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Overview and history of DNA typing | |
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DNA biology review | |
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Sample collection, DNA extraction and DNA quantitation | |
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The polymerase chain reaction (DNA amplification) | |
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Commonly used short tandem repeat markers and commercial kits | |
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Biology of STRs : stutter products, non-template addition, microvariants, null alleles and mutation rates | |
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Forensic issues : degraded DNA, PCR inhibition, contamination, mixed samples and low copy number | |
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Single nucleotide polymorphisms and other bi-allelic markers | |
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Y chromosome DNA testing | |
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Mitochondrial DNA analysis | |
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Non-human DNA testing and microbial forensics | |
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DNA separation methods : slab gel and capillary electrophoresis | |
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DNA detection methods : fluorescent dyes and silver-staining | |
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Instrumentation for STR typing : ABI 310, ABI 3100, FMBIO systems | |
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STR genotyping issues | |
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Laboratory validation | |
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New technologies, automation, and expert systems | |
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Combined DNA index system (CODIS) and the use of DNA databases | |
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Basic genetic principles, statistics, and probability | |
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STR population database analyses | |
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Profile frequency estimates, likelihood ratios, and source attribution | |
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Approaches to statistical analysis of mixtures and degraded DNA | |
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Kinship and parentage testing | |
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Mass disaster DNA victim identification | |
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Reported STR alleles : sizes and sequences | |
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U.S. population data - STR allele frequencies | |
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Suppliers of DNA analysis equipment, products, OR services | |
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DNA advisory board quality assurance standards | |
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DAB recommendations on statistics | |
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NRC II recommendations | |
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Example DNA cases | |