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Antipsychotic Drugs and Their Side-Effects

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ISBN-10: 0120790351

ISBN-13: 9780120790357

Edition: 1993

Authors: Thomas R. E. Barnes, Peter Jenner

List price: $118.95
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Description:

In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for…    
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Book details

List price: $118.95
Copyright year: 1993
Publisher: Elsevier Science & Technology Books
Publication date: 1/6/1994
Binding: Hardcover
Pages: 287
Size: 9.50" wide x 6.50" long x 1.00" tall
Weight: 1.188
Language: English

Contributors
Series Preface
Neuroscience Editorial Advisory Board
Preface
The pharmacology of the phenothiazines, butyrophenones, thioxanthines and diphenylbutylpiperidinesp. 3
The pharmacology of clozapine-like atypical antipsychoticsp. 27
Pharmacology and clinical properties of selective dopamine antagonists with focus on substituted benzamidesp. 45
Pre- and postsynaptic D[subscript 1] to D[subscript 5] dopamine receptor mechanisms in relation to antipsychotic activityp. 65
Prediction of antipsychotic activityp. 87
Effects of neuroleptics on neuronal and synaptic structurep. 99
Brain imaging and antipsychotic drugsp. 111
Pharmacokinetics of antipsychotic drugsp. 127
The assessment of antipsychotic medication in clinical trialsp. 147
Indications for antipsychotic drugsp. 157
Acute treatmentp. 169
Maintenance antipsychotic medicationp. 183
Depot neurolepticsp. 205
The side-effects of antipsychotic drugs. I. CNS and neuromuscular effectsp. 213
The side-effects of antipsychotic drugs. II. Effects on other physiological systemsp. 249
Indexp. 277
Table of Contents provided by Blackwell. All Rights Reserved.