Rabies

Name: Rabies
Availability: OutOfStock
ISBN: 9780123790774

ISBN-10: 0123790778

ISBN-13: 9780123790774

Edition: 2002

Authors: Alan C. Jackson, William H. Wunner

List price: $155.00

30 day, 100% satisfaction guarantee!

Out of stock

We're sorry. This item is currently unavailable.

what's this?

Rush Rewards U
Members Receive:

You have reached 400 XP and carrot coins. That is the daily max!

Description:

Rabies is the most current and comprehensive account of one of the oldest diseases known. It continues to remain a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. Since the publication of the first edition five years ago, there have been many new developments on the rabies landscape. This second edition provides a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of the disease. In addition, current methods used in defining the…

Book details

List price: $155.00
Copyright year: 2002
Publisher: Elsevier Science & Technology Books
Publication date: 4/8/2002
Binding: Hardcover
Pages: 800
Size: 6.50" wide x 9.50" long x 0.75" tall
Weight: 1.738
Language: English



Foreword


Preface


Contributors


The History of Rabies


Introduction


Remedies for dog rabies from the early and middle ages to the 18th century


Rabies in the New World


The early role of wild animals in the spread of rabies


Development of the first-generation rabies vaccine


References


Rabies Virus


Introduction


Rabies virus structure


Rabies virus replication


Life cycle of rabies virus infection


Virus cell-to-cell spread - perpetuating the virus life cycle


Structure of rabies virus proteins in relation to function


References


Molecular Epidemiology


Introduction


Methods and definition of terms


Viral taxonomy


Aspects of rabies pathogenesis and evolution revealed by molecular epidemiology


Conclusions and future trends


Acknowledgments


References


Epidemiology


Introduction to concepts


The epidemiology of human rabies


Routes of rabies virus transmission to humans


Risk and prevention of rabies following an exposure


Epidemiology of rabies in mammalian populations


Dissemination of canine rabies and evidence for periodic cycles


Cross-species transmission (spillover) of rabies virus


Spatial spread and epidemiology of wildlife rabies


Control of rabies directed toward mammalian reservoir hosts


References


Rabies in Terrestrial Animals


Introduction


Host range and susceptibility


Transmission


Clinical course


Differential diagnosis


Viral excretion and public health implications


Reservoirs and other lyssaviruses


Rabies in domestic animals


Wildlife reservoirs


Other animals as reservoirs or simply spillover hosts?


Conclusions


References


Bat Rabies


Introduction - general considerations on bat rabies


Bat rabies in the New World


Bat rabies in the Old World


References


Human Disease


Introduction


Exposures, incubation period and prodromal symptoms


Clinical forms of disease


Investigations


Differential diagnosis


Therapy


Recovery from rabies


Rabies due to other Lyssavirus genotypes


References


Pathogenesis


Introduction


Events at the site of exposure


Spread to the CNS


Spread within the CNS


Spread from the CNS


Animal models of rabies virus neurovirulence


Rabies virus receptors


Brain dysfunction in rabies


Recovery from rabies and chronic rabies virus infection


Summary


References


Pathology


Introduction


Macroscopic findings


Pathology in the central nervous system


Pathology in the peripheral nervous system


Pathology involving the eye and extraneural organs


Summary and conclusions


References


Diagnostic Evaluation


Introduction


Post-mortem diagnosis of rabies in animals


Virus isolation


Use of molecular methods to detect viral RNA


Diagnosis of rabies in humans


Rabies antibody assays


Acknowledgements


References


Rabies Serology


Introduction


Investigative serology


Serologic methods


Choosing an assay


Quality assurance measures


Conclusions


References


Immunology


Introduction


Molecular components of a specific immune response


Immune responses during RABV infection


Immunological basis for post-exposure vaccination efficiency


Conclusions


References


Human Rabies Vaccines


Introduction


Value of vaccination


Nerve tissue vaccines


Cell culture vaccines


Conclusions


References


Animal Vaccines


Introduction


Animal rabies vaccines


References


Next Generation Rabies Vaccines


Introduction


Recombinant virus vaccines


DNA-based rabies vaccines


Oral rabies vaccines derived from plants


References


Public Health Management of Humans at Risk


Introduction


Pre-exposure vaccination


Post-exposure vaccination


Adverse reactions to cell culture vaccines


Interchangeability of vaccines


Rabies in children


Travel to canine rabies endemic countries


Rabies control in developing countries


Educational awareness


References


Dog Rabies and its Control


Introduction


The burden of canine rabies


Historical perspectives on dog rabies control


Dog accessibility


Vaccination coverage


The epidemiological theory of dog rabies control


Oral vaccination of dogs


Age at first vaccination


Dog rabies control in wildlife conservation


Economics of dog vaccination for rabies control


Dog population management


Conclusion


Acknowledgments


References


Rabies Control in Wild Carnivores


Introduction


Historical aspects of rabies control in wildlife


The concept of controlling rabies in wildlife


Initiation of wildlife rabies control programs


Diagnosis of suspect wildlife


Vector species biology in relation to rabies epidemiology


Transportation of wildlife


Point infection control: the first call for control


Bait development for delivery of oral rabies vaccine


ORV initiation/considerations


Importance of vector home range and density for vaccine bait distribution


Large-scale vaccine bait distribution technology


Surveillance prior to, during and after a rabies control program


Vaccine baiting costs/benefits and costs of rabies control


Vaccine baiting efficiency and baiting success guidelines


Contingency planning


Modeling


Conclusion


References


Future Developments and Challenges


Introduction


Pathogenesis


Epidemiology


Prevention of human rabies


Diagnosis and therapy of human rabies


Control of animal rabies


Summary


References


Index