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Neurochemistry of Sleep and Wakefulness

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ISBN-10: 0521864410

ISBN-13: 9780521864411

Edition: 2008

Authors: Jaime Monti, Christopher M. Sinton, S. R. Pandi-Perumal

List price: $140.00
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Description:

Pharmacological approaches to our understanding of sleep have been at the forefront of sleep research for many years. Traditional techniques have included the use of pharmacological agonists and antagonists, as well as transmitter-specific lesions. These have been enhanced by the introduction of molecular genetics and the use of transgenes and targeted gene deletion. Neurochemistry of Sleep and Wakefulness is an exceptional, single source of information on the role of the major mammalian neurotransmitter systems involved in the regulation of sleep and waking. With contributions from internationally recognized experts, this book clearly describes how researchers have made use of the myriad techniques in their armamentarium to characterize the role of a given neurotransmitter in the regulation of sleep and waking. Suitable for experimental and clinical pharmacologists, the book will have wider appeal to sleep researchers, psychiatrists and any professional interested in the interdisciplinary areas of neurobiology and pharmacology.
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Book details

List price: $140.00
Copyright year: 2008
Publisher: Cambridge University Press
Publication date: 1/17/2008
Binding: Hardcover
Pages: 506
Size: 7.00" wide x 9.75" long x 1.00" tall
Weight: 2.596
Language: English

List of contributors
Preface
Acknowledgements
Abbreviations
The neurochemistry of the states of sleep and wakefulness
Neurochemistry of the preoptic hypothalamic hypnogenic mechanism
Neuroanatomical and neurochemical basis of wakefulness and REM sleep systems
Rapid eye movement sleep regulation by modulation of the noradrenergic system
The influence of neurotransmitters on sleep and wakefulness
Gamma-aminobutyric acid and the regulation of paradoxical, or rapid eye movement, sleep
Acetylcholine modulates sleep and wakefulness: a synaptic perspective
Histamine in the control of sleep-wakefulness
Dopamine in behavioral state control
Glutamate neurotransmission and sleep
Serotonin and sleep-wake regulation
Changing perspectives
Melatonin and its receptors: biological function in circadian sleep-wake regulation
Sleep regulatory factors
Adenosine and sleep-wake regulation
Prostaglandins and the regulation of sleep and wakefulness
Neuropeptides and sleep-wake regulation
Orexins in sleep and wakefulness: rodent models of narcolepsy-cataplexy
The relevance of experimental pharmacology to currently available sleep-wake therapeutics
Index