Absorption and Drug Development Solubility, Permeability, and Charge State

Name: Absorption and Drug Development Solubility, Permeability, and Charge State
Price: 142.47 USD
Availability: InStock
ISBN: 9781118057452

ISBN-10: 1118057457

ISBN-13: 9781118057452

Edition: 2nd 2012

Authors: Alex Avdeef

List price: $142.95

This item qualifies for FREE shipping.

30 day, 100% satisfaction guarantee!

Buy new: $142.47

Marketplace

2 new & used from $166.60

what's this?

Rush Rewards U
Members Receive:

You have reached 400 XP and carrot coins. That is the daily max!

Description:

This book explains how to examine a compound's pharmaceutical properties, emphasizing oral absorption, detailing different physicochemical methods and how to interpret results for analyzing drug candidates. Now in a new edition, this updated volume now includes more case examples, more entries into properties data tables, updated references, and extensive compilations of solubility, permeability, and pKas. With over 600 references and 100 drawings, this book is well-suited for the practical pharmaceutical chemist and those seeking a better understanding of physicochemical measurements.

Book details

List price: $142.95
Edition: 2nd
Copyright year: 2012
Publisher: John Wiley & Sons, Limited
Publication date: 6/8/2012
Binding: Hardcover
Pages: 744
Size: 6.40" wide x 9.40" long x 1.80" tall
Weight: 2.486
Language: English



Preface


Preface to the First Edition


List of Abbreviations


Nomenclature


Commercial Trademarks



Introduction



Bulldozer Searching for a Needle in the Haystack?



As the Paradigm Turns



Screen for the Target or ADME First?



ADME and Multimechanism Screens



ADME and the Medicinal Chemist



The ï¿½Absorptionï¿½ in ADME


It Is Not Just a Number, It Is a Multimechanism


Transport Model


Permeabilityï¿½Solubilityï¿½Charge State and pH-Partition Hypothesis



Octanolï¿½Water