Nuclear Medicine in Pharmaceutical Research
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Radioactive tracers are playing an increasingly important role in the study of drug formulation and drug delivery systems, ranging from the discovery of new drugs to the "in vivo" evaluation of drug delivery in humans. This text defines the role and scope of nuclear medicine imaging techniques (gamma scintigraphy) in pharmaceutical research, giving information from clinical trial data. As the editors state, no other technique can localise so precisely the site of disintegration of a tablet in the gastro intestinal tract, the penetration of an aerosol in the lung or the residence time of a drug on the cornea. There are 10 chapters covering all aspects of scintigraphic imaging applied to pharmaceutical research, ranging from the regulatory requirements, ethical submission and study approval in normal human subjects and patients groups, through to detailed descriptions of specific applications. The introductory chapters provide descriptions of the basic instrumentation, techniques, the principles of GMP appliedto radiolabelling procedures and the importance of validation of products and procedures.
List price: $230.00
Copyright year: 1999
Publisher: CRC Press LLC
Publication date: 2/10/1999
Size: 7.00" wide x 10.00" long x 0.50" tall
|Ethical and Regulatory Approval for Human Studies|
|Instrumentation, Imaging, Data Analysis and Display|
|Good Manufacturing Practice in the Preparation of Pharmaceutical Dosage Forms for Scintigraphic Evaluation|
|Drug Delivery to the Respirotory Tract|
|Scintigraphic Study of Oesphagael Transit and Retention|
|Scintigraphic Study of Drug Delivery to the Stomach and Small Bowel|
|Scintigraphic Study of Colonic Release and Absorption|
|Scintigraphic Study of Ocular Drug Delivery|