Signal Transduction

ISBN-10: 0122896327

ISBN-13: 9780122896323

Edition: N/A

List price: $78.95
30 day, 100% satisfaction guarantee

If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.

Learn more about our returns policy


Signal Transduction now in paperback, is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work. * Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms
what's this?
Rush Rewards U
Members Receive:
You have reached 400 XP and carrot coins. That is the daily max!
Study Briefs

Limited time offer: Get the first one free! (?)

All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.

Add to cart
Study Briefs
Periodic Table Online content $4.95 $1.99
Add to cart
Study Briefs
Medical Terminology Online content $4.95 $1.99
Add to cart
Study Briefs
Medical Math Online content $4.95 $1.99
Customers also bought

Book details

List price: $78.95
Publisher: Elsevier Science & Technology Books
Publication date: 10/15/2003
Binding: Paperback
Pages: 420
Size: 7.50" wide x 9.50" long x 0.75" tall
Weight: 2.640
Language: English

Prologue: Signal transduction, origins and personalities
Transduction, the word and its meaning: one dictionary, different points of view
Hormones, evolution and history
Hormones: a definition
Receptors and ligands
First messengers
Binding of ligands to receptors
Adrenaline (again)
[alpha]- and [beta]-adrenergic receptors
Acetylcholine receptors
Ion channel-linked receptors
The 7TM superfamily of G-protein linked receptors
Receptor-ligand interaction and receptor activation
Transmitting signals into cells
Intracellular 7TM receptor domains and signal transmission
Adrenaline (yet again)
GTP-binding proteins and signal transduction
Nucleotides as metabolic regulators
GTP-binding proteins, G-proteins or GTPases
Ras proteins
Essay: Activation of G-proteins without subunit dissociation
Effector enzymes coupled to GTP-binding proteins: Adenylyl cyclase and phospholipase C
Adenylyl cyclase
Phospholipase C
The regulation of visual transduction
Sensitivity of photoreceptors
Photoreceptor mechanisms
Adaptation: calcium acts as a negative regulator
Photo-excitation of rhodopsin
Switching off the mechanism
A note on phototransduction in invertebrates
Calcium and signal transduction
A new second messenger is discovered
Calcium and evolution
Distinguishing Ca[superscript 2+] and Mg[superscript 2+]
Free, bound and trapped Ca[superscript 2+]
Cytosol Ca[superscript 2+] is kept low
Detecting changes in cytosol Ca[superscript 2+]
Mechanisms that elevate cytosol Ca[superscript 2+] concentration
The pattern of cytosol Ca[superscript 2+] changes in single cells
Localization of intracellular second messengers
Calcium signalling
Calcium binding by proteins
Effects of elevated calcium
Paradigms of calcium signalling
Phosphorylation and dephosphorylation: Protein kinases A and C
Protein phosphorylation as a switch in cellular functioning
cAMP and the amplification of signals
Protein kinase A
Protein kinase A and the regulation of transcription
Protein kinase A and the activation of ERK
Actions of cAMP not mediated by PKA
Protein kinase C
The protein kinase C family
Structural domains and activation of protein kinase C
Multiple sources of DAG and other lipids to activate PKC
Differential localization of PKC isoforms
PKC anchoring proteins, STICKs, PICKs and RACKs
PKC and cell transformation
PKC and inflammation
Growth factors: Setting the framework
Viruses and tumours
The discovery of NGF ... and EGF
Platelet derived growth factor
Transforming growth factors
Problems with nomenclature
Essay: The cell cycle
Essay: Cancer and cell transformation
Signalling pathways operated by receptor protein tyrosine kinases
The tyrosine kinase family
Tyrosine kinase-containing receptors
Branching of the signalling pathway
A switch in receptor signalling: Activation of ERK by 7TM receptors
Signalling pathways operated by non-receptor protein tyrosine kinases
The non-receptor protein tyrosine kinase family
Interferons and their effects
Oncogenes, malignancy and signal transduction
Essay: Non-receptor protein tyrosine kinases and their activation
Phosphoinositide 3-kinases, protein kinase B and signalling through the insulin receptor
Insulin receptor signalling; it took some time to discover
PI 3-kinase
Insulin: The role of IRS, PI 3-kinase and PKB in the regulation of glycogen synthesis
Other processes mediated by the 3-phosphorylated inositol phospholipids
Multiple kinases and multiple phosphorylation sites, PDK1 as an integrator of multiple inputs
So, who did discover insulin?
Signal transduction to and from adhesion molecules
Adhesion molecules
Adhesion molecules and cell survival
Adhesion molecules and regulation of the cell cycle
Adhesion molecules as tumour suppressors
Essay: Apoptosis
Adhesion molecules and trafficking of leukocytes
Inflammation and its mediators
TNF[alpha] and regulation of adhesion molecule expression in endothelial cells
Signalling through receptor bound protein serine/threonine kinases
The TGF[beta] family of growth factors
Downstream signalling; Drosophila, Caenorhabditis and Smad
Protein dephosphorylation and protein phosphorylation
The importance of dephosphorylation
The role of PTPs in signal transduction
Negative regulation through dephosphorylation
Serine-threonine phosphatases
Classification of protein serine-threonine phosphatases
Protein domains and signal transduction
Structurally conserved protein modules
Domains that bind oligopeptide motifs
Domains that bind proteins and lipids
Polypeptide modules that bind Ca[superscript 2+]
Protein kinase domains
Free shipping on orders over $35*

*A minimum purchase of $35 is required. Shipping is provided via FedEx SmartPost® and FedEx Express Saver®. Average delivery time is 1 – 5 business days, but is not guaranteed in that timeframe. Also allow 1 - 2 days for processing. Free shipping is eligible only in the continental United States and excludes Hawaii, Alaska and Puerto Rico. FedEx service marks used by permission."Marketplace" orders are not eligible for free or discounted shipping.

Learn more about the TextbookRush Marketplace.