Dynamic Bacterial Genome
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This book provides an in-depth analysis of the mechanisms and biological consequences of genome rearrangements in bacteria. Genome rearrangements are a result of the actions of discrete genetic elements such as conjugative transposons, plasmids, phage, and non conjugative transposons. Bacteria also contain systems to mediate genetic rearrangements such as the general recombination pathway and specialized endogenous recombination mechanisms. The biological effects of these rearrangements are far-reaching and impact on bacterial virulence, antibiotic resistance and the ability of bacteria to avoid the attentions of the host immune system (e.g. antigenic variation). These rearrangements also provide the raw material on which natural selection can act. Each chapter examines the mechanisms involved in genome rearrangements and the direct biological consequences of these events. This book is written by leading research workers and will be an invaluable resource for graduate students and researchers in this field.
List price: $234.99
Copyright year: 2005
Publisher: Cambridge University Press
Publication date: 9/26/2005
Size: 9.25" wide x 6.25" long x 1.00" tall
|Basic Mechanisms of Genome Rearrangement in Bacteria|
|Mechanisms of Homologous Recombination in Bacteria|
|Introduction to site-specific recombination|
|Site-specific recombination by the serine recombinases|
|Mobile introns and retroelements in bacteria|
|Horizontal Gene Transfer and Genome Plasticity|
|The F-Plasmid, a paradigm for bacterial conjugation|
|Molecular aspects of movement of conjugative transposons|
|Competence for genetic transformation|
|Biological Consequences of the Mobile Genome|
|Phase variation and antigenic variation|
|Biological Consequences for bacteria of homologous recombination|
|Horizontal gene transfer and bacterial genomic legacies|