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| Abbreviations | |
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| Dedication | |
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| Preface | |
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| Introduction | |
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| Nucleic acids in human cells | |
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| Nucleic acid structure in micro organisms | |
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| Methods | |
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| Hybridization detection methods | |
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| Types of probes | |
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| Polymerase chain reaction | |
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| Separation methods | |
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| Chromosome and tissue analysis | |
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| Some pitfalls in nucleic acid diagnosis | |
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| Future diagnostic research | |
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| Human genetic diseases | |
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| Types of genetic disease and patterns of inheritance | |
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| Markers used in linkage analysis | |
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| DNA for prenatal diagnosis | |
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| Detecting known mutations | |
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| Karyotyping for trisomies and translocations | |
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| Single cell detection of genetic disorders in embryos by PCR | |
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| Polygenic disorders | |
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| Automated analysis for common mutations | |
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| Associations of particular alleles and disease states in the population | |
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| Cancers | |
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| Infectious diseases I - viruses | |
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| Sample collection and preparation | |
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| Detection of virus | |
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| Quantitative viral estimation | |
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| Measurement of antiviral resistance | |
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| Detection of novel agents of disease | |
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| Commercial systems | |
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| Human infectious diseases II - bacteria, fungi and protozoa | |
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| Specimen collection and preparation | |
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| Identification | |
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| Commercial systems | |
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| Typing of isolates | |
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| Antimicrobial resistance | |
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| Novel and noncultivatable bacteria | |
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| Fungi | |
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| Protozoa | |
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| Future prospects | |
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| Applications of nucleic acid diagnosis in pathology[superscript a] | |
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| Which pathological processes can we detect by nucleic acid methods? | |
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| Tumor diagnosis | |
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| Nucleic acid-based methods for the detection and diagnosis of cancer | |
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| Investigating lymphoma | |
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| Southern blotting technique to detect gene rearrangements | |
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| Detection of translocations | |
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| Future developments | |
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| Nucleic acid analysis of historical samples | |
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| The historical limits of DNA detection | |
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| Reasons for false results | |
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| Future possibilities | |
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| Index | |