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Preface | |
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Acknowledgements | |
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Note on the tenth edition | |
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How to use this book | |
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Further reading | |
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List of abbreviations | |
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Immunity | |
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The scope of immunology | |
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Innate and adaptive immune mechanisms | |
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Recognition and receptors: the keys to immunity | |
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Cells involved in immunity: the haemopoietic system | |
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Innate immunity | |
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Receptors of the innate immune system | |
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Complement | |
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Acute infl ammation | |
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Phagocytic cells and the reticuloendothelial system | |
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Phagocytosis | |
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Adaptive immunity | |
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The molecular basis | |
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Evolution of recognition molecules: the immunoglobulin superfamily | |
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The major histocompatibility complex | |
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The T-cell receptor | |
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Antibody diversifi cation and synthesis | |
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Antibody structure and function | |
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The cellular basis | |
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Lymphocytes | |
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Primary lymphoid organs and lymphopoiesis | |
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Secondary lymphoid organs and lymphocyte traffic | |
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The adaptive immune response | |
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Antigen processing and presentation | |
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The antibody response | |
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Antigen - antibody interaction and immune complexes | |
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Cell-mediated immune responses | |
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Regulation | |
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Tolerance | |
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Cell communication and cytokines | |
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The cytokine network | |
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Immunity, hormones and the brain | |
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Potentially useful immunity | |
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Antimicrobial immunity: a general scheme | |
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Immunity to viruses | |
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HIV and AIDS | |
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Immunity to bacteria | |
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Immunity to fungi and ectoparasites | |
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Immunity to protozoa | |
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Immunity to worms | |
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Undesirable effects of immunity | |
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Immunodeficiency | |
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Harmful immunity: a general scheme | |
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Allergy and anaphylaxis | |
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Immune complexes, complement and disease | |
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Chronic and cell-mediated infl ammation | |
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Autoimmune disease | |
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Altered immunity | |
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Transplant rejection | |
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Immunosuppression | |
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Immunostimulation and vaccination | |
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Immunity in health and disease | |
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Cancer immunology | |
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Immunity and clinical medicine | |
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Investigating immunity | |
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Immunology in the laboratory | |
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Out of the past: evolution of immune mechanisms | |
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Into the future: immunology in the age of genomics | |
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Self-assessment | |
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Self-assessment questions | |
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Answers | |
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Appendices | |
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Comparative sizes and molecular weights | |
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Landmarks in the history of immunology and some unsolved problems | |
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CD classification | |
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Index | |