Mutation Detection

Name: Mutation Detection
Price: 7.7 USD
Availability: InStock
ISBN: 9780198548881

ISBN-10: 0198548885

ISBN-13: 9780198548881

Edition: 1997

Authors: Richard G. H. Cotton

List price: $85.00

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Description:

Cancer and the mechanisms of its development are receiving increasing research interest. New genes are being isolated almost daily, Fundamental to those studies is the ability to detect mutations. Mutation detection is time consuming and expensive and thus should be undertaken with a thorough knowledge of the alternative methods. This book aims to critically review the field, refer to methodology and protocols, and give illustrative examples as well as put the whole emerging field in context, including ethical considerations.

Book details

List price: $85.00
Copyright year: 1997
Publisher: Oxford University Press, Incorporated
Publication date: 1/30/1997
Binding: Hardcover
Pages: 216
Size: 6.31" wide x 9.50" long x 0.63" tall
Weight: 1.122
Language: English




Introduction



Sequencing Methods



Scanning Methods



Physical Methods



Denaturing Gradient Gel Electrophoresis



Single Strand Conformational Polymorphism



Heteroduplex



Mismatch Detection/Cleavage



Ribonuclease



Chemical Cleavage



Carbodiimide



DNA endonucleases and binding proteins



Other



Allele Specific Oligonucleotide



Ligase and LCR



Allele Specific Amplification



Primer Extension



Artificial Introduction of Restriction Sites



Restriction Enzymes



Associated Methodology



Southern Blots



PCRn






Gene Specific Strategies



Current Weaknesses and Future Requirements