratory Tests
Evaluation of Laboratory Tests
Reference Ranges
Quality of Test Results and Clinical Auditing
Summary
Further Reading
Pathogens and Virulence
Introduction
Types of Pathogens
Prions
Viruses
Bacteria
Protozoa, Fungi and Helminths
Arthropods and Vertebrates
Virulence Factors
Defensive Virulence Factors
Offensive Virulence Factors
Course of Infection
Summary
Further Reading
Infectious Diseases and Treatments
Introduction
Infections of the Skin
Infections of the Eyes, Ears and Central Nervous System
Infections of the Respiratory System
Infections of the Gastrointestinal Tract
Infections of the Urogenital System
Sepsis and Systemic Infections
Investigating Infectious Diseases
Culture
Serological Tests
Biochemical and Molecular Biological Techniques
Preventing Infectious Diseases
Controlling the Spread of Pathogens
Treatment of Infectious Diseases
Antiviral Drugs
Antibacterial Drugs
Antifungal, Antiprotozoal and Antihelminthic Drugs
Combination Therapy
Surgery
Summary
Further Reading
The Immune System
Introduction
Types of Immune Defense
Nonspecific Defenses
Interferons
Complement
Nonspecific Cells
Mononuclear Leukocytes
Inflammation and the Acute Phase Response
Specific Immune Responses
Roles of Humoral and Cell-Mediated Immunity
Humoral Immunity
Cell-Mediated Immunity
Small Lymphocytes
Production of a Specific Immune Response
Humoral Immunity
Summary
Further Reading
Disorders of the Immune System
Introduction
Immunodeficiency Diseases
Primary Immunodeficiency Disease
Autoimmune Disorders
Classification of Autoimmune Disorders
Autoimmune Disorders Affecting Endocrine Glands
Antiglomerular Basement Membrane Disease
Myasthenia Gravis
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Immunological Hypersensitivity
Hypersensitivity
Hypersensitivity
Hypersensitivity
Delayed Type Hypersensitivity
Summary
Further Reading
Transfusion and Transplantation
Introduction
Blood and Blood Products for Transfusion
The Discovery of the Blood Group Systems
The ABO Blood Group System (ISBT 001)
The Antigens of the ABO System
Antibodies of the ABO Blood Group System
Consequences of ABO Incompatible Transfusions
The Rh Blood Group System (ISBT 004)
Hemolytic Disease of the Newborn
Other Blood Group Systems
Laboratory Determination of Blood Groups
Role of Complement in Transfusion Reactions
Hazards of Transfusion
Transfusion Related Acute Lung Injury
Iron Overload
Alloimmunization
Graft versus Host Disease
Infections
Screening of Blood Donors
Transplantation of Solid Tissues and Organs
Immunological Rejection of Transplants
Causes of Graft Rejection
The HLA System
HLA Typing
Immunosuppression
Hemopoietic Stem Cell Transplantation
Bone Marrow Transplantation
Peripheral Blood Stem Cell Transplantation
Umbilical Cord Stem Cell Transplantation
Identification of Hemopoietic Stem Cells
Summary
Further Reading
Disorders of the Endocrine System
Introduction
Hormone Production
Mechanisms of Hormonal Action
Causes of Endocrine Disorders
The Pituitary Gland
Disorders of Pituitary Function
Growth Hormone Disorders
Diagnosis and Treatment of Growth Hormone Disorders
Thyroid Hormone Disorders
Diagnosis and Treatment of Thyroid Disorders
Regulation of Blood Glucose
Diabetes Mellitus
Hypoglycemia
Disorders of the Adrenal Cortex
Addison's Disease
Cushing's Syndrome
Congenital Adrenal Hyperplasia
Conn's Syndrome
Reproductive Hormones
Disorders of Sex Hormones
Summary
Further Reading
Disorders of Water, Electrolytes and Urate Balances
Introduction
Kidneys
Renal Function Tests
Renal Failure
Disorders of Water Homeostasis
Disorders of Na[superscript +] Homeostasis
Disorders of K[superscript +] Homeostasis
Disorders of Ca[superscript 2+] Homeostasis
Disorders of Phosphate Homeostasis
Disorders of Mg[superscript 2+] Homeostasis
Disorders of Urate Metabolism
Summary
Further Reading
Disorders of Acid-Base Balance
Introduction
The Production and Transport of Carbon Dioxide
Buffering and the Excretion of H[superscript +]
Types of Acid-Base Disorders
Metabolic Acid-Base Disorders
Respiratory Acid-Base Disorders
Mixed Acid-Base Disorders
Investigating Acid-Base Disorders
Summary
Further Reading
Diet and Disease
Introduction
Diet and Nutrition
Nutrients and Energy
Carbohydrates
Lipids
Proteins
Water
Vitamins
Minerals and Trace Elements
Nutritional Disorders
Protein-Energy Malnutrition
Obesity
Anorexia Nervosa and Bulimia Nervosa
Disorders of Vitamin Nutrition
Nutritional Disorders of Minerals and Trace Elements
Investigating Nutritional Disorders
Protein-Energy Malnutrition
Obesity
Anorexia Nervosa and Bulimia Nervosa
Vitamins
Minerals and Trace Elements
General Management of Nutritional Disorders
Summary
Further Reading
Disorders of the Gastrointestinal Tract, Pancreas, Liver and Gall Bladder
Introduction
The Gastrointestinal Tract and its Accessory Organs
Digestion
Mouth
Stomach
Small Intestine
Absorption of the Products of Digestion
Activities of the Large Intestine
The Small Intestine and Homeostasis
Hormonal Control of GIT Secretions
Disorders of the GIT and Accessory Organs
Disorders of the Exocrine Pancreas
Disorders of the Liver, Gall Bladder and Bile Duct
Disorders of the Stomach
Disorders of the Small Intestine
Disorders of the Large Intestine
Summary
Further Reading
Toxicology
Introduction
Drug Action, Metabolism, Distribution and Excretion
Physiological Detoxification Mechanisms
Symptomatic Poisoning
Common Poisons
Paracetamol
Aspirin
Ethanol
Methanol
Ethylene Glycol
Barbiturates
Carbon Monoxide
Paraquat
Metals
Summary
Further Reading
Disorders of the Blood
Introduction
Blood Cells and Platelets
Hemoglobins
Key Properties of Hemoglobin
Embryonic and Fetal Hemoglobins
Hemostasis and Blood Clotting
The Intrinsic Pathway
The Extrinsic Pathway
Common Final Pathway
Prevention of Clotting
Dissolution of Clots
Anemias
Microcytic Anemias
Macrocytic Anemia
Hemoglobinopathies
Sickle Cell Anemia
The Thalassemias
Glucose 6-Phosphate Dehydrogenase Deficiency (G6PD)
Favism
Clinical Aspects of Clotting
Vitamin K and Anticoagulants
Hemophilia
Thrombocytopenia and Thrombocytosis
Summary
Further Reading
Disorders of the Cardiovascular System
Introduction
The Heart and Circulatory Systems
Blood Vessels
Arteries
Veins
Capillaries
Blood Pressure
Investigating Cardiac Function in Health and Disease
The Electrocardiogram (ECG)
Echocardiography
Cardiac Catheterization (Angiography)
Angiography and Radiographic Visualization
Exercise Stress Test
Endocarditis
Abnormal Heart Rhythms
Atrial Fibrillation and Flutter
Ventricular Tachycardia
Ventricular Fibrillation
Heart Block
Cardic Failure
Investigation
Treatment
Chronic Heart Failure
Acute Heart Failure
Ischemic Heart Disease
Cardiomyopathies
Dilated Congestive Cardiomyopathy
Hypertrophic Cardiomyopathy
Restrictive Cardiomyopathy
Heart Valve Disorders
Heart Tumors
Atherosclerosis or Arteriosclerosis
Angina
Cholesterol and Lipoproteins
Myocardial Infarction
Plasma Enzymes in Myocardial Infarction
Treatment
Coronary Bypass Surgery
Pericardial Diseases
Disorders of Arteries and Veins
Peripheral Arterial Disease
Aneurysms
Aortic Dissection
Stroke
Varicose Veins
Deep Vein Thrombosis
Clinical Problems Associated with Blood Pressure
Low Blood Pressure (Hypotension)
Shock
High Blood Pressure (Hypertension)
Summary
Further Reading
Genetic Diseases
Introduction
Genetics and DNA
DNA Replication and the Cell Cycle
Mitosis and Meiosis
Genotype and Phenotype
Inheritance and Mutations
Sex-linked Genetic Diseases
Inherited Gene Disorders
Consequences of an Enzyme Deficiency
National Screening Programs for Inherited Diseases
Chromosomes and the Human Karyotype
Fragile Sites
Chromosomal Mutations or Aberrations
Deletions
Duplications
Inversions
Translocations
Variations in Chromosome Numbers
Aneuploidy
Euploidy
Detecting, Diagnosing and Screening Human Genetics Diseases
Detection of Hereditary Diseases
Summary
Further Reading
Membrane, Organelle and Cytoskeletal Disorders
Introduction
Nucleus and Nucleocytoplasmic Transport
Clinical Aspects of Nucleocytoplasmic Transport
Plasma Membrane Disorders
Cystic Fibrosis
Mitochondrial Disorders
Causes of Mitochondrial Disorders
Diagnosis and Treatment of Mitochondrial Disorders
Peroxisomal Disorders
Diagnosis and Treatment of Peroxisomal Disorders
Lysosomal Disorders
Diagnosis and Treatment of Lysosomal Storage Disorders
Cytoskeletal Disorders
Muscular Dystrophies
Hereditary Elliptocytosis and Spherocytosis
Summary
Further Reading
Cancer
Introduction
Classification of Cancer Types
Epidemiology of Cancer
Molecular Biology of Cancer
Oncogenes
Tumor Suppressor Genes
Causes of Cancer
Inherited Cancers
Chromosomes and Cancer
Chemical Carcinogens
Diet and Cancer
Radiation and Cancer
Viruses and Cancer
General Diagnosis of Cancer
Clinical Tests for Cancer
General Treatment of Cancer
Chemotherapy
Radiation Therapy
Immunotherapy
Specific Types of Cancers
Lung Cancer
Breast Cancer
Prostate Cancer
Colorectal Cancer
Leukemias
Summary
Further Reading
Aging and Disease
Introduction
Aging of Cells, Tissues, Organs and Systems
Cells
Tissues
Organs
Systems
Causes of Aging
'Wear and Tear' Theories
Genome-Based Theories
Age-Related Diseases
Cancer
Cardiovascular Disease
Diabetes Mellitus Type 2
Cataracts
Arthritis
Parkinson's Disease
Calorie Restriction and Aging
Investigations and Management of the Elderly
Summary
Further Reading
Case Study Discussions
Answers to Questions
Index
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