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The Nature of Physical Evidence | |
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Science and the Law | |
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Principles and Processes of Criminalistics | |
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The Principles | |
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The Processes | |
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Identification | |
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Classification and Individualization | |
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Association | |
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Reconstruction | |
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Fingerprints and DNA | |
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Conventional Blood Typing | |
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The Collection and Preservation of Physical Evidence | |
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Extraneous Substances | |
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Collection of Evidence | |
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Preservation of Evidence | |
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Evaluation of Evidence | |
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RFLP | |
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PCR | |
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A Short History of DNA Typing | |
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The Scientific Basis of DNA Typing | |
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Why DNA? | |
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An Introduction to Human Genetics | |
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The Physical Basis of Heredity | |
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Alleles: Variations on a Theme | |
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Population Genetics | |
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An Introduction to the Molecular Biology of DNA | |
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Two Kinds of Variation | |
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Enzymes: The Workhorses of the Biological World | |
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An Overview of Forensic DNA Typing Systems | |
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RELP Analysis | |
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PCR Amplification | |
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HLA DQ[alpha]/HLA DQA1 | |
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AmpliType PM | |
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D1S80 | |
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STRs | |
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Gender Identification | |
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Y-STRs | |
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Mitochondrial DNA | |
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What Kinds of Samples Can be Analyzed? | |
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How Much Sample Do You Need? | |
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Procedures for Forensic DNA Analysis | |
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Isolation of DNA | |
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Chelex Extraction | |
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QiaAmp Extraction | |
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Organic Extraction | |
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Differential Extraction | |
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Determining the Quality and Quantity of DNA | |
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Determination of Quantity | |
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Determination of Quality | |
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RFLP Analysis | |
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PCR Amplification | |
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Analysis of PCR Product | |
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Sequence Polymorphisms | |
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AmpliType PM+DQA1 | |
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Mitochondrial DNA (mtDNA) | |
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Length Polymorphisms (D1S80, STRs, Gender ID) | |
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Automated Analysis Systems | |
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Automated DNA Extraction and Amplification | |
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Liquid Blood Transfer | |
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DNA Extraction | |
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Quantitation | |
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Amplification | |
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Robot Issues | |
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Summary of Automated Procedures | |
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Interpretation of DNA Typing Results | |
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Complicating Factors | |
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Multiple Contributors | |
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Sexual Assault Evidence | |
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Non-sexual Assault Mixtures | |
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Degradation | |
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Extraneous Substances | |
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Chemical Inhibition of Enzymes | |
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Non-human DNA | |
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System-Specific Interpretational Issues | |
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RFLP | |
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Multi-(More Than Two) Banded Patterns | |
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Single-Banded Patterns | |
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Summary of RFLP Interpretational Issues | |
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PCR Systems | |
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Nuclear DNA | |
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Mitochondrial DNA | |
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Summary of PCR Systems Interpretational Issues | |
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Summary of DNA Interpretation Issues | |
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Assessing the Strength of the Evidence | |
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Determination of Genetic Concordance | |
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Continuous Allele Systems | |
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Discrete Allele Systems | |
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Evaluation of Results | |
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Frequency Estimate Calculations | |
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Population Substructure | |
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Estimating Frequencies | |
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Continuous Allele Systems (RFLP) | |
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Discrete Allele Systems (all PCR systems) | |
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Correction Factors | |
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Relatives | |
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Counting Method | |
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Error Rates | |
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Likelihood Ratios | |
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What Is the Question? | |
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Complex Evidence | |
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Mixtures | |
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Articulating the Hypothesis | |
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When Is a DNA Profile Unique | |
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The DNA Databank | |
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Premise of a Databank | |
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The Difference Between a Databank and a Database | |
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Elements of a Successful Databank | |
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Legislation | |
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Collection of Samples | |
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Offenders | |
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Cases | |
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Analysis of Samples | |
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Choice of Markers | |
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Offenders | |
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Cases | |
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Transforming Analyzed Data into a Database | |
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The Computer Program | |
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Communication Between Laboratories | |
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Privacy | |
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Flow of Offender Data into the Databank | |
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Import of Profiles into the Database | |
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Categories and Indexes | |
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Searching Profiles | |
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Confirmation of a Match | |
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United States Statistics | |
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Summary | |
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Quality Assurance | |
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Certification and Accreditation | |
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Certification | |
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Accreditation | |
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SWDAM (Formerly TWGDAM) | |
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NRC I and II | |
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NRC I | |
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NRC II | |
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Federal DNA Advisory Board | |
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Admissibility Standards: Science on Trial in the Courtroom | |
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Frye, Daubert, and the Federal Rules of Evidence | |
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The Frye Standard | |
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The Federal Rules of Evidence | |
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The Daubert Standard | |
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Past Admissibility | |
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DNA: Some Landmark Cases | |
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RFLP | |
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PCR: DQ[alpha]/A1, Polymarker, D1S80 | |
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PCR: STRs | |
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Mitochondrial DNA | |
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The State of the Debate | |
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Epilogue | |
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Glossary | |
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Key Phrases | |
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Assessment Tools | |
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Chromosomal Locations | |
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Profile Frequency Calculation | |
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Likelihood Ratio and Probability of Exclusion | |
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DAB 98 | |
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DAB Statistics | |
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NRC I, II | |
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DNA Statutes | |
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DNA Decision Summary | |
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List STR decisions | |
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Internet Resources | |
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Index | |