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| Contributors | |
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| Preface | |
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| Neuroimmune Relationships in Perspective | |
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| Introduction | |
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| Innate and Acquired Immunity | |
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| The Neuroendocrine System and the Balance of the Immune System | |
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| Conclusions | |
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| Sympathetic Nervous System Interaction with the Immune System | |
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| Introduction | |
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| Anatomy and Physiology | |
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| Adrenergic Receptor Expression on Immune Cells | |
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| Effect of [beta subscript 2]AR Stimulation on CD4[superscript +] T Lymphocytes | |
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| Effect of [beta subscript 2] AR Stimulation on B Lymphocytes | |
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| Conclusion | |
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| References | |
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| Mechanisms by Which Cytokines Signal the Brain | |
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| Introduction | |
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| Interleukin-1 (IL-1) | |
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| Conclusions | |
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| References | |
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| Neuropeptides: Modulators of Immune Responses in Health and Disease | |
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| Introduction | |
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| CRH and Related Peptides | |
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| Pro-opiomelanocortin (POMC) Peptides | |
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| Opioid Peptides Other Than [beta]-Endorphin | |
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| Trophic Peptides | |
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| Other Immunoneuropeptides | |
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| Quantitative Analysis of Immunoneuropeptides by MACS | |
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| Conclusions | |
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| References | |
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| Brain-immune Interactions in Sleep | |
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| Sleep | |
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| Microbial Products and Cytokines: A Brief Overivew | |
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| Effects of Microbial Products and Cytokines on Sleep | |
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| Effect of Sleep-Wake Activity on Cytokines and the Immune System | |
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| Summary | |
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| References | |
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| Neuroendocrinology of Autoimmunity | |
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| Introduction | |
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| The Hypothalamic-Pituitary-Adrenal (HPA) Axis | |
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| The HPA Axis in Autoimmune Disease | |
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| Neurotransmitters in Disease | |
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| Summary | |
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| References | |
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| Systemic Stress-Induced Th2 Shift and Its Clinical Implications | |
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| Introduction | |
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| Th1/Th2 Paradigm: Role of Type 1 and Type 2 Cytokines | |
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| Stress Hormones and Th1/Th2 Balance | |
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| Clinical Implications | |
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| Conclusions | |
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| References | |
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| Neural Control of Salivary S-IgA Secretion | |
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| Introduction | |
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| Nerve-Mediated Increases in Salivary Secretion of S-IgA | |
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| Autonomimetic Stimulation of pIgR-Mediated IgA Transcytosis | |
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| Studies of Reflex IgA Secretion | |
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| Long-Term Influences of Nerves on S-IgA Secretion | |
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| Effects of Nerves on Plasma Cell Production of IgA | |
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| Conclusion | |
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| References | |
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| Stress and Secretory Immunity | |
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| Introduction | |
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| Saliva as a Model for Mucosal Secretory Defense | |
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| An Outline of Secretory Immunity | |
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| The Neurobiological Basis for Stress-Induced Changes in Salivary Secretory Immunity | |
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| Stress and Secretory IgA | |
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| Stress and Innate Secretory Immunity | |
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| Stress and Microbial Colonization Processes | |
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| Future Perspectives | |
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| References | |
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| Cytokines and Depression | |
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| Introduction | |
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| Depression and Immune System Dysregulation | |
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| Neuroendocrine Dysregulation | |
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| Relationship between Immune and Neuroendocrine System Changes | |
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| Effect of Cytokines on Mood | |
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| Role of Brain Monoamines | |
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| Conclusions | |
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| References | |
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| Immunity and Schizophrenia: Autoimmunity, Cytokines, and Immune Responses | |
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| Background | |
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| Autoimmune Diseases and Schizophrenia | |
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| T and B Lymphocytes in Schizophrenia | |
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| HLA Antigens in Schizophrenia | |
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| HPA Axis in Schizophrenia | |
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| Effects of Antipsychotic Medication | |
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| Treatment of Schizophrenia with Immunosuppressants | |
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| Vaccine Response | |
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| Th1/Th2 Imbalance in Schizophrenia | |
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| Summary | |
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| References | |
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| Cerebral Lateralization and the Immune System | |
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| Introduction | |
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| Opposite Effects of Left- and Right-Cortical Ablations on Immunity | |
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| Association between Behavioral Lateralization and Immune Reactivity | |
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| General Conclusion and Perspectives | |
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| References | |
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| Behavioral Conditioning of the Immune System | |
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| Introduction | |
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| Conditioned Immunosuppression Using Cyclosporin A | |
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| Conditioned Immunopotentiation | |
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| Antigen as the Unconditioned Stimulus | |
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| Human Studies | |
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| Conclusion | |
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| References | |
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| Psychological and Neuroendocrine Correlates of Disease Progression | |
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| Introduction | |
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| Psychological Correlates Associated with Disease Progression | |
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| Intervention Studies | |
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| Neuroendocrine and Immunological Correlates That Underpin Disease Progression | |
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| Neuroimmune Alterations Associated with Psychological Interventions | |
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| Other Explanatory Mechanisms in Disease Progression | |
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| References | |
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| The Role of Psychological Intervention in Modulating Aspects of Immune Function in Relation to Health and Well-Being | |
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| Introduction | |
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| Relaxation Training | |
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| Guided Imagery of the Immune System | |
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| Hypnosis and Immunity | |
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| Research Directions | |
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| References | |
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| Index | |
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| Contents of Recent Volumes | |