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Nuclear Medicine in Pharmaceutical Research

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ISBN-10: 0748406883

ISBN-13: 9780748406883

Edition: 1999

Authors: A. C. Perkins, M. Frier

List price: $230.00
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Description:

Radioactive tracers are playing an increasingly important role in the study of drug formulation and drug delivery systems, ranging from the discovery of new drugs to the "in vivo" evaluation of drug delivery in humans. This text defines the role and scope of nuclear medicine imaging techniques (gamma scintigraphy) in pharmaceutical research, giving information from clinical trial data. As the editors state, no other technique can localise so precisely the site of disintegration of a tablet in the gastro intestinal tract, the penetration of an aerosol in the lung or the residence time of a drug on the cornea. There are 10 chapters covering all aspects of scintigraphic imaging applied to pharmaceutical research, ranging from the regulatory requirements, ethical submission and study approval in normal human subjects and patients groups, through to detailed descriptions of specific applications. The introductory chapters provide descriptions of the basic instrumentation, techniques, the principles of GMP appliedto radiolabelling procedures and the importance of validation of products and procedures.
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Book details

List price: $230.00
Copyright year: 1999
Publisher: CRC Press LLC
Publication date: 2/10/1999
Binding: Hardcover
Pages: 208
Size: 7.00" wide x 10.00" long x 0.50" tall
Weight: 1.188
Language: English

Ethical and Regulatory Approval for Human Studies
Instrumentation, Imaging, Data Analysis and Display
Good Manufacturing Practice in the Preparation of Pharmaceutical Dosage Forms for Scintigraphic Evaluation
Drug Delivery to the Respirotory Tract
Scintigraphic Study of Oesphagael Transit and Retention
Scintigraphic Study of Drug Delivery to the Stomach and Small Bowel
Scintigraphic Study of Colonic Release and Absorption
Scintigraphic Study of Ocular Drug Delivery
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