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Cellular Biophysics Transport

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ISBN-10: 0262231832

ISBN-13: 9780262231831

Edition: 1996

Authors: Thomas Fischer Weiss

List price: $72.00
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Cellular Biophysics is a quantitatively oriented basic physiology text for senior undergraduate and graduate students in bioengineering, biophysics, physiology, and neuroscience programs. It will also serve as a major reference work for biophysicists. Developed from the author's notes for a course that he has taught at MIT for many years, these books provide a clear and logical explanation of the foundations of cell biophysics, teaching transport and the electrical properties of cells from a combined biological, physical, and engineering viewpoint. Each volume contains introductory chapters that motivate the material and present it in a broad historical context. Important experimental results and methods are described. Theories are derived almost always from first principles so that students develop an understanding of not only the predictions of the theory but also its limitations. Theoretical results are compared carefully with experimental findings and new results appear throughout. There are many time-tested exercises and problems as well as extensive lists of references. The volume on transport is unique in that no other text on this important topic develops it clearly and systematically at the student level. It explains all the principal mechanisms by which matter is transported across cellular membranes and describes the homeostatic mechanisms that allow cells to maintain their concentrations of solutes, their volume, and the potential across the membrane. Chapters are organized by individual transport mechanisms -- diffusion, osmosis, coupled solute and solvent transport, carrier-mediated transport, and ion transport (both passive and active). A final chapter discusses the interplay of all these mechanisms in cellular homeostasis.
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Book details

List price: $72.00
Copyright year: 1996
Publisher: MIT Press
Publication date: 3/6/1996
Binding: Hardcover
Pages: 730
Size: 8.50" wide x 9.50" long x 1.75" tall
Weight: 3.784
Language: English

Units, Physical Constants, and Symbols
Introduction to Membranes
Historical Perspective
Survey of Cell Structure
Cell Membrane Structure
Introduction to Transport
Cell Requirements
Transport in the Body Illustrated Using a Potato
Cellular Transport Functions
Survey of Transport Mechanisms
Methods for Studying Membrane Transport
Macroscopic Description
Microscopic Model
The Diffusion Coefficient
Equivalent Diffusion "Force"
Diffusion Processes
Membrane Diffusion
Two-Compartment Diffusion
Measurements of Diffusion Through Cellular Membranes
Solvent Transport
Hydraulic Pressure
Osmotic Pressure
Osmotic and Hydraulic Flow in Porous Media
Steady-State Solvent Transport Through Thin Membranes
The Physical Basis of Osmotic Pressure and Osmosis
Primary Responses of Cells to Changes in Osmotic Pressure
Molecular Mechanisms of Water Transport Through Cellular Membranes
Concurrent Solute and Solvent Transport
Concurrent, Uncoupled Transport of Solute and Solvent
Inadequacies of Uncoupled Flow Equations
Diffusion and Convection Through a Porous Membrane: Indistinguishable Solute
The Kedem-Katchalsky Equations for Linear, Coupled Flow Through a Membrane
Coupled Solute and Solvent Transport for a Cell
Carrier-Mediated Transport
Chemical Reactions: A Macroscopic Description
Discrete Diffusion Through Membranes
Carrier Models
Hexose Transport in Cells
Regulation of Glucose
Molecular Biology of Glucose Transporters
Ion Transport and Resting Potential
Continuum Electrodiffusion
The State of Intracellular Ions
Macroscopic Model of Passive Ion Transport
Resting Potential of Uniform Isolated Cells
Inadequacy of Passive Ion Transport Models
Active Ion Transport
Comparison of Active and Passive Transport
Cellular Homeostasis
Volume Regulation
General Equations for Homeostasis
Homeostasis for Simple Cell Models
Inventory of Homeostatic Mechanisms
Transport Mechanisms in Selected Cell Types