Absorption and Drug Development Solubility, Permeability, and Charge State
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Edition: 2nd 2012
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This book explains how to examine a compound's pharmaceutical properties, emphasizing oral absorption, detailing different physicochemical methods and how to interpret results for analyzing drug candidates. Now in a new edition, this updated volume now includes more case examples, more entries into properties data tables, updated references, and extensive compilations of solubility, permeability, and pKas. With over 600 references and 100 drawings, this book is well-suited for the practical pharmaceutical chemist and those seeking a better understanding of physicochemical measurements.
Copyright year: 2012
Publisher: John Wiley & Sons, Limited
Publication date: 6/8/2012
Size: 6.40" wide x 9.40" long x 1.80" tall
|Preface to the First Edition|
|List of Abbreviations|
|Bulldozer Searching for a Needle in the Haystack?|
|As the Paradigm Turns|
|Screen for the Target or ADME First?|
|ADME and Multimechanism Screens|
|ADME and the Medicinal Chemist|
|The ï¿½Absorptionï¿½ in ADME|
|It Is Not Just a Number, It Is a Multimechanism|
|Permeabilityï¿½Solubilityï¿½Charge State and pH-Partition Hypothesis|