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Principles and Practice of Clinical Electrophysiology of Vision

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ISBN-10: 0262083469

ISBN-13: 9780262083461

Edition: 2nd 2006

Authors: John R. Heckenlively, Geoffrey B. Arden, Michael Bach, Graham E. Holder, Steven Nusinowitz

List price: $170.00
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Description:

This authoritative text is the only comprehensive reference available on electrophysiologic vision testing, offering both practical information on techniques and problems as well as basic physiology and anatomy, theoretical concepts, and clinical correlations. The second edition, of the widely used text, offers extensive new material and updated information: 65 of the 84 chapters are completely new, with the changes reflecting recent advances in the field. The book will continue to be an essential resource for practitioners and scholars from a range of disciplines within vision science. The contributions not only cover new information--important material that is likely to become more important in the next decade--but also offer a long-range perspective on the field and its remarkable development in the last century. After discussing the history and background of clinical electrophysiology, the book introduces the anatomy of the retina and principles of cell biology in the visual pathways at the molecular, physiological, and biochemical levels. It relates these new findings to the techniques and interpretations of clinical tests, including the electro-oculogram (EOG), electroretinogram (ERG), and visual evoked potentials (VEP), which are discussed in detail, as are equipment, data acquisition and analysis, principles and protocols for clinical testing, diseases and dysfunction, and animal testing. Notable additions for this edition include chapters on the origin of electroretinogram waveforms, multifocal techniques, testing in standard laboratory animals, recent advances in analysis of abnormalities in disease, and the applications of these techniques to the study of genetic abnormalities.
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Book details

List price: $170.00
Edition: 2nd
Copyright year: 2006
Publisher: MIT Press
Publication date: 4/7/2006
Binding: Hardcover
Pages: 1016
Size: 9.00" wide x 11.50" long x 1.75" tall
Weight: 5.346
Language: English

John R. Heckenlively is Paul R. Lichter Professor of Ophthalmic Genetics and Professor of Ophthalmology and Visual Sciences at the University of Michigan Kellogg Eye Center in Ann Arbor.

Geoffrey B. Arden is Professor of Ophthalmology and Visual Sciences, Henry Wellcome Research Laboratories, City University, Northampton Square, London.

History and background to modern testing
History of the Electroretinogram
History of Electro-Oculography
History of Visual Evoked Cortical Testing
Anatomy of the Retina, Principles of Cell Biology in the Visual Pathways: Functional, Physiological, Biochemical, Molecular Biological
The Photoreceptor-Retinal Pigment Epithelium Interface
Membrane Mechanisms of the Retinal Pigment Epitelium
Functional Organization of the Retina
Synaptic Transmission: Sensitivity Control Mechanisms
Phototransduction and Photoreceptor Physiology
Structure and Function of Retinal Synapses: Role of Cell Adhesion Molecules and Extracellular Matrix
Central Disorders of Vision in Humans
Origins of Slow Electrophysiological Components
The Electro-oculogram
Orgins of the Electroretinogram
The Origin of the Pattern Electroretinogram (PERG)
The Multifocal ERG and VEP Techniques
Origin of the VEP Potentials
Equipment
Data Acquisition Systems for Electrodiagnostic Testing
Electrodes for Visual Testing
Amplifiers and Special-Purpose Data Acquisitions Systems
Stimulus Devices, Calibration and Measurement of Light
Data Acquisition
Introduction to the ISCEV Standards
EOG Standard
Standard for Clinical Electroretinography
Standard for Pattern Electroretinography
Visual Evoked Potentials Standard
Guidelines for Basic Multifocal Electroretinography (mfERG)
Multifocal Techniques
The Pattern Electroretinogram
Assessing Infant Acuity, Fusion, and Stereopsis with Visual Evoked Potential
Aging and Pattern Visual Evoked Cortical Potential
Aberrant Albino and Achiasmat Visual Pathways: Noninvasive Electrophysiological Assessment
Clinical psychophysical techniques
Measurement of Contrast Sensitivity
Suppressive Rod-Cone Interaction
The Use of Fluorescein Angiography as an Adjunct to Electrophysiological Testing
Data Analysis
Experimental Design and Data Analyses in Vision Function Testing
Analytical Techniques
Reverse Correlation Methods
Stimulus-Response Functions for the Scotopic b-Wave
Kernel Analysis
Measuring the Health of the Human Photoreceptors with the Leading Edge of the a-Wave
Principles of Clinical Testing
Localizing Lesions in the Visual System
Paired-Flash ERG Analysis of Rod Phototransduction and Adaptation
Hyperabnormal (Supranormal) Electroretinographic Responses
Technical Issues in Evaluating Patients in Therapeutic Trials
Other Protocols for Recording of ERG and Slower Potentials, Technical Issues, and Auxiliary Testing Techniques
Early Receptor Potential
Nonphotic Standing Potential Responses: Hyperosmolarity, Bicarbonate, and Diamox Responses
Direct Current (DC) Electroretinogram
The Oscillatory Potentials of the Electroretinogram
Flicker Electroretinography
Chromatic Recordings of Electroretinograms
Adaptation Effects on the Electroretinogram
Clinical Electrophysiological and Psychophysical Investigations into Color Defects
Causes and Cures of Artifacts
Principles of Clinical Testing and Evaluation of Visual Dysfunction from Developmental, Toxic, and Acquired Causes
Testing Levels of the Visual System
Effects of High Myopia on the Electroretinogram
Electrodiagnostic Testing in Malingering and Hysteria
Developmental Amblyopia
Visually Evoked Potentials in Cortical Blindness
Drug Side Effects and Toxicology of the Visual System
Mitochondrial Diseases
Evaluation of Vascular Diseases, Inflammatory States, and Tumors
Diseases of the Middle Retina: Venous and Arterial Occlusions
Acute Disorders of the Outer Retina, Pigment Epithelium and Choroid
Autoimmune retinopathy, CAR and MAR Syndromes
Ischemic Optic Neuropathy
Clinical Descriptions: Retinal Pigment Epithelium Diseases
Gyrate Atrophy of the Choroid and Retina
Dominant Drusen
Stargardt Disease
Bietti's Crystalline Dystrophy of Cornea and Retina
Leber Congenital Amaurosis
Pattern Dystrophies
Best Vitelliform Macular Dystrophy
Sorsby's Fundus Dystrophy
Diseases of the Outer Retina
Choroideremia
Retinitis Pigmentosa
Cone Dystrophies and Degenerations
Vitamin A Deficiency
Diseases of the Midretina (Including Negative Waveform Diseases)
Differential Diagnosis of the Electronegative Electroretinogram
Juvenile X-Linked Retinoschisis
Congenital Stationary Night Blindness
Quinine Retinopathy
Optic Nerve and Central Nervous System Dysfunction
Leber's Hereditary Optic Neuropathy
The Pattern Electroretinogram in Glaucoma and Ocular Hypertension
Chiasmal and Retrochiasmal Lesions
Optic Nerve and Central Nervous Dysfunctions: Parkinson's Disease and Multiple Sclerosis
Diseases of Fatty Acid Storage and Metabolism: Neuronal Ceroid Lipofuscinoses and the Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency
Animal Testing
Evaluating Retinal Function in the Mouse Retina with the Electroretinogram
ERGs of Dog and Chicken
ERG Testing in Larger Animals
Visual Evoked Potentials in Animals