| |
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| How Do We Make Small Things? | |
| |
| |
| Why Bother Making Things Small? | |
| |
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| From Art to Chips | |
| |
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| Photolithography | |
| |
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| Micromachining | |
| |
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| Micromolding | |
| |
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| Soft Lithography | |
| |
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| Hydrogel Devices | |
| |
| |
| Nanofabrication Techniques | |
| |
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| Fabrication Based on Self-Assembly: A "Bottom-Up" Approach | |
| |
| |
| Micropatterning of Substrates and Cells | |
| |
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| Interaction between Surfaces and Biomolecules | |
| |
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| Surface Engineering | |
| |
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| Micropatterns of SAMs | |
| |
| |
| Micropatterns of Proteins | |
| |
| |
| Micropatterns of Cells on Nonbiomolecular Templates | |
| |
| |
| Micropatterns of Cells on Biomolecular Templates | |
| |
| |
| Microfluidics | |
| |
| |
| Why Go Small? | |
| |
| |
| Microscale Behavior of Fluids | |
| |
| |
| Fluids in Electrical Fields | |
| |
| |
| Fluids in Acoustic Fields | |
| |
| |
| Fabrication of Microfluidic Channels | |
| |
| |
| Operation of Microfluidic Channels: Practical Concerns | |
| |
| |
| Droplet Microfluidics | |
| |
| |
| Active Flow Control | |
| |
| |
| Micromixers | |
| |
| |
| Combinatorial Mixers | |
| |
| |
| Molecular Biology on a Chip | |
| |
| |
| The Importance of Miniaturizing Molecular Biology | |
| |
| |
| The Importance of Point-of-Care Diagnostics: Where is Cost Really, Really, Really Important? | |
| |
| |
| Sample Preparation: A Bloody Example | |
| |
| |
| The Problem with Microfluidic Sample Separation | |
| |
| |
| Microfluidic Immunoassays | |
| |
| |
| Chips for Genomics and Proteomics | |
| |
| |
| Electrospray Mass Spectrometry | |
| |
| |
| Biochemical Analysis Using Force Sensors | |
| |
| |
| Cell-Based Chips for Biotechnology | |
| |
| |
| Microfluidic Flow Cytometers | |
| |
| |
| Cell Sorting | |
| |
| |
| Cell Trapping | |
| |
| |
| Microfluidic Cell Culture Laboratories | |
| |
| |
| Gene Expression Cellular Microarrays ("Cellomics") | |
| |
| |
| Micro-Bioreactors | |
| |
| |
| Cells on Microelectrodes | |
| |
| |
| Patch Clamp Chips | |
| |
| |
| Cryopreservation | |
| |
| |
| Assisted Reproductive Technologies | |
| |
| |
| Whole Animal Testing | |
| |
| |
| BioMEMS for Cell Biology | |
| |
| |
| An Enabling Technology: The Hurdles | |
| |
| |
| Cell-Substrate Signaling | |
| |
| |
| Cell-Cell Communication | |
| |
| |
| Cell Migration | |
| |
| |
| BioMEMS for Cellular Neurobiology | |
| |
| |
| Developmental Biology on a Chip | |
| |
| |
| Yeast Biology | |
| |
| |
| Plant Cell Biology | |
| |
| |
| Microfluidics for Studying Cellular Dynamics | |
| |
| |
| Tissue Microengineering | |
| |
| |
| Microscaffolding | |
| |
| |
| Micropatterned Cocultures | |
| |
| |
| Stem Cell Engineering | |
| |
| |
| Morphogenesis | |
| |
| |
| Implantable Microdevices | |
| |
| |
| Dental Implants | |
| |
| |
| Implantable Microelectrodes | |
| |
| |
| Delivery of Soluble Signals into the Body | |
| |
| |
| Microtools for Surgery | |
| |
| |
| Insect Research | |
| |
| |
| Appendix | |
| |
| |
| Index | |
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| |
| A Summary and Further Reading appear at the end of each chapter | |