Robustness and Evolvability in Living Systems

Name: Robustness and Evolvability in Living Systems
Price: 27.75 USD
Availability: InStock
ISBN: 9780691134048

ISBN-10: 0691134049

ISBN-13: 9780691134048

Edition: 2005

Authors: Andreas Wagner

List price: $74.00

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Description:

In spite of their enormous complexity, living things continue to function in the face of constant change. The reason is that evolution by natural selection preferentially finds and favours robust solutions to the problems organisms face in surviving and reproducing.

Book details

List price: $74.00
Copyright year: 2005
Publisher: Princeton University Press
Publication date: 7/22/2007
Binding: Paperback
Pages: 368
Size: 6.10" wide x 9.21" long x 0.80" tall
Weight: 1.122
Language: English



List of Figures


Acknowledgments



Introduction



Robustness Below the Gene Level



The Genetic Alphabet



The Genetic Code



RNA Structure



Proteins and Point Mutations



Proteins and Recombination



Robustness Above the Gene Level



Regulatory DNA Regions and Their Reorganization in Evolution



Metabolic Pathways



Metabolic Networks



Drosophila Segmentation and Other Gene Regulatory Networks



Phenotypic Traits, Cryptic Variation, and Human Diseases



The Many Ways of Building the Same Body



Common Principles



Neutral Spaces



Evolvability and Neutral Mutations



Redundancy of Parts or Distributed Robustness?



Robustness as an Evolved Adaptation to Mutations



Robustness as an Evolved Adaptation to Environmental Change and Noise



Robustness and Fragility: Advantages to Variation and Trade-offs



Robustness Beyond the Organism



Robustness in Natural Systems and Self-Organization



Robustness in Man-made Systems


Epilogue: Seven Open Questions for Systems Biology


Bibliography


Index