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| Foreword | |
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| Acknowledgments | |
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| Introduction | |
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| Roald Hoffmann: Chemistry's Poet Seeks Beauty in Atoms | |
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| Christiane Nusslein-Volhard: "Lady of the Flies" Dives Into a New Pond | |
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| Stephen W. Hawking: Sailing a Wheelchair to the End of Time | |
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| Aaron T. Beck: Pragmatist Embodies His No-Nonsense Therapy | |
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| Edward O. Wilson: From Ants to Ethics: A Biologist Dreams of Unity of Knowledge | |
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| Andrew Wiles: Quiet Conqueror of a 350-Year-Old Enigma | |
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| Temple Grandin: Empathy for Animals, Through the Lens of Autism | |
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| Hans A. Bethe: He Lit Nuclear Fire; Now He Would Douse It | |
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| J. Craig Venter: The Genome's Combative Entrepreneur | |
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| Benjamin S. Carson: Neurosurgeon and Folk Hero | |
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| Abhay Ashtekar: Taste-Testing a Recipe for the Cosmos | |
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| Geerat Vermeij: Getting the Feel of a Long-Ago Arms Race | |
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| John H. Conway: At Home in the Elusive World of Mathematics | |
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| Martha K. McClintock: How Biology Affects Behavior, and Vice Versa | |
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| William Castelli: Preaching the Gospel of Healthy Hearts | |
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| JoAnn M. Burkholder: In a Sealed Lab, a Warrior Against Pollution | |
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| Kary Mullis: After the "Eureka," a Nobelist Drops Out | |
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| Daniel S. Goldin: Bold Remodeler of a Drifting Agency | |
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| Wallace S. Broecker: Iconoclastic Guru of the Climate Debate | |
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| Michael E. DeBakey: Dr. DeBakey at 90: Stringent Standards and a Steady Hand | |
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| Meave Epps Leakey: The New Leader of a Fossil-Hunting Dynasty | |
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| Jim Hammill: A Scientific Passion for Wolves | |
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| Steven Chu: Master of Molecule Manipulation Works on the Wild Side | |
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| Bruce N. Ames: Strong Views on Origins of Cancer | |
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| James D. Watson: Impresario of the Genome Looks Back With Candor | |
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| Rodolfo Llinas: Listening to the Conversation of Neurons | |
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| Michael L. Dertouzos: Unlikely Warrior Leads the Charge for Simpler PC | |
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| Anthony S. Fauci: Consummate Politician on the AIDS Front | |
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| Lene Vestergaard Hau: She Puts the Brakes on Light | |
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| Carlos Cordon-Cardo: Cancer Trailblazer Follows the Genetic Fingerprints | |
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| P. Kirk Visscher: A Life Spent Among Bees Deciphering the Swarm | |
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| Paul C. Sereno: Imp's Evolution to Fossil Finder | |
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| Terry DeBruyn: Black Bears Up Close and Personal | |
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| Benjamin D. Santer: Blaming Humans for a Warmer World | |
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| Richard S. Lindzen: It's Getting Hotter; So What? a Skeptic Asks | |
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| Judith Lea Swain: The Double Life of Dr. Swain: Work and More Work | |
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| Judah Folkman: A Lonely Warrior Against Cancer | |
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| Anne Simon: The Science Adviser to Whaaat? | |
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| Eric Steven Lander: Love of Numbers Leads to Chromosome 17 | |
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| Kathy Schick and Nicholas Toth: Recreating Stone Tools to Learn Makers' Ways | |
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| James W. Cronin: Looking for a Few Good Particles From Outer Space | |
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| Jimmie Holland: Listening to the Emotional Needs of Cancer Patients | |
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| Joe Z. Tsien: Of Smart Mice and the Man Who Made Them That Way | |
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| Carl Safina: High Seas Hunter Pleads for Preservation of Fish | |
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| Mary-Claire King: Quest for Genes and Lost Children | |
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| David A. Summers: Out of the Mines and Into the Lab | |
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| Ellen J. Langer: A Scholar of the Absent Mind | |
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| Gunter Wachtershauser: Amateur Shakes Up Ideas on Recipe for Life | |
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| Steven Weinberg: Physicist Ponders God, Truth and "Final Theory" | |
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| Gary Larson: An Amateur of Biology Returns to His Easel | |
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| Index of Scientists | |