Introduction to Drug Metabolism

Name: Introduction to Drug Metabolism
Price: 10.53 USD
Availability: InStock
ISBN: 9780748760114

ISBN-10: 0748760113

ISBN-13: 9780748760114

Edition: 3rd 2002 (Revised)

Authors: Paul Skett, David Miell-Ingram

List price: $63.50

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Looks at both biochemical and physiological angles. Examples maintain clinical relevance so practical importance of subject can be appreciated.

Book details

List price: $63.50
Edition: 3rd
Copyright year: 2002
Publisher: Nelson Thornes Limited
Publication date: 10/30/2001
Binding: Paperback
Pages: 256
Size: 6.00" wide x 9.00" long x 0.50" tall
Weight: 0.880




Pathways of drug metabolism


Phase 1 metabolism


Phase 2 metabolism


Summary of drug-metabolising reactions


Endogenous metabolism related to drug metabolism



Enzymology and molecular mechanisms of drug metabolism reactions


Cytochrome P450-dependent mixed-function oxidation reactions


Microsomal flavin-containing monooxygenase


Prostaglandin synthetase-dependent co-oxidation of drugs


Reductive drug metabolism


Epoxide hydrolase


Glucuronide conjugation reactions


Glutathione-S-transferase


Sulfate conjugation


Amino acid conjugation


Control and interactions of drug metabolism pathways



Induction and inhibition of drug metabolism


Induction of drug metabolism


Inhibition of drug metabolism


Biological significance of induction and inhibition of drug metabolism



Factors affecting drug metabolism: internal factors


Species differences


Genetic differences


Age


Hormonal control of drug metabolism


The effects of disease on drug metabolism



Factors affecting drug metabolism: external factors


Dietary factors


Environmental factors


Relative importance of physiological and environmental factors in determining drug-metabolising capacity in the human population



Pharmacological and toxicological aspects of drug metabolism


Pharmacological aspects of drug metabolism


Toxicological aspects of xenobiotic metabolism


Balance of toxifying and detoxifying pathways


Assessment of human drug metabolising enzymes in pharmacology and toxicology



The clinical relevance of drug metabolism


Pharmacokinetics


Methods for studying drug metabolism in man


Clinical relevance of drug metabolism


Index