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| Preface | |
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| Acknowledgements | |
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| Abbreviations and acronyms | |
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| General principles | |
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| What is pharmacology? | |
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| How drugs act: general principles | |
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| How drugs act: molecular aspects | |
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| How drugs act: cellular aspects-excitation, contraction and secretion | |
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| Cell proliferation and apoptosis | |
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| Method and measurement in pharmacology | |
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| Absorption and distribution of drugs | |
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| Drug elimination and pharmacokinetics | |
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| Chemical mediators | |
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| Chemical mediators and the autonomic nervous system | |
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| Cholinergic transmission | |
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| Noradrenergic transmission | |
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| Other peripheral mediators: 5-hydroxytryptamine and purines | |
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| Local hormones, inflammation and immune reactions | |
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| Anti-inflammatory and immunosuppressant drugs | |
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| Cannabinoids | |
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| Peptides and proteins as mediators | |
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| Nitric oxide | |
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| Drugs affecting major organ systems | |
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| The heart | |
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| The vascular system | |
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| Atherosclerosis and lipoprotein metabolism | |
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| Haemostasis and thrombosis | |
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| The haemopoietic system | |
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| The respiratory system | |
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| The kidney | |
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| The gastrointestinal tract | |
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| The endocrine pancreas and the control of blood glucose | |
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| Obesity | |
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| The pituitary and the adrenal cortex | |
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| The thyroid | |
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| The reproductive system | |
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| Bone metabolism | |
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| The nervous system | |
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| Chemical transmission and drug action in the central nervous system | |
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| Amino acid transmitters | |
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| Other transmitters and modulators | |
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| Neurodegenerative diseases | |
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| General anaesthetic agents | |
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| Anxiolytic and hypnotic drugs | |
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| Antipsychotic drugs | |
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| Antidepressant drugs | |
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| Antiepileptic drugs | |
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| Analgesic drugs | |
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| CNS stimulants and psychotomimetic drugs | |
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| Drug addiction, dependence and abuse | |
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| Local anaesthetics and other drugs affecting sodium channels | |
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| Drugs used in the treatment of infections and cancer | |
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| Drugs used in the treatment of infections and cancer | |
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| Antibacterial drugs | |
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| Antiviral drugs | |
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| Antifungal drugs | |
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| Antiprotozoal drugs | |
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| Antihelminthic drugs | |
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| Cancer chemotherapy | |
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| Special topics | |
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| Individual variation and drug interaction | |
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| Harmful effects of drugs | |
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| Lifestyle drugs and drugs in sport | |
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| Biopharmaceuticals and gene therapy | |
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| Drug discovery and development | |
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| Appendix | |
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| Index | |