Medical Biochemistry at a Glance

ISBN-10: 0470654511

ISBN-13: 9780470654514

Edition: 3rd 2012

Authors: J. G. Salway

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Medical Biochemistry at a Glance is a concise, illustrated summary of biochemistry and its relevance to clinical medicine. It is intended for students of medicine and the biomedical sciences such as nutrition, biochemistry, sports science, medical laboratory sciences, physiotherapy, pharmacy, physiology, pharmacology and veterinary science. It also provides a succinct review and reference for medical practitioners and biomedical scientists who need quickly to refresh their knowledge of medical biochemistry.The book is designed as a revision guide for students preparing for examinations and contains topics that have been identified as high–yield facts for the United States Medical Licensing Examination (USMLE), Step 1.This third edition of Medical Biochemistry at a Glance has been thoroughly revised and updated to include a four colour presentation, updated and improved clinical correlates and a companion website containing self–assessment questions and answers.
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Book details

List price: $29.99
Edition: 3rd
Copyright year: 2012
Publisher: John Wiley & Sons, Limited
Publication date: 1/20/2012
Binding: Paperback
Pages: 176
Size: 8.75" wide x 11.00" long x 0.50" tall
Weight: 1.100
Language: English

Preface to the third edition
Acknowledgements to the third edition
Figure key
SI/mass unit conversions
Acids, bases and pH
Acids, bases and hydrogen ions (protons)
Understanding pH
Production and removal of protons into and from the blood
Metabolic alkalosis and metabolic acidosis
Respiratory alkalosis and respiratory acidosis
Structure of amino acids and proteins
Amino acids and the primary structure of proteins
Secondary structure of proteins
Tertiary and quaternary structure and collagen
Formation of ATP: oxidation and reduction reactions
Oxidation/reduction reactions, coenzymes and prosthetic groups
Anaerobic production of ATP by substrate-level phosphorylation, from phosphocreatine and by the adenylate kinase (myokinase) reaction
Aerobic production of ATP
Biosynthesis of ATP by oxidative phosphorylation I
Biosynthesis of ATP by oxidative phosphorylation II
What happens when protons or electrons leak from the respiratory chain?
Free radicals, reactive oxygen species and oxidative damage
Aerobic oxidation of glucose to provide energy as ATP
Anaerobic oxidation of glucose by glycolysis to form ATP and lactate
Anaerobic glycolysis in red blood cells, 2,3-BPG (2,3-DPG) and the Bohr effect
Absorption of carbohydrates and metabolism of galactose
Fate of glucose in liver: glycogenesis and lipogenesis
Fructose metabolism
Glucose homeostasis
Glucose-stimulated secretion of insulin from �-cells
Regulation of glycogen metabolism
Glycogen breakdown (glycogenolysis) and glycogen storage diseases
Insulin signal transduction and diabetes mellitus
Diabetes mellitus
Alcohol metabolism: hypoglycaemia, hyperlactataemia and steatosis
Enzymes and regulation of pathways
Enzymes: nomenclature, kinetics and inhibitors
Regulation of enzyme activity
Regulation of glycolysis and Krebs cycle
Oxidation of fatty acids to produce ATP in muscle and ketone bodies in liver
Regulation of lipolysis, �-oxidation, ketogenesis and gluconeogenesis
Lipids and lipid metabolism
Structure of lipids
Phospholipids I: phospholipids and sphingolipids
Phospholipids II: micelles, liposomes, lipoproteins and membranes
Metabolism of carbohydrate to cholesterol
VLDL and LDL metabolism I: "forward" cholesterol transport
VLDL and LDL metabolism II: endogenous triacylglycerol transport
HDL metabolism: "reverse" cholesterol transport
Absorption and disposal of dietary triacylglycerols and cholesterol by chylomicrons
Steroid hormones: aldosterone, cortisol, androgens and oestrogens
Metabolism of amino acids and porphyrins
Urea cycle and overview of amino acid catabolism
Non-essential and essential amino acids
Amino acid metabolism: to energy as ATP; to glucose and ketone bodies
Amino acid disorders: maple syrup urine disease, homocystinuria, cystinuria, alkaptonuria and albinism
Phenylalanine and tyrosine metabolism in health and disease
Products of tryptophan and histidine metabolism
Haem, bilirubin and porphyria
Fat-soluble vitamins I: vitamins A and D
Fat-soluble vitamins II: vitamins E and K
Water-soluble vitamins I: thiamin, ribofl avin, niacin and pantothenate
Water-soluble vitamins II: pyridoxal phosphate (B6)
Water-soluble vitamins III: folate and vitamin B12
Water-soluble vitamins IV: biotin and vitamin C
Molecular biology
The cell cycle
Pyrimidine metabolism
Purine metabolism
Structure of DNA
The "central dogma" of molecular biology
Organisation of DNA in chromosomes
Replication of DNA (part 1)
Replication of DNA (part 2)
DNA damage and repair
Transcription of DNA to make messenger RNA (part 1)
Transcription of DNA to make messenger RNA (part 2)
Transcription of DNA to make transfer RNA
Transcription of DNA to make ribosomal RNA
Translation and protein synthesis
Comparison of DNA replication, DNA transcription and protein synthesis in eukaryotes and prokaryotes
Diagnostic clinical biochemistry
Diagnostic clinical biochemistry
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