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| Preface | |
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| Acknowledgments | |
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| Fundamentalsof NMR Spectroscopy in Liquids | |
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| Introduction to NMR Spectroscopy | |
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| Examples: NMR Spectroscopy of Oligosaccharides and Terpenoids | |
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| Typical Values of Chemical Shifts and Coupling Constants | |
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| Fundamental Concepts of NMR Spectroscopy | |
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| Interpretation of Proton (1H) NMR Spectra | |
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| Assignment | |
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| Effect of Bo Field Strength on the Spectrum | |
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| First-Order Splitting Patterns | |
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| The Use of 1H-1H Coupling Constants to Determine Stereochemistry and Conformation | |
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| Symmetry and Chirality in NMR | |
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| The Origin of the Chemical Shift | |
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| J Coupling to Other NMR-Active Nuclei | |
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| Non-First-Order Splitting Patterns: Strong Coupling | |
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| Magnetic Equivalence | |
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| NMR Hardware and Software | |
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| Sample Preparation | |
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| Sample Insertion | |
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| The Deuterium Lock Feedback Loop | |
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| The Shim System | |
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| Tuning and Matching the Probe | |
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| NMR Data Acquisition and Acquisition Parameters | |
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| Noise and Dynamic Range | |
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| Special Topic: Oversampling and Digital Filtering | |
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| NMR Data Processing-Overview | |
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| The Fourier Transform | |
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| Data Manipulation Before the Fourier Transform | |
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| Data Manipulation After the Fourier Transform | |
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| Carbon-13 ( 13 C) NMR Spectroscopy | |
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| Sensitivity of 13 C | |
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| Splitting of 13 C Signals | |
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| Decoupling | |
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| Heteronuclear Decoupling: 1 H Decoupled 13C Spectra | |
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| Decoupling Hardware | |
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| Decoupling Software: Parameters | |
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| The Nuclear Overhauser Effect (NOE) | |
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| Heteronuclear Decoupler Modes | |
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| NMR Relaxation-Inversion-Recovery and the Nuclear Overhauser Effect (NOE) | |
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| The Vector Model | |
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| One Spin in a Magnetic Field | |
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| A Large Population of Identical Spins: Net Magnetization | |
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| Coherence: Net Magnetization in the x-y Plane | |
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| Relaxation | |
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| Summary of the Vector Model | |
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| Molecular Tumbling and NMR Relaxation | |
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| Inversion-Recovery: Measurement of T 1 Values | |
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| Continuous-Wave Low-Power Irradiation of One Resonance | |
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| Homonuclear Decoupling | |
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| Presaturation of Solvent Resonance | |
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| The Homonuclear Nuclear Overhauser Effect (NOE) | |
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| Summary of the Nuclear Overhauser Effect | |
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| The Spin Echo and the Attached Proton Test (APT) | |
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| The Rotating Frame of Reference | |
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| The Radio Frequency (RF) Pulse | |
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| The Effect of RF Pulses | |
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| Quadrature Detection, Phase Cycling, and the Receiver Phase | |
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| Chemical Shift Evolution | |
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| Scalar (J) Coupling Evolution | |
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| Examples of J-coupling and Chemical Shift Evolution | |
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| The Attached Proton Test (APT) | |
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| The Spin Echo | |
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| The Heteronuclear Spin Echo: Controlling J-Coupling Evolution and Chemical Shift Evolution | |
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| Coherence Transfer: INEPT and DEPT | |
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| Net Magnetization | |
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| Magnetization Transfer | |
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| The Product Operator Formalism: Introduction | |
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| Single Spin Product Operators: Chemical Shift Evolution | |
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| Two-Spin Operators: J-coupling Evolution and Antiphase Coherence | |
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| The Effect of RF Pulses on Product Operators | |
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| INEPT and the Transfer of Magnetization from 1 H to 13 C | |
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| Selective Population Transfer (SPT) as a Way of Understanding INEPT Coherence Transfer | |
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| Phase Cycling in INEPT | |
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| Intermediate States in Coherence Transfer | |
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| Zero- and Double-Quantum Operators | |
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| Summary of Two-Spin Operators | |
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| Refocused INEPT: Adding Spectral Editing | |
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| DEPT: Distortionles | |