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Thrombosis and Hemorrage

ISBN-10: 0683301144

ISBN-13: 9780683301144

Edition: 2nd 1998 (Revised)

Authors: Joseph Loscalzo, Andrew I. Schafer

List price: $229.00
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Description:

Focusing on thrombosis and haemorrhage, this resource covers haemostasis from cellular and molecular mechanisms to practical insights on clinical management.
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Book details

List price: $229.00
Edition: 2nd
Copyright year: 1998
Publisher: Lippincott Williams & Wilkins
Binding: Cloth Text 
Pages: 1400
Size: 9.00" wide x 11.25" long x 2.00" tall
Weight: 7.986
Language: English

Anthony S. Fauci, MD, ScD(HON) Chief, Laboratory of Immunoregulation; Director, National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, MDEugene Braunwald, MD, ScD(HON) Distinguished Hersey Professor of Medicine Harvard Medical School; Chairman, TIMI Study Group Brigham and Women's Hospital, Boston, MADennis L. Kasper, MD, MA(HON) William Ellery Channing Professor of Medicine Professor of Microbiology and Molecular Genetics Harvard Medical School; director, Channing Laboratory Department of Medicine, Brigham and Women's Hospital, Boston, MAStephen L. Hauser, MD Robert A. Fishman Distinguished Professor and Chairman Department of Neurology, University of California, San Francisco San Francisco, CADan L. Longo, MD Scientific Director, National Institute on Aging National Institutes of Health, Bethesda, MDJ. Larry Jameson, MD, PhD Professor of Medicine Vice President for Medical Affairs and Lewis Landsberg Dean Northwestern University, Feinberg School of Medicine Chicago, ILJoseph Loscalzo, MD, PhD Hersey Professor of the Theory and Practice of Medicine Harvard Medical School; Chairman, Department of Medicine Physician-in-Chief, Brigham and Women's Hospital, Boston, MA

Preface
Acknowledgment
Contributors
Coagulation and Fibrinolysis
Coagulation Cascade: An Overviewp. 3
Molecular Genetics of Blood Coagulationp. 29
Regulation of Coagulationp. 45
The Tissue Factor Pathway of Coagulationp. 77
Contact Activationp. 105
Fibrin Formation and Stabilizationp. 129
Fibrinolysis and Its Regulationp. 155
Platelets
Regulation of Megakaryopoiesisp. 173
Platelet Turnoverp. 195
Platelet Morphologyp. 207
Platelet Membranes and Receptorsp. 229
Mechanisms of Platelet Activationp. 261
Vessel Wall
Overview of the Endotheliump. 295
The Vascular Response to Injuryp. 307
Interactions of Leukocytes with the Vessel Wallp. 321
von Willebrand Factorp. 337
Interaction of Coagulation Factors with the Vessel Wallp. 365
Interaction of the Fibrinolytic System with the Vessel Wallp. 373
Endothelium-Derived Vasoactive Factorsp. 387
Rheologyp. 405
Experimental Models
Experimental Models of Thrombosis and Thrombolysisp. 425
Genetic Models of Thrombosis and Hemorrhagep. 435
Clinical Approach to Bleeding and Thrombosis
Approach to Bleedingp. 459
Approach to Thrombosisp. 477
Assessment of Arterial and Venous Thrombosisp. 491
Laboratory Methods in Hemostasisp. 517
Quantitative Platelet Disorders
Thrombotic Microangiopathies: Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndromep. 583
The Alloimmune Thrombocytopeniasp. 599
Drug-Induced Thrombocytopeniasp. 617
Immune Thrombocytopenic Purpurap. 643
Thrombocytosisp. 665
Qualitative Platelet Disorders
Congenital Disorders of Platelet Functionp. 683
Acquired Disorders of Platelet Functionp. 707
Disorders of Coagulation Factors and Fibrinolysis
von Willebrand Diseasep. 729
Hemophilia-Factor VIII Deficiencyp. 757
Other Coagulation Factor Deficienciesp. 773
Factor VIII and Other Coagulation Factor Inhibitorsp. 803
Antiphospholipid Syndrome, Lupus Anticoagulants, and Anticardiolipin Antibodiesp. 817
Thrombotic Disorders
The Relationship between Thrombosis and Atherosclerosisp. 837
Inherited and Acquired Hypercoagulable Statesp. 863
Endotheliopathies: Clinical Manifestations of Endothelial Dysfunctionp. 901
Interaction of Blood and Artificial Surfacesp. 925
Other Disorders of Hemostasis
Vascular Purpura and Diseases of Blood Vesselsp. 945
Disseminated Intravascular Coagulationp. 963
Coagulopathy of Liver Failure and Vitamin K Deficiencyp. 987
Maternal Hemostasis: Coagulation Problems of Pregnancyp. 1005
Hemorrhage, Thrombosis, and Antithrombotic Therapy in Childrenp. 1027
Hemostatic Complications of HIV Infectionp. 1065
Hemostatic Complications of Blood and Bone Marrow Transplantationp. 1077
Effects of Cardiopulmonary Bypass on Hemostasisp. 1091
Management of Bleeding
Platelet Transfusion Therapyp. 1119
Plasma and Component Therapyp. 1135
NonTransfusional Modalitiesp. 1163
Management of Thrombosis
Pharmacology of Antiplatelet Agentsp. 1181
Pharmacology of Heparin and Oral Anticoagulantsp. 1193
Pharmacology of Thrombolytic Agentsp. 1215
New Antithrombotic Strategiesp. 1259
Antithrombotic Interventions in Cerebrovascular Diseasep. 1279
Antithrombotic Therapy in Cardiovascular Diseasep. 1309
Anticoagulants in Atrial Fibrillationp. 1337
Prevention and Treatment of Venous Thromboembolic Diseasep. 1351
Gene Therapy of Thrombotic and Hemorrhagic Disordersp. 1377
Index
Table of Contents provided by Blackwell. All Rights Reserved.