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Greenspan's Basic and Clinical Endocrinology

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ISBN-10: 0071440119

ISBN-13: 9780071440110

Edition: 8th 2007 (Revised)

Authors: David G. Gardner, Dolores Shoback

List price: $68.95
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This book reviews the pathophysiology, diagnosis and treatment of endocrine diseases, emphasising molecular endocrinology and new diagnostic and therapeutic methods.
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Book details

List price: $68.95
Edition: 8th
Copyright year: 2007
Publisher: McGraw-Hill Medical Publishing Division
Publication date: 1/19/2007
Binding: Paperback
Pages: 960
Size: 7.50" wide x 9.25" long x 1.50" tall
Weight: 3.278

Author Profiles David Gardner, MD Director, The Diabetes Center Professor of Medicine Chief, Division of Endocrinology UCSF School of Medicine San Francisco, CaliforniaDolores Shoback, MD Professor in Residence UCSF School of Medicine Staff Physician Division of Endocrinology VA Medical Center San Francisco, California

Introduction to Endocrinology
The Endocrine System
Hormones: Endocrine, Paracrine, Autocrine, Juxtacrine, & Intracrine Actions
Endocrine Organs
Target Organs
Hormone Receptors
Chemical Composition of Hormones
Relationships between Hormones & Other Signaling Molecules
Neurotransmitters & Hormones
Vitamins & Hormones
Eicosanoids: Prostaglandins & Related Compounds
Oncogenes & Hormones
The Immune System & Hormones
Modulation of Hormone Levels
Regulation of Hormone Production
Molecular Mechanisms Regulating Hormone Release
Hormone Transport in the Circulation
Transport of Hormones across the Membrane
Metabolism & Elimination of Hormones
Mechanisms of Hormone Action
Hormone Receptors
Hormone Binding
Hormone Effects on Receptor Activity
Classes of Hormone Action
Classification of Hormone Action by Receptor Type
Classification of Hormone Action by Ligand Type
Regulation of Hormone Responsiveness
Regulation of Receptor Levels & Activities
Hormone Responsiveness Is Regulated by Postreceptor Influences
Combinatorial Interactions Influence Hormone Signaling in Different Ways
Selective Modulation
Evolution of the Endocrine System
The Origins of Regulatory Chemicals & the Metabolic Code
Evolution of Hormones & Receptors
Evolution of Multiple Hormone Response Systems
Evolution of Endocrine Glands
Integrative Networks
Endocrine & Nervous System Relationships: Neuroendocrinology
Actions of Hormones
Fetal Development
Cell Growth & Cancer
Intermediary Metabolism
Mineral & Water Metabolism
Cardiovascular & Renal Function
Skeletal Function
Reproductive Function
Immune System
Central Nervous System
Recent Advances in Technology & Endocrinology
Sequencing the Human Genome
Genomics & Patterns of Transcription
Manipulating the Genome
RNA Interference (RNAi)
Stem Cells
Molecular Basis of Genetic Endocrine Disease
Disorders of the Endocrine System
Endocrine Hypofunction
Endocrine Hyperfunction
Defects in Sensitivity to Hormones
Syndromes of Hormone Excess Due to Exogenous Hormone
Nonendocrine Problems Associated with Endocrine Disease
Approach to the Patient with Endocrine Disease
History & Physical Examination
Laboratory Studies
Screening for Endocrine Diseases
Treatment of Endocrine Diseases
Uses of Hormones & Selective Modulators in Therapy of Nonendocrine Disease
Mechanisms of Hormone Action
Neurotransmitter & Peptide Hormone Receptors
G Protein-Coupled Receptors
G Protein Transducers
Disorders of G Proteins and G Protein-Coupled Receptors
Growth Factor Receptors
Cytokine Receptors
Guanylyl Cyclase-Linked Receptors
Nuclear Action of Peptide Hormones
Nuclear Receptors
Steroid Receptor Family
Thyroid Receptor Family
Nongenomic Effects of the Steroid Hormones
Steroid & Thyroid Hormone Receptor Resistance Syndromes
Endocrine Autoimmunity
Basic Immune Components & Mechanisms
Immune Recognition & Response
Autoimmunity Is Multifactorial
Genetic Factors in Autoimmunity
Environmental Factors in Autoimmunity
Single Gland Autoimmune Syndromes
Autoimmune Aspects of Thyroid Disease
Autoimmune Aspects of Type 1 Diabetes
Autoimmune Aspects of Other Endocrinopathies
Autoimmune Polyglandular Syndromes
Autoimmune Polyglandular Syndrome I (APS-I)
Autoimmune Polyglandular Syndrome II (APS-II)
Management of Autoimmune Polyglandular Syndromes
Poems Syndrome (Osteosclerotic Myeloma)
Evidence-Based Endocrinology & Clinical Epidemiology
Clinical Epidemiology
Diagnostic Testing: Test Characteristics
An Approach to Diagnosis in Practice
Clinical Epidemiologic Principles Applied to Treatment Decisions
Decision Analysis
Other Aspects of Clinical Epidemiology
Evidence-Based Endocrinology
Translation of the Clinical Problem into Answerable Questions
Finding the Best Evidence
Appraising the Evidence for Its Validity & Usefulness
Applying the Results in Practice & Evaluating Performance
Hypothalamus & Pituitary Gland
Hypothalamic Hormones
Anterior Pituitary Hormones
Adrenocorticotropic Hormone & Related Peptides
Growth Hormone
Gonadotropins: Luteinizing Hormone & Follicle-Stimulating Hormone
Endocrinologic Evaluation of the Hypothalamic-Pituitary Axis
Evaluation of Adrenocorticotropic Hormone (ACTH)
Evaluation of Growth Hormone (GH)
Evaluation of Prolactin (PRL)
Evaluation of Thyroid-Stimulating Hormone (TSH)
Evaluation of LH & FSH
Problems in Evaluation of the Hypothalamic-Pituitary Axis
Effects of Pharmacologic Agents on Hypothalamic-Pituitary Function
Endocrine Tests of Hypothalamic-Pituitary Function
Neuroradiologic Evaluation
Pituitary & Hypothalamic Disorders
Empty Sella Syndrome
Hypothalamic Dysfunction
Pituitary Adenomas
Posterior Pituitary (Neurohypophysis)
Review of Normal Anatomy & Physiology
Vasopressin Insufficiency: Diabetes Insipidus
Excess Vasopressin: Syndrome of Inappropriate Antidiuretic Hormone (SIADH)
Normal Growth
Intrauterine Growth
The Placenta
Classic Hormones of Growth & Fetal Growth
Growth Factors & Oncogenes in Fetal Growth
Insulin-Like Growth Factors, Receptors, & Binding Proteins
Epidermal Growth Factor
Fetal Origins of Adult Disease
Postnatal Growth
Measurement of Growth
Skeletal (Bone) Age
Disorders of Growth
Short Stature Due to Nonendocrine Causes
Short Stature Due to Endocrine Disorders
Diagnosis of Short Stature
Tall Stature Due to Nonendocrine Causes
Tall Stature Due to Endocrine Disorders
The Thyroid Gland
Embryology, Anatomy, & Histology
Structure & Synthesis of Thyroid Hormones
Iodine Metabolism
Thyroid Hormone Synthesis & Secretion
Abnormalities in Thyroid Hormone Synthesis & Release
Metabolism of Thyroid Hormones
Control of Thyroid Function & Hormone Action
Physiologic Changes in Thyroid Function
Thyroid Autoimmunity
Tests of Thyroid Function
Tests of Thyroid Hormones in Blood
Assessment of Thyroid Iodine Metabolism & Biosynthetic Activity
Thyroid Imaging
Thyroid Ultrasonography & Other Imaging Techniques
Thyroid Biopsy
Test of Peripheral Thyroid Hormone Actions
Measurement of Thyroid Autoantibodies
Disorders of the Thyroid
Hyperthyroidism & Thyrotoxicosis
Thyroid Hormone Resistance Syndromes
Nontoxic Goiter
Effects of Ionizing Radiation on the Thyroid Gland
Thyroid Nodules & Thyroid Cancer
Metabolic Bone Disease
Cellular & Extracellular Calcium Metabolism
Parathyroid Hormone
Vitamin D
How Vitamin D & PTH Control Mineral Homeostasis
Medullary Carcinoma of the Thyroid (MCT)
Disorders Causing Hypercalcemia
Treatment of Hypercalcemia
Causes of Hypocalcemia
Treatment of Hypocalcemia
Bone Anatomy & Remodeling
Functions of Bone
Structure of Bone
Bone Remodeling
Treatment of Osteoporosis
Glucocorticoid-Induced Osteoporosis
Osteomalacia & Rickets
Nephrotic Syndrome
Hepatic Osteodystrophy
Drug-Induced Osteomalacia
Hypophosphatemic Disorders
Calcium Deficiency
Primary Disorders of the Bone Matrix
Inhibitors of Mineralization
Paget's Disease of Bone (Osteitis Deformans)
Renal Osteodystrophy
Glucocorticoids & Adrenal Androgens
Embryology & Anatomy
Biosynthesis of Cortisol & Adrenal Androgens
Circulation of Cortisol & Adrenal Androgens
Metabolism of Cortisol & Adrenal Androgens
Biologic Effects of Adrenal Steroids
Adrenal Androgens
Laboratory Evaluation
Disorders of Adrenocortical Insufficiency
Primary Adrenocortical Insufficiency (Addison's Disease)
Secondary Adrenocortical Insufficiency
Diagnosis of Adrenocortical Insufficiency
Treatment of Adrenocortical Insufficiency
Prognosis of Adrenocortical Insufficiency
Cushing's Syndrome
Hirsutism & Virilism
Incidental Adrenal Mass
Glucocorticoid Therapy for Nonendocrine Disorders
Endocrine Hypertension
Hypertension of Adrenal Origin
Synthesis, Metabolism, & Action of Mineralocorticoid Hormones
Pathogenesis of Mineralocorticoid Hypertension
Aldosterone & the Heart
Primary Aldosteronism
Syndromes Due to Excess Deoxycorticosterone Production
Cushing's Syndrome
Type II Pseudohypoaldosteronism (Arnold-Healy-Gordon Syndrome)
Hypertension of Renal Origin
The Renin-Angiotensin System
The Renin-Angiotensin System & Hypertension
Other Hormone Systems & Hypertension
Natriuretic Peptides
Nitric Oxide
Kallikrein-Kinin System
Other Hormones & Autacoids
Sympathetic Nervous System
Adrenal Medulla & Paraganglia
Hormones of the Adrenal Medulla
Other Hormones Secreted by the Adrenal Medulla
Disorders of Adrenal Medullary Function
Adrenal Medullary Hypofunction (Epinephrine Deficiency)
Adrenal Medullary Hyperfunction
Anatomy & Structure-Function Relationships
Accessory Structures
Physiology of the Male Reproductive System
Gonadal Steroids
Control of Testicular Function
Evaluation of Male Gonadal Function
Clinical Evaluation
Laboratory Tests of Testicular Function
Pharmacology of Drugs Used to Treat Male Gonadal Disorders
Gonadotropin-Releasing Hormone
Clinical Male Gonadal Disorders
Klinefelter's Syndrome (XXY Seminiferous Tubule Dysgenesis)
Bilateral Anorchia (Vanishing Testes Syndrome)
Leydig Cell Aplasia
Noonan's Syndrome (Male Turner's Syndrome)
Myotonic Dystrophy
Adult Seminiferous Tubule Failure
Adult Leydig Cell Failure (Andropause)
Male Infertility
Erectile Dysfunction (Impotence)
Testicular Tumors
Female Reproductive Endocrinology & Infertility
Embryology & Anatomy
Ovarian Steroidogenesis
Physiology of Folliculogenesis & the Menstrual Cycle
Menstrual Disturbances
Hypothalamic Amenorrhea
Pituitary Amenorrhea
Ovarian Amenorrhea
Outflow Tract Disorders
Oocyte Depletion
Endocrine System Changes with Aging
Menopausal Consequences
Diagnosis of Infertility
Management of the Infertile Couple
Oral Contraceptives
Contraception: Long-Acting Contraceptives
Emergency Contraception
Disorders of Sexual Determination & Differentiation
Normal Sex Differentiation
Testicular & Ovarian Differentiation
Psychosexual Differentiation
Atypical Sex Differentiation
Klinefelter's Syndrome and Its Variants: Seminiferous Tubule Dysgenesis
Syndrome of Gonadal Dysgenesis: Turner's Syndrome & Its Variants
Individuals with Both Ovarian and Testicular Tissue (True Hermaphroditism)
Female Pseudohermaphroditism
P450 Aromatase Deficiency
Maternal Androgens & Progestogens
Male Pseudohermaphroditism
Unclassified Forms of Abnormal Sexual Development in Males
Unclassified Forms of Abnormal Sexual Development in Females
Management of Patients with Intersex Problems
Physiology of Puberty
Delayed Puberty or Absent Puberty (Sexual Infantilism)
Precocious Puberty (Sexual Precocity)
The Endocrinology of Pregnancy
Conception & Implantation
Fetal-Placental-Decidual Unit
Polypeptide Hormones
Steroid Hormones
Maternal Adaptation to Pregnancy
Fetal Endocrinology
Endocrine Control of Parturition
Endocrinology of the Puerperium
Endocrine Disorders & Pregnancy Pituitary Disorders
Pregnancy & Breast Cancer
Hypertensive Disorders of Pregnancy
Hyperthyroidism in Pregnancy
Hypothyroidism in Pregnancy
Pancreatic Hormones & Diabetes Mellitus
The Endocrine Pancreas
Anatomy & Histology
Hormones of the Endocrine Pancreas
Diabetes Mellitus
Diabetes Mellitus
Other Specific Types of Diabetes
Clinical Features of Diabetes Mellitus
Blood Glucose Testing
Serum Ketone Determinations
Glycated Hemoglobin Assays
Lipoproteins in Diabetes
Oral Glucose Tolerance Test
Insulin Levels
Intravenous Glucose Tolerance Test
Agents for the Treatment of Hyperglycemia
Steps in the Management of the Diabetic Patient
Specific Chronic Complications of Diabetes Mellitus
Diabetic Patients Regulated by Diet Alone
Diabetic Patients Taking Oral Hypoglycemic Agents
Diabetic Patients Taking Insulin
Hypoglycemic Disorders
Pathophysiology of the Counterregulatory Response to Neuroglycopenia
Classification of Hypoglycemic Disorders
Clinical Presentation of Hypoglycemia
Specific Hypoglycemic Disorders
Symptomatic Fasting Hypoglycemia with Hyperinsulinism
Symptomatic Fasting Hypoglycemia without Hyperinsulinism
Nonfasting Hypoglycemia (Reactive Hypoglycemia)
Congenital Hyperinsulinism
Disorders of Lipoprotein Metabolism
Overview of Lipid Transport
Differentiation of Disorders of Lipoprotein Metabolism
Clinical Descriptions of Primary & Secondary Disorders of Lipoprotein Metabolism
Primary Hypertriglyceridemia
Secondary Hypertriglyceridemia
Familial Hypercholesterolemia
Familial Combined Hyperlipidemia
Lp(a) Hyperlipoproteinemia
Familial Ligand-Defective Apo B
Cholesterol 7-[alpha]-Hydroxylase Deficiency
Immunoglobulin Disorders
Anorexia Nervosa
Primary Hypolipidemia Due to Deficiency of High-Density Lipoproteins
Primary Hypolipidemia Due to Deficiency of Apo B-Containing Lipoproteins
The Lipodystrophies
Rare Disorders
Treatment of Hyperlipidemia
Bile Acid Sequestrants
Niacin (Nicotinic Acid)
Fibric Acid Derivatives
HMG-CoA Reductase Inhibitors
Cholesterol Absorption Inhibitors
Combined Drug Therapy
Obesity & Overweight
Clarification of Uncertainties Regarding the Pathogenesis of Obesity
Survey of Treatment Approaches & Their Efficacy
Diet & Exercise
Surgical Treatment of Obesity
Pharmacologic Therapies
Other Conditions Affected by Treatment of Obesity or Overweight
Type 2 Diabetes Mellitus
Polycystic Ovarian Syndrome
Sleep Apnea
Osteoarthritis & Other Weight-Sensitive States
A Systematic Approach to the Treatment of Obesity
Humoral Manifestations of Malignancy
Ectopic Hormone & Receptor Syndromes
Hypercalcemia of Malignancy
Ectopic Cushing's Syndrome
Syndrome of Inappropriate Anridiuretic Hormone Secretion
Non-Islet Cell Tumors & Hypoglycemia
Other Hormones Secreted by Tumors
Oncogenic Osteomalacia
Gut Hormones
Multiple Endocrine Neoplasia
Multiple Endocrine Neoplasia Type 1 (Men 1)
Multiple Endocrine Neoplasia Type 2 (Men 2)
Other Disorders Characterized by Multiple Endocrine Organ Involvement
Geriatric Endocrinology
Thyroid Function & Disease
Disorders of the Thyroid Gland
Carbohydrate Intolerance & Diabetes Mellitus
Aging & the Physiology of Carbohydrate Intolerance
Diabetes Mellitus
Nonketotic Hyperosmolar Coma
Osteoporosis & Calcium Homeostasis
Changes in Water Balance
Hyporeninemic Hypoaldosteronism
Glucocorticoids & Stress
Disorders of the Hypothalamic-Pituitary-Adrenal Axis
Changes in Reproductive Function in Men
Benign Prostatic Hyperplasia
Endocrine Emergencies
Myxedema Coma
Thyroid Storm
Thyrotoxic Periodic Paralysis
Amiodarone-Induced Thyrotoxicosis
Acute Adrenal Insufficiency
Pituitary Apoplexy
Diabetic Ketoacidosis
Nonketotic Hyperosmolar Coma
Hypercalcemic Crisis
Acute Hypocalcemia
Diabetes Insipidus
AIDS Endocrinopathies
Thyroid Disorders
Adrenal Disorders
Bone & Mineral Disorders
Gonadal Disorders
Pituitary Disorders
Lipid Disorders
Endocrine Surgery
The Thyroid Gland
Embryology & Anatomy
Developmental Thyroid Abnormalities
Goiter (Nontoxic)
Thyroid Nodules
Thyroid Cancer
Conduct of Thyroidectomy
The Parathyroid Gland
Embryology & Anatomy
Primary Hyperparathyroidism (PHPT)
Persistent & Recurrent Primary Hyperparathyroidism
Secondary Hyperparathyroidism
Special Consideration: Familial Hyperparathyroidism
Complications of Parathyroid Surgery
The Adrenal (Suprarenal) Gland
Embryology & Anatomy
Primary Hyperaldosteronism
Adrenal Cortical Carcinoma
Sex Steroid Excess
Adrenal Incidentaloma
Technique of Adrenalectomy
The Endocrine Pancreas
Embryology & Anatomy
Gastrinoma (Zollinger-Ellison Syndrome)
VIPoma (Verner-Morrison) Syndrome
Nonfunctioning Pancreatic Tumors
Normal Hormone Reference Ranges