Consequences of Chromosome Imbalance Principles, Mechanisms, and Models

Name: Consequences of Chromosome Imbalance Principles, Mechanisms, and Models
Price: 70.48 USD
Availability: InStock
ISBN: 9780521038096

ISBN-10: 052103809X

ISBN-13: 9780521038096

Edition: 2007

Authors: Charles J. Epstein

List price: $71.99

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Description:

This is the first book to consider in detail the mechanisms of a major human problem. Chromosome imbalance affects all stages of life in ways ranging from spontaneous abortion and retardation to behavioral problems and malignancy. In The Consequences of Chromosome Imbalance: Principles, Mechanisms, and Models, Charles J. Epstein concerns himself with how and why a particular chromosome imbalance produces a specific phenotype. His fundamental goal is to connect chromosome aberrations with functional abnormalities in terms of gene expression, developmental and cell biology, and metabolism. Through his examination of this relationship, we learn more about normal development and function. The…

Book details

List price: $71.99
Copyright year: 2007
Publisher: Cambridge University Press
Publication date: 7/26/2007
Binding: Paperback
Pages: 512
Size: 6.10" wide x 9.21" long x 0.98" tall
Weight: 1.562
Language: English



Preface


Glossary



Introduction



The problem of aneuploidy



Clinical Observations



The differentiability and variability of phenotypes



The partitioning of phenotypes



The Theoretical Mechanisms and Issues: The Primary and Secondary Effects of Aneuploidy



Gene dosage effects



Metabolic pathways, transport systems, and receptors



Regulatory systems



Assembly of macromolecules, cellular interactions, and pattern formation



Type and countertype



Nonspecific effects of aneuploidy



Experimental Systems for the Study of Mammalian and Human Aneuploidy



Generation and properties of mouse aneuploids



Models for human aneuploidy



Three Major Clinical Problems of Human Aneuploidy



Trisomy 21 (down syndrome)



Monosomy X (turner syndrome, gonadal dysgenesis)



Cancer



Conclusion



Principles, mechanisms, and models


Appendix


References


Index