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| Contributors | |
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| Preface | |
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| Acknowledgments | |
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| Introduction | |
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| General Considerations | |
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| The Epidemiology and Burden of Skin Disease | |
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| Evidence-Based Dermatology | |
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| Global Health in Dermatology | |
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| Public Health in Dermatology | |
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| Approach to Dermatologic Diagnosis | |
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| Structure of Skin Lesions and Fundamentals of Clinical Diagnosis | |
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| Basic Pathologic Reactions of the Skin | |
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| Overview of Biology, Development, and Structure of Skin | |
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| Development and Structure of Skin | |
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| Genetics in Relation to the Skin | |
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| Racial Considerations: Skin of Color | |
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| Disorders Presenting in Skin and Mucous Membranes | |
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| Inflammatory Disorders Based on T-Cell Reactivity and Dysregulation | |
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| Innate and Adaptive Immunity for the Skin | |
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| Cytokines | |
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| Chemokines | |
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| Allergic Contact Dermatitis | |
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| Atopic Dermatitis (Atopic Eczema) | |
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| Nummular Eczema and Lichen Simplex Chronicus/Prurigo Nodularis | |
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| Vesicular Palmoplantar Eczema | |
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| Autosensitization Dermatitis | |
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| Psoriasis | |
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| Psoriatic Arthritis | |
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| Reactive Arthritis | |
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| Pustular Eruptions of Palms and Soles | |
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| Seborrheic Dermatitis | |
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| Exfoliative Dermatitis | |
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| Pityriasis Rubra Pilaris | |
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| Parapsoriasis and Pityriasis Lichenoides | |
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| Lichen Planus | |
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| Lichen Nitidus | |
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| Graft-versus-Host Disease | |
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| Skin Disease in Acute and Chronic Immunosuppression | |
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| Inflammatory Diseases Based on Neutrophilsand Eosinophils | |
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| Regulation of the Production and Activation of Neutrophils | |
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| Regulation of the Production and Activation of Eosinophils | |
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| Acute Febrile Neutrophilic Dermatosis (Sweet Syndrome) | |
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| Pyoderma Gangrenosum | |
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| Granuloma Faciale | |
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| Sub-Corneal Pustular Dermatosis (Sneddon-Wilkinson Disease) | |
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| Eosinophils in Cutaneous Diseases | |
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| Inflammatory Diseases Based on Abnormal Humoral Reactivity and Other Inflammatory Diseases | |
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| Humoral Immunity and Complement | |
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| Urticaria and Angioedema | |
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| Erythema Multiforme | |
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| Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) | |
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| Cutaneous Reactions to Drugs | |
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| Pityriasis Rosea | |
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| Erythema Annulare Centrifugum and Other Figurate Erythemas | |
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| Granuloma Annulare | |
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| Disorders of Epidermal Differentiation and Keratinization | |
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| Epidermal Stem Cells | |
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| Epidermal Growth and Differentiation | |
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| Skin as an Organ of Protection | |
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| Irritant Contact Dermatitis | |
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| The Ichthyoses | |
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| Inherited Keratodermas of Palms and Soles | |
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| Acantholytic Disorders of the Skin | |
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| Porokeratosis | |
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| Disorders of Epidermal and Dermal-Epidermal Cohesion and Vesicular and Bullous Disorders | |
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| Epidermal and Epidermal-Dermal Abrasion | |
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| Pemphigus | |
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| Paraneoplastic Pemphigus | |
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| Bullous Pemphigoid | |
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| Cicatricial Pemphigoid | |
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| Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood | |
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| Pemphigoid Gestationis (Herpes Gestationis) | |
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| Epidermolysis Bullosa Acquisita | |
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| Dermatitis Herpetiformis | |
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| Inherited Epidermolysis Bullosa | |
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| Disorders of the Dermal Connective Tissue | |
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| Collagens, Elastic Fibers, and Other Extracellular Matrix Proteins of the Dermis | |
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| Morphea | |
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| Lichen Sclerosus | |
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| Dermal Hypertrophies and Benign Fibroblastic/Myofibroblastic Tumors | |
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| Anetoderma and Other Atrophic Disorders of the Skin | |
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| Ainhum and Pseudoainhum | |
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| Acquired Perforating Disorders | |
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| Disorders of Subcutaneous Tissue | |
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| Panniculitis | |
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| Lipodystrophy | |
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| Disorders of Melanocytes | |
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| Biology of Melanocytes | |
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| Albinism and Other Genetic Disorders of Pigmentation | |
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| Vitiligo | |
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| Hypomelanoses and Hypermelanoses | |
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| Disorders of the Oral and Genital Integument | |
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| Biology and Pathology of the Oral Cavity | |
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| Diseases and Disorders of the Male Genitalia | |
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| Diseases and Disorders of the Female Genitalia | |
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| Disorders of the Skin Appendages | |
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| Disorders of the Sebaceous Glands | |
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| Biology of Sebaceous Glands | |
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| Acne Vulgaris and Acneiform Eruptions | |
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| Rosacea | |
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| Perioral Dermatitis | |
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| Disorders of the Eccrine and Apocrine Glands | |
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| Biology of Eccrine, Apocrine, and Apoeccrine Sweat Glands | |
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| Disorders of the Eccrine Sweat Glands and Sweating | |
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| Disorders of the Apocrine Sweat Glands | |
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| Disorders of the Hair and Nails | |
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| Biology of Hair Follicles | |
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| Keratosis Pilaris and Other Inflammatory Follicular Keratotic Syndromes | |
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| Hair Growth Disorders | |
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| Biology of Nails and Nail Disorders | |
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| Disorders Due to the Environment | |
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| Disorders Due to Ultraviolet Radiation | |
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| Fundamentals of Cutaneous Photobiology and Photoimmunology | |
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| Abnormal Responses to Ultraviolet Radiation: Idiopathic, Probably Immunologic, and Photoexacerbated | |
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| Abnormal Responses to Ultraviolet Radiation: Photosensitivity Induced by Exogenous Agents | |
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| Skin Changes Due to Other Physical and Chemical Factors | |
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| Thermoregulation | |
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| Cold Injuries | |
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| Thermal Injuries | |
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| Skin Problems in Amputees | |
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| Skin Problems in Ostomates | |
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| Corns and Calluses | |
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| Sports Dermatology | |
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| Decubitus (Pressure) Ulcers | |
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| Body Art | |
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| Neurocutaneous and Psychocutaneous Aspects of Skin Disease | |
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| Neurocutaneous and Psychocutaneous Skin Disease | |
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| Neurobiology of the Skin | |
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| Pathophysiology and Clinical Aspects of Pruritus | |
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| Psychocutaneous Skin Disease | |
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| Cutaneous Manifestations of Drug Abuse | |
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| Skin Signs of Physical Abuse | |
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| Skin Changes Across the Life Span | |
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| From Birth to Old Age | |
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| Neonatal, Pediatric, and Adolescent Dermatology | |
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| Skin Changes and Diseases in Pregnancy | |
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| Aging of Skin | |
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| Neoplasia | |
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| Carcinogenesis | |
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| Genome Instability, DNA Repair, and Cancer | |
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| Chemical Carcinogenesis | |
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| Ultraviolet Radiation Carcinogenesis | |
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| Epidermal and Appendageal Tumors | |
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| Epithelial Precancerous Lesions | |
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| Squamous Cell Carcinoma | |
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| Basal Cell Carcinoma | |
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| Basal Cell Nevus Syndrome | |
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| Keratoacanthoma | |
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| Benign Epithelial Tumors, Hamartomas, and Hyperplasias | |
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| Appendage Tumors and Hamartomas of the Skin | |
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| Merkel Cell Carcinoma | |
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| Mammary and Extramammary Paget Disease | |
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| Melanocytic Tumors | |
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| Benign Neoplasias and Hyperplasias of Melanocytes | |
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| Atypical (Dysplastic) Melanocytic Nevi | |
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| Cutaneous Melanoma | |
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| Tumors and Hyperplasias of the Dermis and Subcutaneous Fat | |
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| Malignant Fibrous, Fibrohistiocytic, and Histiocytic Tumors of the Dermis | |
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| Vascular Tumors | |
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| Neoplasias and Hyperplasias of Muscular and Neural Origin | |
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| Kaposi Sarcoma | |
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| Neoplasms of Subcutaneous Fat | |
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| the Skin in Systemic Disease | |
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| Skin in Nutritional, Metabolic, and Heritable Disease | |
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| Cutaneous Features of Nutritional Disease | |
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| Cutaneous Changes in Errors of Amino Acid Metabolism | |
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| The Porphyrias | |
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| Amyloidosis and the Skin | |
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| The Systemic Monogenic Autoinflammatory Diseases | |
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| Xanthomatoses and Lipoprotein Disorders | |
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| Fabry Disease | |
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| Lipoid Proteinosis and Heritable Disorders of Connective Tissue | |
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| Cutaneous Mineralization and Ossification | |
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| Hereditary Disorders of Genome Instability and DNA Repair | |
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| Tuberous Sclerosis Complex | |
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| The Neurofibromatoses | |
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| Ectodermal Dysplasias | |
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| Genetic Immunodeficiency Diseases | |
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| Skin Manifestations of Bone Marrow or Blood Chemistry Disorders | |
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| Hematologic Diseases | |
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| Cutaneous Lymphoma | |
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| Inflammatory Diseases That Simulate Lymphomas: Cutaneous Pseudolymphomas | |
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| Cutaneous Langerhans Cell Histiocytosis | |
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| Non-Langerhans Cell Histiocytosis | |
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| Mastocytosis | |
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| Skin Manifestations of Internal Organ Disorders | |
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| The Skin and Disorders of the Alimentary Trace, the Hepatobiliary System, Kidney and Cardiopulmonary System | |
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| Diabetes Mellitus and Other Endocrine Diseases | |
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| Sarcoidosis | |
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| Cutaneous Manifestations of Internal Malignant Disease | |
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| The Skin in Vascular and Connective Tissue and Other Autoimmune Disorders | |
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| Mechanisms of Autoimmune Disease | |
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| Lupus Erythematosus | |
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| Dermatomyositis | |
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| Scleroderma (Systematic Sclerosis) | |
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| Scleredema and Scleromyxedema | |
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| Relapsing Polychondritis | |
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| Rheumatoid Arthritis, Rheumatic Fever, and Gout | |
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| Sjgren Syndrome | |
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| The Skin in Inflammatory and Other Vascular Disorders | |
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| Endothelium in Inflammation and Angiogenesis | |
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| Cutaneous Necrotizing Venulitis | |
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| Systemic Necrotizing Arteritis | |
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| Erythema Elevatum Diutinum | |
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| Adamantiades-Behet Disease | |
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| Kawasaki Disease | |
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| Pigmented Purpuric Dermatoses | |
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| Cryoglobulinemia and Cryofibrinogenemia | |
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| Raynaud Phenomenon | |
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| Malignant Atrophic Papulosis (Degos Disease) | |
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| Vascular Malformations | |
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| Cutaneous Changes in Peripheral Vascular Arterial Disease | |
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| Cutaneous Changes in Venous and Lymphatic Insufficiency | |
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| Disease Due To Microbial Agents, Infestations, Bites, and Stings | |
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| Bacterial Disease | |
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| General Considerations of Bacterial Diseases | |
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| Superficial Cutaneous Infections and Pyodermas | |
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| Gram-Positive Infections Associated with Toxin Production | |
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| Non-Necrotizing Infections of the Dermis and Subcutaneous Fat: Cellulitis and Erysipelas | |
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| Necrotizing Soft Tissue Infections: Necrotizing Fasciitis, Gangrenous Cellulitis, and Myonecrosis | |
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| Gram-Negative Coccal and Bacillary Infections | |
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| The Skin in Infective Endocarditis, Sepsis, Septic Shock, and Disseminated Intravascular Coagulation | |
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| Bartonellosis | |
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| Miscellaneous Bacterial Infections with Cutaneous Manifestations | |
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| Tuberculosis and Infections with Atypical Mycobacteria | |
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| Actinomyosis, Nocardiosis, and Actinomycetoma | |
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| Leprosy | |
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| Lyme Borreliosis | |
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| Fungal Diseases | |
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| Superficial Fungal Infection | |
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| Yeast Infections: Candidiasis, Tinea (Pityriasis) Versicolor and Malassezia (Pityrosporum) Folliculitis | |
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| Deep Fungal Infections | |
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| Viral and Rickettsial Diseases | |
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| Viral Diseases: General Considerations | |
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| Exanthematous Viral Diseases | |
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| Herpes Simplex | |
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| Varicella and Herpes Zoster | |
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| Poxvirus Infections | |
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| Warts | |
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| Human Retroviral Disease: Human T-Lymphotropic Viruses | |
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| Cutaneous Manifestations of Human Immunodeficiency Virus | |
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| The Rickettsioses, Ehrlichioses, and Anaplasmoses | |
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| Sexually Transmitted Diseases | |
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| Syphilis | |
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| Endemic (Non-venereal) Treponematoses | |
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| Chancroid | |
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| Lymphogranuloma Venereum | |
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| Granuloma Inguinale | |
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| Gonorrhea and Other Mucosal-Based Venereal Diseases | |
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| Infestations, Bites, and Stings | |
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| Leishmaniasis and Other Protozoan Infections | |
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| Helminthic Infections | |
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| Scabies, Other Mites, and Pediculosis | |
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| Bites and Stings of Terrestrial and Aquatic Life | |
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| Arthropod Bites and Stings | |
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| Occupational Skin Diseases and Skin Diseases Due to Biologic Warfare | |
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| Occupational Skin Diseases | |
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| Occupational Skin Disease due to Irritants and Allergens | |
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| Occupational Noneczematous Skin Diseases Due to Biologic, Physical, and Chemical Agents: Introduction | |
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| The Skin in Bioterrorism and Biologic Warfare | |
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| Cutaneous Manifestations of Biologic, Chemical, and Radiologic Terrorism Attacks | |
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| Therapeutics | |
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| Topical Therapy | |
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| Principles of Topical Therapy | |
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| Pharmacokinetics and Topical Applications of Drugs | |
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| Topical Cortocosteroids | |
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| Topical Retinoids | |
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| Topical Antibiotics | |
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| Topical Antifungal Agents | |
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| Topical and Intralesional Cytotoxic Agents | |
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| Topical Immunomodulators | |
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| Other Topical Medications | |
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| Photoprotection | |
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| Systemic Therapy | |
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| Systemic Glucocorticoids | |
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| Dapsone | |
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| Aminoquinolines | |
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| Cytotoxic and Antimetabolic Agents | |
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| Retinoids | |
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| Antihistamines | |
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| Antibiotics | |
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| Antiviral Drugs | |
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| Oral Antifungal Agents | |
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| Mycophenolate Mofetil, Cyclosporine, and Related Immunosuppressive Therapies | |
| |
| |
| |
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| Immunobiologicals, Cytokines, and Growth Factors in Dermatology | |
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| |
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| Anti-angiogenic Agents | |
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| |
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| Drug Interactions | |
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| |
| Physical Treatments | |
| |
| |
| |
| Phototherapy | |
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| |
| |
| |
| Photochemotherapy and Photodynamic Therapy | |
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| |
| |
| |
| Lasers and Flash Lamps in Dermatology | |
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| |
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| |
| Radiotherapy | |
| |
| |
| |
| |
| Complementary and Alternative Dermatology | |
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| |
| |
| Complementary and Alternative Medicine in Dermatology | |
| |
| |
| |
| |
| Surgery in Dermatology | |
| |
| |
| |
| Dermatologic Surgery: Introduction to Anatomy and Approach | |
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| |
| |
| |
| Excisional Surgery and Repair, Flaps, and Grafts | |
| |
| |
| |
| |
| Mohs Micrographic Surgery | |
| |
| |
| |
| |
| Nail Surgery | |
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| |
| |
| |
| Cryosurgery and Electrosurgery | |
| |
| |
| |
| |
| Surgical Complications | |
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| |
| |
| |
| Wound Repair: Mechanisms and Practical Considerations | |
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| |
| |
| |
| Treatment for Varicose and Telangiectatic Leg Veins | |
| |
| |
| |
| |
| Cosmetic Dermatology | |
| |
| |
| |
| Cosmetics and Skin Care in Dermatology | |
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| |
| |
| |
| Skin Resurfacing: Ablative Lasers, Chemical Peels, and Dermabrasion | |
| |
| |
| |
| |
| Cosmetic Applications of Non-Ablative Lasers and Other Light Devices | |
| |
| |
| |
| |
| Liposuction Using Tumescent Local Anesthesia | |
| |
| |
| |
| |
| Soft Tissue Augmentation | |
| |
| |
| |
| |
| Botulinum Toxin | |
| |
| |
| |
| |
| Hair Transplantation and Alopecia Reduction | |
| |
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| Index | |