Preface | |
Acknowledgment | |
Contributors | |
Coagulation and Fibrinolysis | |
Coagulation Cascade: An Overview | p. 3 |
Molecular Genetics of Blood Coagulation | p. 29 |
Regulation of Coagulation | p. 45 |
The Tissue Factor Pathway of Coagulation | p. 77 |
Contact Activation | p. 105 |
Fibrin Formation and Stabilization | p. 129 |
Fibrinolysis and Its Regulation | p. 155 |
Platelets | |
Regulation of Megakaryopoiesis | p. 173 |
Platelet Turnover | p. 195 |
Platelet Morphology | p. 207 |
Platelet Membranes and Receptors | p. 229 |
Mechanisms of Platelet Activation | p. 261 |
Vessel Wall | |
Overview of the Endothelium | p. 295 |
The Vascular Response to Injury | p. 307 |
Interactions of Leukocytes with the Vessel Wall | p. 321 |
von Willebrand Factor | p. 337 |
Interaction of Coagulation Factors with the Vessel Wall | p. 365 |
Interaction of the Fibrinolytic System with the Vessel Wall | p. 373 |
Endothelium-Derived Vasoactive Factors | p. 387 |
Rheology | p. 405 |
Experimental Models | |
Experimental Models of Thrombosis and Thrombolysis | p. 425 |
Genetic Models of Thrombosis and Hemorrhage | p. 435 |
Clinical Approach to Bleeding and Thrombosis | |
Approach to Bleeding | p. 459 |
Approach to Thrombosis | p. 477 |
Assessment of Arterial and Venous Thrombosis | p. 491 |
Laboratory Methods in Hemostasis | p. 517 |
Quantitative Platelet Disorders | |
Thrombotic Microangiopathies: Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome | p. 583 |
The Alloimmune Thrombocytopenias | p. 599 |
Drug-Induced Thrombocytopenias | p. 617 |
Immune Thrombocytopenic Purpura | p. 643 |
Thrombocytosis | p. 665 |
Qualitative Platelet Disorders | |
Congenital Disorders of Platelet Function | p. 683 |
Acquired Disorders of Platelet Function | p. 707 |
Disorders of Coagulation Factors and Fibrinolysis | |
von Willebrand Disease | p. 729 |
Hemophilia-Factor VIII Deficiency | p. 757 |
Other Coagulation Factor Deficiencies | p. 773 |
Factor VIII and Other Coagulation Factor Inhibitors | p. 803 |
Antiphospholipid Syndrome, Lupus Anticoagulants, and Anticardiolipin Antibodies | p. 817 |
Thrombotic Disorders | |
The Relationship between Thrombosis and Atherosclerosis | p. 837 |
Inherited and Acquired Hypercoagulable States | p. 863 |
Endotheliopathies: Clinical Manifestations of Endothelial Dysfunction | p. 901 |
Interaction of Blood and Artificial Surfaces | p. 925 |
Other Disorders of Hemostasis | |
Vascular Purpura and Diseases of Blood Vessels | p. 945 |
Disseminated Intravascular Coagulation | p. 963 |
Coagulopathy of Liver Failure and Vitamin K Deficiency | p. 987 |
Maternal Hemostasis: Coagulation Problems of Pregnancy | p. 1005 |
Hemorrhage, Thrombosis, and Antithrombotic Therapy in Children | p. 1027 |
Hemostatic Complications of HIV Infection | p. 1065 |
Hemostatic Complications of Blood and Bone Marrow Transplantation | p. 1077 |
Effects of Cardiopulmonary Bypass on Hemostasis | p. 1091 |
Management of Bleeding | |
Platelet Transfusion Therapy | p. 1119 |
Plasma and Component Therapy | p. 1135 |
NonTransfusional Modalities | p. 1163 |
Management of Thrombosis | |
Pharmacology of Antiplatelet Agents | p. 1181 |
Pharmacology of Heparin and Oral Anticoagulants | p. 1193 |
Pharmacology of Thrombolytic Agents | p. 1215 |
New Antithrombotic Strategies | p. 1259 |
Antithrombotic Interventions in Cerebrovascular Disease | p. 1279 |
Antithrombotic Therapy in Cardiovascular Disease | p. 1309 |
Anticoagulants in Atrial Fibrillation | p. 1337 |
Prevention and Treatment of Venous Thromboembolic Disease | p. 1351 |
Gene Therapy of Thrombotic and Hemorrhagic Disorders | p. 1377 |
Index | |
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