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Therapeutic Antibody Engineering Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

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ISBN-10: 1907568379

ISBN-13: 9781907568374

Edition: 2012

Authors: William R. Strohl, Lila M. Strohl

List price: $220.00
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This title examines all aspects of engineering monoclonal antibodies to make more competitive antibodies and how tthe various genetic engineering approaches will affect candidates of the future.
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Book details

List price: $220.00
Copyright year: 2012
Publisher: Elsevier Science & Technology
Publication date: 10/16/2012
Binding: Hardcover
Pages: 696
Size: 6.14" wide x 9.21" long x 1.50" tall
Weight: 2.486
Language: English

Introduction to biologics and monoclonal antibodies
Value proposition for therapeutic monoclonal antibodies and Fc fusion proteins
Antibody structure-function relationships
Fundamental technologies for antibody engineering
Sources of antibody variable chains
Variable chain engineering - humanization and optimization approaches
Antibody interactions with the immune system
Monoclonal antibody targets and mechanisms of action
Therapeutic antibody classes
Antibody Fc engineering for optimal antibody performance
IgG glycans and glyco-engineering
Antibody fragments as therapeutics
Multiple antibody and multi-specificity approaches
Fc fusion proteins and similar constructs using Fc
Antibody-drug conjugates
Development issues: antibody stability, developability, immunogenicity, and comparability
Interactions of human IgGs with non-human systems
Cell line development
Issues facing therapeutic monoclonal antibodies for the future