Edition: 4th 2009 (Revised)
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Description: The newest edition of this acclaimed textbook continues to detail the biochemistry underlying the toxic effects of drugs, pollution, and occupational hazards, especially at the molecular level. It thoroughly explains the dose-response relationship, disposition and metabolism, and toxic responses to foreign compounds. Fully updated, it offers an expanded section on hazard risk assessment and features emerging topics such as biomarkers and oxidative stress, as well as expanded information on a variety of man-made and naturally occurring toxins. Early chapters cover basic principles, which are followed by chapters organized by type of toxicity. Many new examples and diagrams are included.
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All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.
Copyright year: 2009
Publisher: CRC Press LLC
Publication date: 11/18/2008
Size: 7.00" wide x 10.00" long x 1.00" tall
|Biochemical Aspects of Toxicology|
|Fundamentals of Toxicology and Dose-Response Relationships|
|Criteria of Toxicity|
|Evaluation of Toxicity|
|Measurement of Dose-Response Relationships|
|Linear Dose Response|
|Hazard and Risk Assessment|
|Duration and Frequency of Exposure and Effect|
|Factors Affecting Toxic Responses: Disposition|
|Sites of Absorption|
|Factors Affecting Toxic Responses: Metabolism|
|Types of Metabolic Change|
|Phase 1 Reactions|
|Phase 2 Reactions|
|General Summary Points|
|Control of Metabolism|
|Toxication vs. Detoxication|
|Factors Affecting Metabolism and Disposition|
|Toxic Responses to Foreign Compounds|
|Direct Toxic Action: Tissue Lesions|
|Mechanism and Response in Cellular Toxicity|
|Pharmacological, Physiological, and Biochemical Effects|
|Biochemical Mechanisms of Toxicity: Specific Examples|
|Tissue Lesions: Liver Necrosis|
|Tissue Lesions: Kidney Damage|
|Tissue Lesions: Lung Damage|
|Exaggerated and Unwanted Pharmacological Effects|
|Biochemical Effects: Lethal Synthesis and Incorporation|
|Biochemical Effects: Interaction with Specific Protein Receptors|
|Multi-Organ Toxicity: Metals|
|Answers to review questions|