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Immunology A Short Course

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ISBN-10: 0471226890

ISBN-13: 9780471226895

Edition: 5th 2003 (Revised)

Authors: Richard Coico, Geoffrey Sunshine, Eli Benjamini

List price: $69.95
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Description:

Now in its FIFTH EDITION, this widely acclaimed textbook has been updated and revised to incorporate new findings. Providing a concise yet thorough introduction to immunology, this text continues to provide complete coverage of all key topics in modern immunology without overburdening the reader with excessive detail or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics illustrated by uniformly drawn, full color illustrations. In addition to updating all of the chapters, IMMUNOLOGY: A SHORT COURSE, FIFTH EDITION includes completely rewritten coverage of such key topics as complement, immunodeficiencies, and lymphoid neoplasms. Written…    
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Book details

List price: $69.95
Edition: 5th
Copyright year: 2003
Publisher: John Wiley & Sons, Incorporated
Publication date: 10/21/2003
Binding: Paperback
Pages: 392
Size: 11.00" wide x 8.50" long x 0.50" tall
Weight: 1.738
Language: English

About the Authors
Contributors
Preface and Acknowledgments to the Fifth Edition
Preface and Acknowledgments to the Fourth Edition
Preface and Acknowledgments to the Third Edition
Preface to the Second Edition
Preface to the First Edition
Introduction and Overview
Introduction
Overview
References
Elements of Innate and Acquired Immunity
Introduction
Innate Immunity
Adaptive (Acquired) Immunity
Cells and Organs Involved in the Adaptive Immune Response
Lymphocyte Recirculation
The Fate of Antigen After Penetration
Interrelationship Between Innate and Acquired Immunity
Summary
References
Review Questions
Answers to Review Questions
Immunogens and Antigens
Introduction
Requirements for Immunogenicity
Primary and Secondary Responses
Antigenicity and Antigen-Binding Site
Epitopes Recognized by B Cells and T Cells
Major Classes of Antigens
Binding of Antigen with Antigen-Specific Antibodies or T Cells
Cross-Reactivity
Adjuvants
Summary
References
Review Questions
Answers to Review Questions
Antibody Structure and Function
Introduction
Isolation and Characterization
Structure of Light and Heavy Chains
Domains
Hinge Region
Variable Region
Immunoglobulin Variants
Allotypes
Structural Features of IgG
Biologic Properties of IgG
Structural Features of IgM
Biologic Properties of IgM
Structural and Biologic Properties of IgA
Structural and Biologic Properties of IgD
Structural and Biologic Properties of IgE
Kinetics of the Antibody Response After Immunization
The Immunoglobulin Superfamily
Summary
References
Review Questions
Answers to Review Questions
Antigen-Antibody Interactions, Immune Assays, and Experimental Systems
Introduction
Antigen-Antibody Interactions
Primary Interactions Between Antibody and Antigen
Secondary Interactions Between Antibody and Antigen
Immunoassays
Immunofluorescence
Fluorescence-Activated Cell-Sorting Analysis
Immunoabsorption and Immunoadsorption
Cellular Assays
Cell Culture
Experimental Animal Models
Transgenic Mice and Gene Targeting
Analysis of Gene Expression
Summary
References
Review Questions
Answers to Review Questions
The Genetic Basis of Antibody Structure
Introduction
A Brief Review of Nonimmunoglobulin Gene Structure and Gene Expression
Genetic Events in the Synthesis of Ig Chains
Class or Isotype Switching
Generation of Antibody Diversity
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answer to Case Study
Biology of the B Lymphocyte
Introduction
Ontogeny of the B Lymphocyte
B Cell Membrane Proteins
Summary
References
Review Questions
Answers to Review Questions
Biology of the T Lymphocyte
Introduction
Nature of the Antigen-Specific T Cell Receptor
Genes Coding for T Cell Receptors
Generation of T cell Receptor Diversity
T Cell Differentiation in the Thymus
T Cell Receptor Gene Rearrangements
Thymic selection
Summary
References
Review Questions
Answers to Review Questions
The Role of the Major Histocompatibility Complex in the Immune Response
Introduction
MHC Genes and Products
Variability of MHC Genes and Products
Structure of MHC Molecules
The Function of MHC Molecules: Antigen Processing and Presentation
Diversity of MHC Molecules: MHC Association with Resistance and Susceptibility to Disease
Other Genes Within the MHC Region
Summary
References
Review Questions
Answers to Review Questions
Activation and Function of T and B Cells
Introduction
Activating CD4[superscript +] T Cells
Other Ways To Activate T Cells
T Cell Function
Function of CD8[superscript +] T Cells
B-Cell Function in the Absence of T Cell Help
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answer to Case Study
Cytokines
Introduction
The History of Cytokines
General Properties of Cytokines
Functional Categories of Cytokines
Cytokine Receptors
Cytokine Receptor-Mediated Signal Transduction
Role of Cytokines and Cytokine Receptors in Disease
Therapeutic and Diagnostic Exploitation of Cytokines and Cytokine Receptors
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answer to Case Study
Tolerance and Autoimmunity
Central Tolerance
Peripheral Tolerance
Fas-Fas L interactions
Regulatory/Suppressor T Cells
Oral Tolerance
Immune Privilege
Autoimmunity and Disease
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answers to Case Study
Complement
Introduction
Complement Activation Pathways
Regulation of Complement Activity
Biologic Activities of Complement
Complement Deficiencies
Summary
References
Review Questions
Answers to Review Questions
Hypersensitivity Reactions: Antibody-Mediated (Type I) Reactions
Introduction
General characteristics of Allergic Reactions
Sensitization Phase
Activation Phase
Effector Phase
Clinical Aspects of Allergic Reactions
Clinical Tests for Allergies and Clinical Intervention
The Protective Role of IgE
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answer to Case Study
Hypersensitivity Reactions: Antibody-Mediated (Type II) Cytotoxic Reactions and Immune Complex (Type III) Reactions
Introduction
Examples of Cytotoxic Hypersensitivity Reactions
Immune Complex Reactions: Type III Hypersensitivity
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answer to Case Study
Hypersensitivity Reactions: T Cell-Mediated (Type IV) Delayed-Type Hypersensitivity
Introduction
General Characteristics and Pathophysiology of DTH
Examples of DTH
Treatment of DTH
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answer to Case Study
Immunodeficiency Disorders and Neoplasias of the Lymphoid System
Introduction
Immune Deficiency Syndromes
Acquired Immunodeficiency Syndrome (AIDS)
Neoplasms of the Lymphoid System
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answer to Case Study
Transplantation
Introduction
Relationship between Donor and Recipient
Immune Mechanisms and Allograft Rejection
Responses to Alloantigens and Allograft Rejection
Role of MHC Molecules in Allograft Rejection
Laboratory Tests Used in Tissue Typing
Prolongation of Allograft Survival
Bone Marrow and Hematopoietic Stem Cell Transplantation
Graft versus Host Reactions
Xenogeneic Transplantation
The Fetus: A Tolerated Allograft
Heart Transplantation: A Personal Story
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answer to Case Study
Tumor Immunology
Introduction
Tumor Antigens
Categories of Tumor Antigens
Effector Mechanisms in Tumor Immunity
Limitations of the Effectiveness of the Immune Response Against Tumors
Immunodiagnosis
Tumor Immunoprophylaxis
Immunotherapy
Summary
References
Review Questions
Case Study
Answers to Review Questions
Answer to Case Study
Resistance and Immunization to Infectious Diseases
Introduction
Host Defense Against the Various Classes of Microbial Pathogens
Mechanisms by which Pathogens Evade the Immune Response
Principles of Immunization
Objectives of Immunization
Active Immunizations
Basic Mechanisms of Protection
Precautions
Recent Approaches to Production of Vaccines
Passive Immunization
Summary
References
Review Questions
Answers to Review Questions
Glossary
Partial List of CD Antigens
Index