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Biochemical Toxicology

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ISBN-10: 0849373026

ISBN-13: 9780849373022

Edition: 4th 2009 (Revised)

Authors: John A. Timbrell

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Description:

The newest edition of this acclaimed textbook continues to detail the biochemistry underlying the toxic effects of drugs, pollution, and occupational hazards, especially at the molecular level. It thoroughly explains the dose-response relationship, disposition and metabolism, and toxic responses to foreign compounds. Fully updated, it offers an expanded section on hazard risk assessment and features emerging topics such as biomarkers and oxidative stress, as well as expanded information on a variety of man-made and naturally occurring toxins. Early chapters cover basic principles, which are followed by chapters organized by type of toxicity. Many new examples and diagrams are included.
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Book details

Edition: 4th
Copyright year: 2009
Publisher: CRC Press LLC
Publication date: 11/18/2008
Binding: Hardcover
Pages: 464
Size: 7.00" wide x 10.00" long x 1.00" tall
Weight: 1.738
Language: English

Preface
Introduction
Background
Scope
Biochemical Aspects of Toxicology
Summary
Review Questions
Bibliography
Fundamentals of Toxicology and Dose-Response Relationships
Introduction
Biomarkers
Criteria of Toxicity
New Technologies
Evaluation of Toxicity
Interactions
Dose Response
Measurement of Dose-Response Relationships
Linear Dose Response
Hormesis
Hazard and Risk Assessment
Duration and Frequency of Exposure and Effect
Summary
Review Questions
References
Bibliography
Factors Affecting Toxic Responses: Disposition
Introduction
Absorption
Sites of Absorption
Distribution
Excretion
Summary
Review Questions
References
Bibliography
Factors Affecting Toxic Responses: Metabolism
Introduction
Types of Metabolic Change
Phase 1 Reactions
Phase 2 Reactions
General Summary Points
Control of Metabolism
Toxication vs. Detoxication
Summary
Review Questions
References
Bibliography
Factors Affecting Metabolism and Disposition
Introduction
Chemical Factors
Biological Factors
Summary
Review Questions
References
Bibliography
Toxic Responses to Foreign Compounds
Introduction
Direct Toxic Action: Tissue Lesions
Mechanism and Response in Cellular Toxicity
Pharmacological, Physiological, and Biochemical Effects
Developmental Toxicology-Teratogenesis
Immunotoxicity
Genetic Toxicity
Chemical Carcinogenesis
Summary
Review Questions
References
Bibliography
Biochemical Mechanisms of Toxicity: Specific Examples
Chemical Carcinogenesis
Tissue Lesions: Liver Necrosis
Tissue Lesions: Kidney Damage
Tissue Lesions: Lung Damage
Neurotoxicity
Exaggerated and Unwanted Pharmacological Effects
Physiological Effects
Biochemical Effects: Lethal Synthesis and Incorporation
Biochemical Effects: Interaction with Specific Protein Receptors
Teratogenesis
Immunotoxicity
Multi-Organ Toxicity
Multi-Organ Toxicity: Metals
Summary
Review Questions
References
Bibliography
Glossary
Answers to review questions
Index
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