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| Contributors | |
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| Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease | |
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| Abstract | |
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| Introduction | |
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| Immunological Alterations in SLE | |
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| Genetics of SLE Susceptibility in Humans | |
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| Murine Models of SLE | |
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| Modeling Disease Development | |
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| References | |
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| Avian Models with Spontaneous Autoimmune Diseases | |
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| Abstract | |
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| Introduction | |
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| Chicken Genomics and Its Application to the Genetic Dissection of Autoimmune Disorders | |
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| The OS Chicken: Model for Human Hashimoto Disease | |
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| The UCD-200 Line of Chickens: A Model for Human Systemic Sclerosis | |
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| The SL Chicken Model for Human Autoimmune Vitiligo | |
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| Conclusions and Outlook | |
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| References | |
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| Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity | |
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| Abstract | |
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| Introduction | |
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| Phenotype of CD4[superscript +]CD25[superscript +] nTreg Cells | |
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| Factors Regulating the Expansion and Specificity of nTreg Cells | |
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| Innate and Adaptive Inflammatory Signals Dictating the Function of nTreg Cells | |
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| Growth Factor-Mediated Control of nTreg Cell Development, Function, and Homeostasis | |
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| Control of Autoimmune Responses by nTreg Cells | |
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| Summary and Conclusions | |
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| References | |
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| BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation | |
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| Abstract | |
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| Overview of BTLA and HVEM Ligand Discovery | |
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| Structural Characterization of BTLA Bound to HVEM | |
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| Viral Modulators of the HVEM-BTLA Pathway | |
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| Expression and Regulation of BTLA, LIGHT, and HVEM on T Cells and APCs | |
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| Mechanisms of the CD28 Family Inhibitory Receptors | |
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| Consequences of HVEM Ligation | |
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| BTLA and HVEM in Models of Disease | |
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| Conclusions | |
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| References | |
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| The Human T Cell Response to Melanoma Antigens | |
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| Abstract | |
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| Introduction | |
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| Melanoma Antigens | |
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| Measurement of Antigen-Specific T Cell Responses | |
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| Naturally Acquired Tumor Antigen-Specific T Cell Responses | |
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| Vaccine-Induced T Cell Responses | |
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| Regulation of Tumor Antigen-Specific T Cell Responses | |
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| Conclusions | |
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| References | |
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| Antigen Presentation and the Ubiquitin-Proteasome System in Host-Pathogen Interactions | |
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| Abstract | |
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| Host-Pathogen Interactions | |
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| Manipulation of the Host Response by Pathogens: Some General Considerations | |
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| Antigen Presentation | |
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| Class I MHC Antigen Presentation | |
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| Pathogen Recognition by CD8[superscript +] T Cells and NK Cells | |
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| Class II MHC Antigen Presentation | |
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| Ubiquitin-Proteasome System | |
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| The Ubiquitin Conjugation Cascade | |
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| Ubiquitin Ligases | |
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| Ubiquitin Chains and Ubiquitin-Like Modifiers (Ubls) | |
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| Deubiquitinating Enzymes | |
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| The Proteasome | |
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| ER Quality Control and Degradation | |
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| ERAD Substrate Recognition | |
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| ERAD E3 Ligases | |
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| Mammalian ERAD E3s | |
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| The Elusive Dislocon | |
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| Driving Dislocation and the Ub-Binding Route to the Proteasome | |
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| Peptide N-Glycanase | |
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| Viral Interference with Class I MHC Antigen Presentation | |
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| Human Cytomegalovirus | |
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| HCMV Interference with Class I MHC Antigen Presentation | |
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| Dislocation from the ER: HCMV US11 and US2 | |
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| Signal Peptide Peptidase Is Required for Dislocation from the ER | |
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| SPP and Generation of HLA-E Epitopes | |
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| SPP and Processing of the Hepatitis C Virus Core Protein | |
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| SPP and Calmodulin Signaling | |
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| SPP Peptide Peptidase and Development | |
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| SPP and ER Quality Control | |
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| Three Routes of Pathogen-Mediated ER Protein Disposal | |
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| Pathogen Interference with Class II MHC Antigen Presentation | |
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| Inhibition of Recognition at the Surface of the APC | |
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| Class II MHC Downregulation from the Surface of the APC | |
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| CD4 Downregulation from the Surface of the CD4[superscript +] T Cell | |
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| Pathogen Manipulation of the Ubiquitin-Proteasome System | |
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| Interference with Proteasomal Proteolysis | |
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| Control of Infection | |
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| Virus Budding | |
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| Bacterial Chromosome Integration | |
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| ISGylation and deISGylation | |
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| Control of Inflammation | |
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| Posttranscriptional Gene Silencing | |
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| Downregulation of Cell Surface Receptors by Pathogen-Encoded E3s | |
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| Programmed Cell Death in Plants | |
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| Cytokine Responses | |
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| Pathogen-Encoded DUBs | |
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| Conclusions and Future Directions | |
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| References | |
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| Index | |
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| Contents of Recent Volumes | |