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Structure and Development | |
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Muscle Architecture and Muscle Fiber Anatomy | |
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Muscle Architecture | |
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Muscle Connective Tissue | |
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Basement Membrane | |
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Plasmalemma | |
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Myofibrils | |
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Tubular Systems | |
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Nuclei and Mitochondria | |
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Applied Physiology | |
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The Motoneuron | |
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General Features of Motoneurons | |
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Motoneuron Soma | |
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Cytoskeletal Proteins in the Motoneuron | |
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Axon, Dendrites, and Glia | |
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Applied Physiology | |
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The Neuromuscular Junction | |
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General Features of the Neuromuscular Junction | |
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Muscle Fiber Acetylcholine Receptors | |
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The Basement Membrane at the Neuromuscular Junction | |
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Axon Terminal | |
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Applied Physiology | |
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Muscle Receptors | |
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The Muscle Spindle | |
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The Golgi Tendon Organ | |
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Free Nerve Endings | |
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Role of Muscle Receptors During Locomotor Activity | |
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Applied Physiology | |
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Muscle Formation | |
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Mesoderm Is Induced from Ectoderm | |
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A Portion of Mesoderm Forms Somites, Then Develops Into Skeletal Muscle | |
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The Myogenic (Muscle Forming) Cells Proliferate and Then Differentiate | |
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The Body Plan Is Laid Down | |
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Muscles Are Assembled | |
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Postnatal Development of Muscle | |
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Applied Physiology | |
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Development of Muscle Innervation | |
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Inductive Signals Pass From Mesoderm to Ectoderm | |
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The Neural Tube Forms From Thickening and Invagination of the Dorsal Ectoderm | |
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Nerve Cells Proliferate and Then Migrate | |
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Axons Grow Out From the Spinal Cord Along the Extracellular Matrix | |
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The Axons Establish Connections With the Muscle Fibers | |
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Redundant Synapses and Motoneurons Are Eliminated | |
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Applied Physiology | |
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Putting Muscles to Work | |
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Ion Channels, Pumps, and Binding Proteins | |
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General Properties of Channels and Pumps | |
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Sodium Channels | |
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The Sodium Pump (Na+-K+ Pump) | |
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Potassium Channels | |
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Calcium Channels and Pumps | |
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Calcium-Binding Proteins | |
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Calcium Pumps | |
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Anion Channels | |
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Applied Physiology | |
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Axoplasmic Transport | |
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Confirmation and Categorization of Axoplasmic Transport | |
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Applied Physiology | |
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Resting and Action Potentials | |
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Resting Membrane Potential | |
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The Action Potential | |
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Applied Physiology | |
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Neuromuscular Transmission | |
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Acetylcholine Release | |
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Postsynaptic Events | |
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Applied Physiology | |
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Muscle Contraction | |
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Sliding Filament Theory of Muscle Contraction | |
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The Cross-Bridge Theory of Skeletal Muscle | |
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The Key Contractile Proteins: Myosin and Actin | |
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Excitation-Contraction Coupling | |
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The Contractile Response | |
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The Length Dependence of Force | |
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Dynamic Contractions | |
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Applied Physiology | |
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Motor Units | |
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Organization of Motor Units | |
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Physiological and Biochemical Properties of Motor Units | |
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Classification of Motor Units | |
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Applied Physiology | |
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Motor Unit Recruitment | |
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Detection of Motor Unit Activation | |
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The Size Principle | |
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Maximal Voluntary Contraction | |
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Applied Physiology | |
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Muscle Metabolism | |
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Energy Required for Muscle Contraction | |
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Replacing Adenosine Triphosphate | |
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Integration of the Metabolic Systems | |
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Regulation of the Metabolic Systems | |
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How Much Energy Is Needed? | |
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Applied Physiology | |
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The Adaptable Neuromuscular System | |
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Fatigue | |
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Defining Fatigue | |
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Central Fatigue | |
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Peripheral Fatigue | |
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Excitation-Contraction Coupling Failure | |
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Biochemical Changes in Muscle Fibers | |
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Recovery From Fatigue | |
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Applied Physiology | |
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Loss of Muscle Innervation | |
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Changes in Motor Axons and Neuromuscular Junctions | |
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Changes in Muscle Fibers | |
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Applied Physiology | |
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Recovery of Muscle Innervation | |
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Nerve Regeneration | |
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Collateral Reinnervation | |
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Changes in the Muscle Fibers Following Reinnervation | |
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Motor Unit Properties Following Reinnervation | |
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Applied Physiology | |
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Trophism | |
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Motoneuron Effects on Muscle | |
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Muscle Effects on Motoneurons | |
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Applied Physiology | |
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Disuse | |
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Studies in Human Subjects | |
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Studies in Animals | |
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Applied Physiology | |
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Muscle Training | |
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Muscle Strength and Power | |
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Human Endurance Training | |
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Training Studies in Animals | |
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Adaptive Changes in DNA and RNA Processing | |
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Applied Physiology | |
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Injury and Repair | |
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Muscle Contraction-Induced Damage | |
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Muscle Injury From External Causes | |
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Applied Physiology | |
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Aging | |
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Changes in Muscle With Aging | |
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Motoneuron Changes in Aging | |
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Changes in Axons and Neuromuscular Junctions | |
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Applied Physiology | |