Consequences of Chromosome Imbalance Principles, Mechanisms, and Models
List price: $96.00
This item qualifies for FREE shipping.
30 day, 100% satisfaction guarantee!
Rush Rewards U
You have reached 400 XP and carrot coins. That is the daily max!
This is the first book to consider in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioral problems and malignancy. In The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models, Charles J. Epstein concerns himself with how and why a particular chromosome imbalance produces a specific phenotype. His fundamental goal is to connect chromosome aberrations with functional abnormalities in terms of gene expression, developmental and cell biology, and metabolism. Through his examination of this relationship, we learn more about normal development and function. The book begins with an exploration of several human autosomal aneuploid phenotypes, with particular emphasis on the relationship between genotype and phenotype. In the next part, broad theoretical considerations of the mechanisms which generate these phenotypes are examined with reference to studies on man and other organisms such as bacteria and mice. Experimental approaches to study the effects of aneuploidy are presented next with special attention paid to the development of model systems for studying human aneuploidy.
List price: $96.00
Copyright year: 2007
Publisher: Cambridge University Press
Publication date: 7/26/2007
Size: 6.10" wide x 9.21" long x 0.98" tall
|The problem of aneuploidy|
|The differentiability and variability of phenotypes|
|The partitioning of phenotypes|
|The Theoretical Mechanisms and Issues: The Primary and Secondary Effects of Aneuploidy|
|Gene dosage effects|
|Metabolic pathways, transport systems, and receptors|
|Assembly of macromolecules, cellular interactions, and pattern formation|
|Type and countertype|
|Nonspecific effects of aneuploidy|
|Experimental Systems for the Study of Mammalian and Human Aneuploidy|
|Generation and properties of mouse aneuploids|
|Models for human aneuploidy|
|Three Major Clinical Problems of Human Aneuploidy|
|Trisomy 21 (down syndrome)|
|Monosomy X (turner syndrome, gonadal dysgenesis)|
|Principles, mechanisms, and models|