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Introduction to Drug Metabolism

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ISBN-10: 0748760113

ISBN-13: 9780748760114

Edition: 3rd 2002 (Revised)

Authors: G. Gordon Gibson, Paul Skett

List price: $63.50
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Description:

Looks at both biochemical and physiological angles. Examples maintain clinical relevance so practical importance of subject can be appreciated.
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Book details

List price: $63.50
Edition: 3rd
Copyright year: 2002
Publisher: Nelson Thornes Limited
Publication date: 10/30/2001
Binding: Paperback
Pages: 256
Size: 6.00" wide x 9.00" long x 0.50" tall
Weight: 1.100

Pathways of drug metabolism
Phase 1 metabolism
Phase 2 metabolism
Summary of drug-metabolising reactions
Endogenous metabolism related to drug metabolism
Enzymology and molecular mechanisms of drug metabolism reactions
Cytochrome P450-dependent mixed-function oxidation reactions
Microsomal flavin-containing monooxygenase
Prostaglandin synthetase-dependent co-oxidation of drugs
Reductive drug metabolism
Epoxide hydrolase
Glucuronide conjugation reactions
Glutathione-S-transferase
Sulfate conjugation
Amino acid conjugation
Control and interactions of drug metabolism pathways
Induction and inhibition of drug metabolism
Induction of drug metabolism
Inhibition of drug metabolism
Biological significance of induction and inhibition of drug metabolism
Factors affecting drug metabolism: internal factors
Species differences
Genetic differences
Age
Hormonal control of drug metabolism
The effects of disease on drug metabolism
Factors affecting drug metabolism: external factors
Dietary factors
Environmental factors
Relative importance of physiological and environmental factors in determining drug-metabolising capacity in the human population
Pharmacological and toxicological aspects of drug metabolism
Pharmacological aspects of drug metabolism
Toxicological aspects of xenobiotic metabolism
Balance of toxifying and detoxifying pathways
Assessment of human drug metabolising enzymes in pharmacology and toxicology
The clinical relevance of drug metabolism
Pharmacokinetics
Methods for studying drug metabolism in man
Clinical relevance of drug metabolism
Index