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Toxicology of Industrial Compounds

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ISBN-10: 074840239X

ISBN-13: 9780748402397

Edition: 1995

Authors: Helmut Thomas, Robert Hess, Felix Waechter

List price: $159.95
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Description:

A large number of chemical compunds are constantly being introduced and produced, both to assist and ease modern human life. Among these chemicals, industrial compounds represent a particular fraction of chemicals which are not intended for use in biological systems, but to which humans may be accidently exposed, whether in the workplace, by product application, or via the environment. Industrial chemicals, as opposed to pharmaceuticals and agrochemicals, are in many cases subjected only to a very basic examination of handling safety, and may lack further toxicity testing. This implies that essentially nothing is known about their bioavailability, metabolism, excretion and toxicological properties, unless problems arise.; Covering the investigation of industrial chemicals, this book focuses on their individual structure, biological fate, potential toxicity to mammals and the molecular mechanisms possibly underlying their adverse effects by highlighting the use and significance of experimental toxicology.Special emphasis is placed on mechanistic aspects in the safety assessment of industrial compounds, in addition to current regulatory and legal considerations.
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Book details

List price: $159.95
Copyright year: 1995
Publisher: CRC Press LLC
Publication date: 11/21/1995
Binding: Hardcover
Pages: 381
Size: 6.50" wide x 9.50" long x 1.00" tall
Weight: 1.694
Language: English

Preface
List of Contributors
Biomonitoring and Absorption of Industrial Chemicals: the Challenge of Organic Solvents
Toxicokinetics and Biodisposition of Industrial Chemicals
Metabolic Activation of Industrial Chemicals and Implications for Toxicity
Sizing Up the Problem of Exposure Extrapolation: New Directions in Allometric Scaling
Metabolism of Reactive Chemicals
Methods for the Determination of Reactive Compounds
Studies to Assess the Carcinogenic Potential of Man-Made Vitreous Fibers
Pulmonary Toxicity Studies with Man-Made Organic Fibres: Preparation and Comparisons of Size-separated Para-aramid with Chrysotile Asbestos Fibres
Pulmonary Hyperreactivity to Industrial Pollutants
Mechanisms of Pulmonary Sensitization
Occupational Asthma Induced by Chemical Agents
Biomarkers and Risk Assessment
Extrapolation of Toxicity Data and Assessment of Risk
Molecular Approaches to Assess Cancer Risks
Evaluation of Toxicity to the Immune System
New Strategies: the Use of Long-term Cultures of Hepatocytes in Toxicity Testing and Metabolism Studies of Chemical Products Other than Pharmaceuticals
Peroxisome Proliferation
Neurotoxicity Testing of Industrial Compounds: in vivo Markers and Mechanisms of Action
Endocrine Toxicology of the Thyroid for Industrial Compounds
Testing and Evaluation for Reproductive Toxicity
Special Points in the Toxicity Assessment of Colorants (Dyes and Pigments)
Toxicology of Textile Chemicals
Antioxidants and Light Stabilisers: Toxic Effects of 3,5-Dialkyl-hydroxyphenyl Propionic Acid Derivatives in the Rat and their Relevance for Human Safety Evaluation
Toxicology of Surfactants: Molecular, Mechanistic and Regulatory Aspects
Low Dose of a Genotoxic Carcinogen does not 'Cause' Cancer; it Accelerates Spontaneous Carcinogenesis
Controversial Mechanistic and Regulatory Issues in Safety Assessment of Industrial Chemicals - an Industry Point of View
Index