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Absorption and Drug Development Solubility, Permeability, and Charge State

ISBN-10: 1118057457

ISBN-13: 9781118057452

Edition: 2nd 2012

Authors: Alex Avdeef

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Description:

This book explains how to examine a compound's pharmaceutical properties, emphasizing oral absorption, detailing different physicochemical methods and how to interpret results for analyzing drug candidates. Now in a new edition, this updated volume now includes more case examples, more entries into properties data tables, updated references, and extensive compilations of solubility, permeability, and pKas. With over 600 references and 100 drawings, this book is well-suited for the practical pharmaceutical chemist and those seeking a better understanding of physicochemical measurements.
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Book details

Edition: 2nd
Copyright year: 2012
Publisher: John Wiley & Sons, Limited
Publication date: 6/8/2012
Binding: Hardcover
Pages: 744
Size: 6.25" wide x 9.25" long x 1.75" tall
Weight: 2.486
Language: English

Preface
Preface to the First Edition
List of Abbreviations
Nomenclature
Commercial Trademarks
Introduction
Bulldozer Searching for a Needle in the Haystack?
As the Paradigm Turns
Screen for the Target or ADME First?
ADME and Multimechanism Screens
ADME and the Medicinal Chemist
The �Absorption� in ADME
It Is Not Just a Number, It Is a Multimechanism
Transport Model
Permeability�Solubility�Charge State and pH-Partition Hypothesis
Octanol�Water