Drug-Drug Interactions: Scientific and Regulatory Perspectives

Name: Drug-Drug Interactions: Scientific and Regulatory Perspectives
Price: 256.39 USD
Availability: InStock
ISBN: 9780120329441

ISBN-10: 0120329441

ISBN-13: 9780120329441

Edition: 1997

Authors: J. Thomas August, Ferid Murad, M. W. Anders, Joseph T. Coyle, Albert Li

List price: $270.00

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Description:

DrugDrug Interactions is a comprehensive review of the scientific and regulatory perspectives of drugdrug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drugdrug interactions, the prediction of drugdrug interaction potential of new drugs, and the avoidance of clinically significant drugdrug interaction in patients.

Book details

List price: $270.00
Copyright year: 1997
Publisher: Elsevier Science & Technology
Publication date: 11/6/1997
Binding: Hardcover
Pages: 304
Size: 5.94" wide x 9.00" long x 0.75" tall
Weight: 1.364
Language: English



Foreword



Preface



Overview: Scientific Basis of Pharmacokinetic Drug-Drug Interactions



Role of Cytochrome P450 Enzymes in Drug-Drug Interactions



The Liver as a Target for Chemical-Chemical Interactions



Applications of Human Liver Microsomes in Metabolism-Based Drug-Drug Interactions



Applications of Human Hepatocytes as an Experimental System for the Evaluation of Pharmacokinetic Drug-Drug Interactions



Liver Slices as a Model in Drug Metabolism and Drug-Drug Interactions



The Use of cDNA Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions



Pharmacokinetics of Drug Interactions



Experimental Models for Evaluating Enzyme Induction Potential of New Drug Candidates in Animals and Man and a Strategy for Their Use



Metabolic Drug-Drug Interactions: Perspective from U.S. FDA Medical and Clinical Pharmacology Reviewers



Drug Interactions: Perspectives of the Canadian Directorate