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| Introduction | |
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| What is Mass Spectrometry | |
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| History | |
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| Applications | |
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| The Data of Mass Spectrometry and Its Presentation | |
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| Spectra | |
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| Total Ion Current | |
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| Mass Chromatograms and Profiles | |
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| Definition of Terms | |
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| Mass-To-Charge Ratio (m/z) | |
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| Multiple-Charge Ions | |
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| Ions Representing an Intact Molecule | |
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| Resolution/Resolving Power | |
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| Intensity vs Abundance | |
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| The Mass Spectrometer | |
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| Introduction | |
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| Ion Guides | |
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| Types of m/z Analyzers | |
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| Time-Of-Flight | |
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| Linear.1) Resolving Power of the Linear TOF Instrument.2) Time-Lag Focusing.3) Beam Deflection | |
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| Reflectron | |
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| Orthogonal Acceleration | |
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| Ion Detection in the TOF Analyzer.1) Time Slice Detection.2) Time Array Detection.3) TAD with Transient Recorders.4) TAD with an Integrating Transient Recorder.5) Hadamard Transform TOF MS | |
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| Quadrupole Ion Traps | |
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| 3D Quadrupole Ion Traps | |
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| Linear Quadrupole Ion Traps | |
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| Orbitrap | |
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| Historical Aspects | |
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| Operating Principles | |
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| Transmission Quadrupoles | |
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| QMF Equations of Motion | |
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| The Stability Diagram | |
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| Characteristics of Output | |
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| Spectral Skewing | |
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| Performance Limitations | |
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| Sector instruments | |
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| Single-focusing Instruments.1) Operating Principles.2) Performance Limitations | |
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| Double-Focusing Instruments | |
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| FTICR-MS | |
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| Hardware Configuration | |
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| Operational Considerations | |
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| Representative Applications | |
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| Calibration of the m/z Scale | |
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| Electron Ionizaton (GC/MS) | |
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| Chemical Ionization (GC/MS) | |
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| Electrospray and Other Atmospheric Pressure Ionization Techniques | |
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| Ion Detection | |
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| General Considerations | |
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| Types of Detectors | |
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| Faraday Cup | |
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| Electron Multiplier.1) Discrete-Dynode Version.2) Continuous-Dynode Version | |
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| Negative-Ion Detection | |
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| Post-Acceleration Detection and Detection of High-Mass Ions | |
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| Channel Electron Multiplier Array (CEMA) | |
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| Electro-Optical Ion Detection | |
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| The Daly Detector | |
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| Cryogenic Detectors | |
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| Vacuum Systems | |
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| Introduction | |
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| Definitions | |
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| Pressure Gauges | |
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| Thermal-Conductivity Gauges | |
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| Ionization Gauges | |
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| Types of Pumps | |
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| Mechanical Pumps (Low Vacuum).1) Rotary Vane.2) Scroll.3) Diaphram | |
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| High Vacuum.1) Turbomolecular Pumps.2) Diffusion Pumps.3) Sputter-Ion Pumps.4) Cryogenic Pumps | |
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| Mass Spectrometry/Mass Spectrometry | |
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| Introduction | |
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| Concept and Definitions | |
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| Nomenclature | |
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| Ion Dissociation | |
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| Metastable Ions | |
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| Instrumentation for MS/MS | |
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| MS/MS in Space | |
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| Tandem MS/MS.1) Triple-Quadrupole Mass Spectrometer.2) BEqQ Hybrid Instrument | |
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| Double-Focusing Instruments | |
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| MS/MS in Time | |
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| Specialized Techniques and Applications | |
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| In-Source CAD | |
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| CAD in Conjunction with Soft Ionization | |
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| Selected Reaction Monitoring | |
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| Precursor-Ion Scan | |
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| Neutral Loss (Common Loss) Scan | |
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| Ion/Molecule Reactions | |
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| Identification of Unknowns from CAD Data | |
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| Accurate Mass Measurements | |
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| Library Search Utilities | |
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| Other Databases | |
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| Substructure Information | |
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| Use of MS Interpreter | |
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| Inlet Systems | |
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| Introduction | |
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| Batch Inlets | |
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| Heated Reservoir Inlet | |
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| Direct Inlet Probe (DIP) | |
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| The Chromatoprobe | |
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| Direct Exposure Probe (Desorption Chemical Ionization [DCI]) | |
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| Pyrolysis | |
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| Continuous Inlets | |