Therapeutic Antibody Engineering Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

Name: Therapeutic Antibody Engineering Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry
Price: 186.29 USD
Availability: InStock
ISBN: 9781907568374

ISBN-10: 1907568379

ISBN-13: 9781907568374

Edition: 2012

Authors: William R. Strohl, Lila M. Strohl

List price: $220.00

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Description:

This title examines all aspects of engineering monoclonal antibodies to make more competitive antibodies and how tthe various genetic engineering approaches will affect candidates of the future.

Book details

List price: $220.00
Copyright year: 2012
Publisher: Elsevier Science & Technology
Publication date: 10/16/2012
Binding: Hardcover
Pages: 696
Size: 6.14" wide x 9.21" long x 1.50" tall
Weight: 2.486
Language: English



Introduction to biologics and monoclonal antibodies


Value proposition for therapeutic monoclonal antibodies and Fc fusion proteins


Antibody structure-function relationships


Fundamental technologies for antibody engineering


Sources of antibody variable chains


Variable chain engineering - humanization and optimization approaches


Antibody interactions with the immune system


Monoclonal antibody targets and mechanisms of action


Therapeutic antibody classes


Antibody Fc engineering for optimal antibody performance


IgG glycans and glyco-engineering


Antibody fragments as therapeutics


Multiple antibody and multi-specificity approaches


Fc fusion proteins and similar constructs using Fc


Antibody-drug conjugates


Development issues: antibody stability, developability, immunogenicity, and comparability


Interactions of human IgGs with non-human systems


Cell line development


Issues facing therapeutic monoclonal antibodies for the future